Enzyme-loaded manganese−porphyrin metal−organic nanoframeworks for oxygen-evolving photodynamic therapy of hypoxic cells DOI Creative Commons
Yang Qiao,

Xiaowan Tang,

Xu Qiuju

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33902 - e33902

Published: July 1, 2024

Photodynamic therapy (PDT) is attracting great attention for cancer treatments, while its therapeutic efficacy limited by unsatisfactory photosensitizers and hypoxic tumor microenvironment (TME). To address these problems, we have developed catalase-loaded manganese-porphyrin frameworks (CAT@MnPFs) catalytically-assisted PDT of cells. CAT@MnPFs were constructed the assembly Mn2+ ions PpIX into MnPFs subsequent loading catalase. Under 650 nm light irradiation, porphyrin (Protoporphyrin IX) within structure can convert oxygen (O2) singlet (1O2), showing photodynamic effect. Importantly, loaded catalase decompose hydrogen peroxide (H2O2) O2 with a huge elevation level (13.22 mg L−1) in 600 s, thus promoting 1O2 generation via PDT. As result, combined effectively ablate cells due to catalase-assisted oxygen-evolving PDT, high efficacy. Meanwhile, after incubation CAT@MnPFs, unobvious damage be found normal red blood Thus, obtained integrate advantage which provide some insight treating

Language: Английский

Defect engineering synergistically boosts the catalytic activity of Fe-MoOv for highly efficient breast mesh antitumor therapy DOI
Wenjing Yang,

Chuanyin Zhou,

Chongxian He

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 260 - 271

Published: Aug. 25, 2024

Language: Английский

Citations

28
Type‐Transformational BioHJzyme Enabled by Composition Modulation‐Mediated Energy Band Engineering for Diabetic Infectious Wound Healing DOI Open Access
Miaomiao He,

Zuyao Wang,

Dan Sun

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract The dilemma of diabetic infectious wound healing lies in inhibiting the pathogenic colonization and regulating hyperglycemia. pivotal anti‐pathogenic efficiency is focused on confined gradually weaken reactive oxygen species (ROS) yield peculiar micromilieu owing to materials transformation/dissolution. There, type‐transformational bio‐heterojunction enzyme (BioHJzyme) with operando composition‐modulation proposed, which consisted by glucose oxidase (GOx) decorated type‐I FeSe 2 /Cu O heterojunction. It exhibits robust catalytic produce ROS. Followed, heterojunction can be transformed into dual Z‐scheme a composition /CuSe/Cu primed acid meliorative energy band. conducive NIR‐induced capabilities improve ROS yield. GOx consume H as an amplifier. combined followed enhanced powerfully remove colonization. On top that, sample downgrade Forkhead box (FoxO) signaling pathway regulate cell cycle, facilitate proliferation, further promote repairment. This work provides effective feasible antibacterial strategy way thinking for healing.

Language: Английский

Citations

2
Photo-Controlled extracellular electron transfer in Non-Extracellular respiratory bacteria by constructing a nanoscale interface material for energy transformation DOI
Yunxia Wang, Fengli Wei, Guoying Jiang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159553 - 159553

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multifunctional nanozymes for sonodynamic-enhanced immune checkpoint blockade therapy by inactivating PI3K/AKT signal pathway DOI
Mei Wen,

Pu Qiu,

Jialan Meng

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123125 - 123125

Published: Jan. 1, 2025

Language: Английский

Citations

0
The construction of p-n heterojunction in nanozyme for improved peroxidase-like activity and “point-of-use” water disinfection DOI

Jun‐Jun Lu,

K. Yao, Xinxin Xu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161757 - 161757

Published: March 1, 2025

Language: Английский

Citations

0
Immunotherapy strategy for treating inflammatory bowel disease based on a nanozyme/total glucosides of paeony hybrid materials DOI Creative Commons
Zetian Wang,

Ningning Hu,

Longqiu Yang

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory condition that has long plagued patients. Herein, an innovative oral treatment strategy for IBD proposed, which utilizes calcium alginate hydrogel as carrier to deliver Co3O4 nanocages loaded with total glucosides of paeony (TGP) into the body. This design ingeniously exploits protective properties outer layer ensure enzyme not prematurely degraded when passing through acidic gastric juice. However, upon reaching inflamed intestinal site, overexpressed H2O2 there mixes specific solution, causing degrade and release Co3O4@TGP. These negatively charged nanozymes can precisely recognize accumulate in colonic tissue, achieving targeted therapy their unique charge characteristics. More importantly, itself possesses excellent catalytic activity, effectively consuming excess at site inflammation degrading 10 nm small particles process, while simultaneously releasing TGP. Together, they exert dual effects scavenging reactive oxygen species (ROS) anti-inflammation. Its therapeutic mechanism involves fine regulation expression key proteins such TLR7, MYD88, GAPDH, well effective inhibition NF-κB signaling pathway. series actions only reduces various pro-inflammatory cytokines (such TNF-α, IL-18, IL-1β, IL-6, HMGB1) but also promotes production anti-inflammatory cytokine IL-10, thereby maintaining integrity barrier. research achievement opens up novel path colitis.

Language: Английский

Citations

0
A catalase-like nanozyme of high activity and stability in acidic solutions for enzyme immobilization and chemoenzymatic cascade conversion of glucose to gluconic acid DOI
Ziyi Yang, Xiaoyan Dong, Zhenfu Wang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 482, P. 144140 - 144140

Published: April 2, 2025

Language: Английский

Citations

0
Enzyme-loaded manganese−porphyrin metal−organic nanoframeworks for oxygen-evolving photodynamic therapy of hypoxic cells DOI Creative Commons
Yang Qiao,

Xiaowan Tang,

Xu Qiuju

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33902 - e33902

Published: July 1, 2024

Photodynamic therapy (PDT) is attracting great attention for cancer treatments, while its therapeutic efficacy limited by unsatisfactory photosensitizers and hypoxic tumor microenvironment (TME). To address these problems, we have developed catalase-loaded manganese-porphyrin frameworks (CAT@MnPFs) catalytically-assisted PDT of cells. CAT@MnPFs were constructed the assembly Mn2+ ions PpIX into MnPFs subsequent loading catalase. Under 650 nm light irradiation, porphyrin (Protoporphyrin IX) within structure can convert oxygen (O2) singlet (1O2), showing photodynamic effect. Importantly, loaded catalase decompose hydrogen peroxide (H2O2) O2 with a huge elevation level (13.22 mg L−1) in 600 s, thus promoting 1O2 generation via PDT. As result, combined effectively ablate cells due to catalase-assisted oxygen-evolving PDT, high efficacy. Meanwhile, after incubation CAT@MnPFs, unobvious damage be found normal red blood Thus, obtained integrate advantage which provide some insight treating

Language: Английский

Citations

1