Egorov A.M.
Ulyashova M.M.
Rubtsova M.Y.
Published: Jan. 1, 2018
The resistance of microorganisms to antibiotics has been developing for more than 2 billion years and is widely distributed among various representatives of the microbiological world. Bacterial enzymes play a key role in the emergence of resistance. Classification of these enzymes is based on their participation in various biochemical mechanisms: modification of the enzymes that act as antibiotic targets, enzymatic modification of intracellular targets, enzymatic transformation of antibiotics, and the implementation of cellular metabolism reactions. The main mechanisms of resistance development are associated with the evolution of superfamilies of bacterial enzymes due to the variability of the genes encoding them. …
Zhuravlyova Larysa Vоlоdуmіrіvna
Lopina Nataliya Andreevna
Kuznetsov Igor Vоlоdуmirovich
Lopin Dmytro Oleksandrovich
Kramarenko Irina Anatolievna
Sumanova Irina Anatolievna
Published: Jan. 1, 2015
The article describes the etiologic role of various factors such as chronic rheumatic heart disease, bacterial endocarditis, aortic valve stenosis, hypertension, coronary heart disease, including acute myocardial infarction, degenerative disease of the valves, connective tissue diseases, chest trauma, sys-temic lupus erythematosus, con-genital heart disease which leading to the mitral valve chords rupture, gives the current classification of the nosology and also features of manifestation and clinical course. The authors also described a clinical case of mitral valve posterior leaflet chord rupture in the patient with hypertension, ischemic heart disease and chronic obstructive pulmonary disease, which reflects all the stages of …