Steps Toward Recapitulating Endothelium: A Perspective on the Next Generation of Hemocompatible Coatings DOI Creative Commons
Lena Witzdam, Tom White, César Rodriguez‐Emmenegger

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Endothelium, the lining in this blood vessel, orchestrates three main critical functions such as protecting components, modulating of hemostasis by secreting various inhibitors, and directing clot digestion (fibrinolysis) activating tissue plasminogen activator. No other surface can perform these tasks; thus, contact blood‐contacting medical devices inevitably leads to activation coagulation, often causing device failure, thromboembolic complications. This perspective, first, discusses biological mechanisms coagulation highlights efforts advanced coatings recapitulate one characteristic endothelium, hereafter single endothelium noting necessity synergistic integration its functions. Subsequently, it is emphasized that overcome challenges compatibility an endothelium‐mimicking system needed, proposing a synergy bottom‐up synthetic biology, particularly cells, with passive‐ bioactive coatings. Such holds promise for developing biomaterials capable recapitulating endothelial functions, thereby enhancing hemocompatibility performance devices.

Language: Английский

Recent advances of multifunctional zwitterionic polymers for biomedical application DOI
Wenfeng Lv, Yanhui Wang, Huayu Fu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 19 - 45

Published: May 8, 2024

Language: Английский

Citations

19
Smart Lubricant Coating with Urease‐Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation DOI Open Access
Kaijun Li, Haibin Tang, Jinyu Peng

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(2)

Published: Sept. 22, 2023

Abstract Hydrophilic lubricant coatings with antifouling properties are commercially applied to urological devices, such as ureteral stents (USs), inhibit biofilm formation and reduce the likelihood of infectious encrustation. However, their long‐term effectiveness is limited due lack active precise antibacterial activity. Herein, this work reports a hydrophilic (defined SA‐PU/PVP) coating smart urease‐responsive antibiotic release functionality, achieved by incorporating sulfanilamide‐conjugated polyurethane (SA‐PU) polymers into commercial agent containing polyvinylpyrrolidone (PVP). During initial implantation period, PVP chains rapidly absorb urine on interface, forming lubricating layer desired activities that attachment host proteins, bacteria, urate crystals over 90%. As time progresses bacteria proliferates produces urease, urease enzymatically degrades urea linkages in SA‐PU/PVP coating, actively releasing SA antibiotics demand prevent Benefiting from synergistic activities, SA‐PU/PVP‐coated US exhibits superior performance preventing encrustation porcine model 7‐week surpassing US. This strategy offers practical solution for inhibiting device‐associated complications.

Language: Английский

Citations

25
Generalized Multifunctional Coating Strategies Based on Polyphenol-Amine-Inspired Chemistry and Layer-by-Layer Deposition for Blood Contact Catheters DOI

Jiahao Du,

Xiaoting Zhang, Wenlong Li

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(5), P. 3057 - 3068

Published: April 19, 2024

Blood-contacting catheters play a pivotal role in contemporary medical treatments, particularly the management of cardiovascular diseases. However, these exhibit inappropriate wettability and lack antimicrobial characteristics, which often lead to catheter-related infections thrombosis. Therefore, there is an urgent need for blood contact with anticoagulant properties. In this study, we employed tannic acid (TA) 3-aminopropyltriethoxysilane (APTES) create stable hydrophilic coating under mild conditions. Heparin (Hep) poly(lysine) (PL) were then modified on TA-APTES surface using layer-by-layer (LBL) technique superhydrophilic TA/APTES/(LBL)4 silicone rubber (SR) catheters. Leveraging nature coating, it can be effectively applied blood-contacting impart antibacterial, antiprotein adsorption, Due Hep's attributes, activated partial thromboplastin time thrombin tests conducted SR/TA-APTES/(LBL)4 revealed remarkable extensions 276 103%, respectively, when compared uncoated commercial SR Furthermore, synergistic interaction between PL TA serves enhance resistance against bacterial adherence, reducing by up 99.9% Remarkably, catheter exhibits good biocompatibility human umbilical vein endothelial cells culture, positioning as promising solution address current challenges associated blood-contact

Language: Английский

Citations

10
Sprayable Zwitterionic Antibacterial Hydrogel With High Mechanical Resilience and Robust Adhesion for Joint Wound Treatment DOI
Qinsheng Hu,

Yangrui Du,

Yangjing Bai

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(8)

Published: Jan. 19, 2024

Wound healing in movable parts, including the joints and neck, remains a critical challenge due to frequent motions poor flexibility of dressings, which may lead mismatching mechanical properties fitting between dressings wounds; thus, increasing risk bacterial infection. This study proposes sprayable zwitterionic antibacterial hydrogel with outstanding desirable adhesion. precursor is fabricated by combining sulfobetaine methacrylate (SBMA) poly(sulfobetaine methacrylate-co-dopamine methacrylamide)-modified silver nanoparticles (PSBDA@AgNPs) through robust electrostatic interactions. About 150 s exposure UV light, SBMA monomer polymerizes form PSB chains entangled PSBDA@AgNPs, transformed into stable adhesion PSB-PSB@Ag at wound site. The resulting has adhesive strength (15-38 kPa), large tensile strain (>400%), suitable shape adaptation, excellent resilience. Moreover, displays pH-responsive behavior; acidic microenvironment infected sites prompts rapidly release AgNPs kill bacteria. Further, effect demonstrated on rat neck skin wound, showing improved closing rate reduced inflammation enhanced angiogenesis. Overall, significant potential promote joint healing.

Language: Английский

Citations

8
Recent advances in zwitterionic polymers-based non-fouling coating strategies for biomedical applications DOI

Jiayao Wen,

Susu Huang,

Qiaoying Hu

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102232 - 102232

Published: July 31, 2024

Language: Английский

Citations

7
Metallic‐Polyphenolic Nanoparticles Reinforced Cationic Guar Gum Hydrogel for Effectively Treating Burn Wound DOI Open Access

Yangjing Bai,

Shiying Lang,

Yangrui Du

et al.

Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 24(3)

Published: Oct. 13, 2023

The development of injectable hydrogel dressings which are long-term moisturizing, easy-to-apply, and effectively inhibiting infection inflammatory is essential to promote burn wound repairing. Herein, an with antibacterial, anti-inflammation abilities via multiple reversible interactions between cation guar gum (CG) metallic-polyphenolic nanoparticles (PA-Zn

Language: Английский

Citations

13
Piezoelectrically-activated antibacterial catheter for prevention of urinary tract infections in an on-demand manner DOI Creative Commons
Xiaofeng Duan,

Yongde Xu,

Zhifa Zhang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101089 - 101089

Published: May 11, 2024

Catheter-associated urinary tract infection (CAUTI) is a common clinical problem, especially during long-term catheterization, causing additional pain to patients. The development of novel antimicrobial coatings needed prolong the service life catheters and reduce incidence CAUTIs. Herein, we designed an catheter coated with piezoelectric zinc oxide nanoparticles (ZnO NPs)-incorporated polyvinylidene difluoride-hexafluoropropylene (ZnO-PVDF-HFP) membrane. ZnO-PVDF-HFP could be stably onto silicone simply by one-step solution film-forming method, very convenient for industrial production. In vitro, it was demonstrated that coating significantly inhibit bacterial growth formation biofilm under ultrasound-mediated mechanical stimulation even after 4 weeks. Importantly, on off activity as well strenth antibacterial property controlled in adaptive manner via ultrasound. rabbit model, ZnO-PVDF-HFP-coated reduced CAUTIs compared clinically-commonly used assistance ultrasonication, no side effect detected. Collectively, study provided prevent occurance CAUTIs, whose on-demand manner, situation promising application.

Language: Английский

Citations

5
A robust mixed-charge zwitterionic polyurethane coating integrated with antibacterial and anticoagulant functions for interventional blood-contacting devices DOI

Jinyu Peng,

Kaijun Li,

Yangrui Du

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(33), P. 8020 - 8032

Published: Jan. 1, 2023

Antifouling coatings based on zwitterionic polymers have been widely applied for surface modification of interventional blood-contacting devices to combat thrombosis and infection. However, the weak adhesion stability coating device is still key challenge. In this work, biocompatible mixed-charge polyurethane (MPU) polymers, that bear equal amounts cationic quaternary amine groups anionic carboxyl groups, were developed further uniformly dip-coated onto a thermoplastic (TPU) substrate with commercial aliphatic isocyanate cross-linker (AIC). During curing process, AIC not only crosslinks MPU chains into polymer network but also reacts hydroxyl TPU interlink substrate, resulting in cross-linking reinforced (CMPU) excellent mechanical robustness strength. Taking advantage feature, final CMPU exhibits both antifouling antibacterial activities against protein adsorption bacterial growth, respectively, which beneficial effectively inhibiting occurrence vivo Moreover, anticoagulation studies show CMPU-coated catheters can prevent formation blood clots ex rabbit circuits without anticoagulants. Hence, designed has immense potential address infection devices.

Language: Английский

Citations

11
Antifouling Zwitterionic Polymer Coatings for Blood-Bearing Medical Devices DOI Creative Commons
Kagya A. Amoako, Rei Ukita, Keith E. Cook

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Blood-bearing medical devices are essential for the delivery of critical care medicine and often required to function weeks months. However, thrombus formation on their surfaces can lead reduced device failure expose patients systemic thrombosis risks. While clinical anticoagulants reduce related thrombosis, they also increase patient bleeding risk. The root cause inflammation is protein adsorption biomaterial these devices. Protein activates coagulation cascade complement, this, in turn, platelets white blood cells. Surface modifications with zwitterionic polymers particularly effective at reducing as well conformational changes proteins due hydrophilicity. Multiple coating strategies have been developed using carboxybetaine (CB), sulfobetaine (SB), 2-methacryloyloxyethyl phosphorylcholine (MPC) applied metals hydrophobic that make up bulk blood-bearing These coatings highly successful creating large reductions platelet adhesion during studies order hours flat a few days full Future work needs focus ability limit inflammation, hemodialysis, providing anticoagulation weeks, artificial lungs.

Language: Английский

Citations

0
Pegylated and peptide-functionalized supramolecular metal-phenolic network coatings for enhanced performance of cardiovascular grafts DOI
Hewan Dawit, Zahid Hussain, Shah Mehmood

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160296 - 160296

Published: Feb. 1, 2025

Language: Английский

Citations

0