Carbon, Journal Year: 2020, Volume and Issue: 161, P. 784 - 793
Published: Feb. 4, 2020
Language: Английский
Advanced Materials, Journal Year: 2022, Volume and Issue: 35(4)
Published: July 11, 2022
As a new class of materials, implantable flexible electrical conductors have recently been developed and applied to bioelectronics. An ideal conductor requires high conductivity, tissue-like mechanical properties, low toxicity, reliable adhesion biological tissues, the ability maintain its shape in wet physiological environments. Despite significant advances, that satisfy all these requirements are insufficient. Herein, facile method for manufacturing conductive hydrogels through simultaneous exfoliation graphite polymerization zwitterionic monomers triggered by microwave irradiation is introduced. The properties obtained hydrogel similar those living tissue, which as bionic adhesive minimizing contact damage due mismatches between hard electronics soft tissues. Furthermore, it exhibits excellent performance, non-swelling, conformability water. Excellent biocompatibility confirmed cytotoxicity test using C2C12 cells, on rat their histological analysis. then implanted into sciatic nerve neuromodulation demonstrated low-current stimulation. This demonstrates extraneuronal electrode, possesses improve tissue-electronics interfaces, promising next-generation bioelectronics applications.
Language: Английский
Citations
113
Small, Journal Year: 2023, Volume and Issue: 20(5)
Published: Sept. 26, 2023
Abstract Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from worldwide. The prevalence pathogens has led to a significant increase in medical costs poses great threat normal life people. This is an important issue field biomedicine, emergence new antimicrobial materials hydrogels holds promise for solving this problem. Hydrogel material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, controlled release drugs as well structural diversity. Bacteria‐disturbing have applications direction surgical treatment, wound dressing, device coating, tissue engineering. paper reviews classification hydrogels, current status research, potential one application analyzes research biomedical five aspects: metal‐loaded drug‐loaded carbon‐material‐loaded fixed activity biological provides outlook high activity, biodegradability, injectability, clinical applicability future development prospects field.
Language: Английский
Citations
52
Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 588 - 588
Published: July 21, 2023
Hydrogel-based bone tissue engineering is a potential strategy for treating abnormalities and fractures. Hyaluronic acid (HA) natural polymer that widely distributed in the human body plays significant role numerous physiological processes such as cell migration, hydration, wound healing. Hydrogels based on HA its derivatives have gained popularity treatments bone-related diseases. HA-based hydrogels been extensively studied their ability to mimic extracellular matrix of provide suitable microenvironment support regeneration. The physical chemical properties can be modified improve mechanical strength, biocompatibility, osteogenic potential. Moreover, combined with other biomaterials presence or absence bioactive agents investigated means improving bioactivity hydrogel scaffold. Therefore, shown great promise due activity, tissue. Overall, this review provides comprehensive overview current state art engineering, highlighting key advances, challenges, future directions rapidly evolving field.
Language: Английский
Citations
50
Journal of Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 999, P. 122819 - 122819
Published: July 20, 2023
Language: Английский
Citations
42
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)
Published: Jan. 17, 2024
Abstract Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer chronic diseases promote growth nanomedicine. However, there are very few analytical descriptive studies regarding trajectory nanomedicine, key research powers, present landscape, focal investigative points, future outlooks. Herein, articles reviews published Science Citation Index Expanded Web Core Collection from first January 2000 to 18th July 2023 analyzed. a bibliometric visualization publication trends, countries/regions, institutions, journals, categories, themes, references, keywords is produced elaborated. Nanomedicine‐related academic output increasing since COVID‐19 pandemic, solidifying uneven global distribution performance. While China leads terms quantity has numerous highly productive USA advantages impact, commercialization, industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, which drug delivery nanoparticles remain points. Current focuses on integrating nanomedicine cell ferroptosis induction immunotherapy. The keyword “burst testing” identifies promising directions, including immunogenic death, chemodynamic therapy, tumor microenvironment, immunotherapy, extracellular vesicles. prospects, major challenges, barriers addressing these directions discussed.
Language: Английский
Citations
39
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)
Published: Jan. 9, 2024
Abstract Electronic skin (E‐skin) that can mimic the flexibility and stretchability of human with sensing capabilities, holds transformative potential in robotics, wearable technology, healthcare. However, developing E‐skin poses significant challenges such as creating durable materials skin‐like flexibility, integrating biosensing abilities, using advanced fabrication techniques for or implantable applications. To overcome these hurdles, a 3D‐printed electronic utilizing novel class nanoengineered hydrogels tunable thermal capabilities is fabricated. This methodology takes advantage shear–thinning behavior hydrogel precursors, allowing to construct intricate 2D 3D structures. The elasticity triple crosslinking robust fungal exopolysaccharide, pullulan simulated, while defect‐rich molybdenum disulfide (MoS 2 ) nanoassemblies ensure high electrical conductivity. addition polydopamine nanoparticles enhances adhesion wet tissue. exhibits outstanding stretchability, adhesion, moldability, A distinctive feature this technology precise detection dynamic changes strain, pressure, temperature. As motion tracker, phonatory‐recognition platform, flexible touchpad, thermometer, represents breakthrough skins future robotics human‐machine interfaces.
Language: Английский
Citations
38
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 300 - 300
Published: Feb. 21, 2024
Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to prolonged effect. Nanomaterials have emerged promising candidates in field wound due their unique properties versatile applications. New insights into interactions between nanomaterials microenvironments shed light on mechanisms underlying therapeutic effects. However, significantly minimal amount research has been carried out see these promote process. In this review, we provided an outline various types that studied for wounds infection prevention. Overall, utilization holds great promise continues evolve, providing new opportunities development effective efficient care therapies.
Language: Английский
Citations
25
Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 534 - 548
Published: Feb. 22, 2024
Rehabilitation and regenerative medicine are two promising approaches for spinal cord injury (SCI) recovery, but their combination has been limited. Conductive biomaterials could bridge scaffolds with electrical stimulation by inducing axon regeneration supporting physiological signal transmission. Here, we developed aligned conductive hydrogel fibers incorporating carbon nanotubes (CNTs) into methacrylate acylated gelatin (GelMA) via rotating liquid bath electrospinning. The electrospun CNT/GelMA mimicked the micro-scale structure, conductivity, soft mechanical properties of neural axons. For
Language: Английский
Citations
25
ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(18), P. 7105 - 7114
Published: April 19, 2024
Conductive hydrogel is a promising material for flexible sensors due to its good electrical conductivity, adhesion, and high sensitivity. However, the challenge of integrating conductive fillers like liquid metals lies in their poor interface compatibility, which adversely affects mechanical strength lifespan. Addressing achieving both this study harnessed 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO)-oxidized lignin form stable between metal (LM) system. Furthermore, innovation (lignin-LM) facilitates free radical polymerization acrylic acid (PAA) at room temperature, resulting hydrogels. These hydrogels demonstrated excellent self-healing, adhesive, tensile, antibacterial properties, alongside strain sensing accuracy output sensor applications. In conclusion, PAA-Lignin-LM holds promise wearable, electronic products, introducing novel approach high-value utilization lignin.
Language: Английский
Citations
18
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(5), P. 1079 - 1114
Published: Jan. 1, 2024
Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,
Language: Английский
Citations
16