Metal–Organic Frameworks for Biomedical Applications

Small, Journal Year: 2020, Volume and Issue: 16(10)

Published: Feb. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Frontiers in Molecular Biosciences, Journal Year: 2020, Volume and Issue: 7

Published: Oct. 30, 2020

In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage original concepts and ideas. There is no doubt that nanoformulations extremely valuable tools for drug delivery applications; current challenge how to optimize them ensure they safe, effective scalable, so can be manufactured at an industrial level advance clinical use. this context, lipid nanoparticles have gained ground, since generally regarded as non-toxic, biocompatible easy-to-produce formulations. Pharmaceutical applications nanocarriers burgeoning field transport diversity therapeutic agents, from biotechnological products small molecules. This review starts with brief overview characteristics solid discusses relevancy performing systematic preformulation studies. The main applications, well advantages type nanovehicles offers in certain scenarios discussed. Next, pharmacokinetic aspects described, such routes administration, absorption after oral distribution organism (including brain penetration) elimination processes. Safety toxicity issues also addressed. Our work presents point view, addressing biopharmaceutical these by means descriptive statistics state-of-the-art research. All presented results, trends, graphs discussions based (and reproducible) bibliographic search considered only papers subject, covering 7 years range (2013-today), period accounts more than 60% total number publications topic databases engines. Focus was placed on fields application, processes efforts translation into practice lipid-based nanoparticles. For this, currently active trials were reviewed, discussion what achievements or milestones still reached, way understanding reasons scarce undergoing trials.

Language: Английский

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Safe Nanoparticles: Are We There Yet?

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 22(1), P. 385 - 385

Published: Dec. 31, 2020

The field of nanotechnology has grown over the last two decades and made transition from benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles, have emerged as promising tools with broad applications in drug delivery, diagnostics, cosmetics several other biological non-biological areas. These advances lead questions about nanoparticle safety. Despite considerable efforts understand toxicity safety these many are not yet fully answered. Nevertheless, identified approaches minimize prevent promote safer nanotechnology. This review summarizes our current knowledge on their toxic effects, interactions mammalian cells finally minimizing toxicity.

Language: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Recent Developments of Carbon Dots in Biosensing: A Review

ACS Sensors, Journal Year: 2020, Volume and Issue: 5(9), P. 2724 - 2741

Published: Aug. 19, 2020

Early diagnosis of diseases is great importance because it increases the chance a cure and significantly reduces treatment costs. Thus, development rapid, sensitive, reliable biosensing techniques essential for benefits human life health. As such, various nanomaterials have been explored to improve performance biosensors, among which, carbon dots (CDs) received enormous attention due their excellent performance. In this Review, recent advancements CD-based biosensors carefully summarized. First, are classified according sensing strategies, role CDs in these sensors elaborated detail. Next, several typical (including CD-only, enzymatic, antigen–antibody, nucleic acid biosensors) applications fully discussed. Last, advantages, challenges, perspectives on future trends highlighted.

Language: Английский

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Solvent-Assisted Self-Assembly of a Metal–Organic Framework Based Biocatalyst for Cascade Reaction Driven Photodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(14), P. 6822 - 6832

Published: March 20, 2020

Biocatalytic reactions in living cells involve complex transformations the spatially confined microenvironments. Inspired by biological transformation processes, we demonstrate effective biocatalytic cascade driven photodynamic therapy tumor-bearing mice integration of an artificial enzyme (ultrasmall Au nanoparticles) with upconversion nanoparticles ([email protected]:Er0.08@NaYF4)zirconium/iron porphyrin metal-organic framework core-shell (UMOF NPs) which act as biocatalysts and nanoreactors. The construction UMOF NPs are realized using a unique "solvent-assisted self-assembly" method. ultrasmall AuNPs on UMOFs matrix leads to glucose depletion, providing Au-mediated cancer via oxidase like catalytic activity. Meanwhile, acts near-infrared (NIR) light photon-activated singlet oxygen generator through continuous supply hydrogen peroxide decomposition upon irradiation. Such kinds offer exciting opportunities for biomedical, catalytical ,and energy applications.

Language: Английский

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Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4432 - 4483

Published: Jan. 1, 2021

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties widespread industrial use. In recent decades, accessibility, versatile reactivity, relative biocompatibility catalysed phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which been a major benefactor this emergence, as largely demonstrated by polydopamine polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms synthetic strategies PEN state-of-the-art provide timely comprehensive summary. review, we will focus on principles involved summarize use toolkit particle engineering bottom-up synthesis nanohybrid materials. Specifically, discuss attractive forces between phenolics complementary structural motifs confined systems synthesize high-quality products with controllable size, shape, composition, well surface chemistry function. Additionally, phenolic's numerous biosensing, bioimaging, disease treatment be highlighted. This review aims guidelines new scientists field serve an up-to-date compilation what has achieved area, while offering expert perspectives PEN's translational research.

Language: Английский

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Photonic Carbon Dots as an Emerging Nanoagent for Biomedical and Healthcare Applications

ACS Nano, Journal Year: 2020, Volume and Issue: 14(6), P. 6470 - 6497

Published: May 22, 2020

As a class of carbon-based nanomaterials, carbon dots (CDs) have attracted enormous attention because their tunable optical and physicochemical properties, such as absorptivity photoluminescence from ultraviolet to near-infrared, high photostability, biocompatibility, aqueous dispersity. These characteristics make CDs promising alternative photonic nanoagent conventional fluorophores in disease diagnosis, treatment, healthcare managements. This review describes the fundamental photophysical properties highlights recent applications bioimaging, photomedicine (e.g., photodynamic/photothermal therapies), biosensors, devices. We discuss current challenges future prospects give an insight into developing vibrant fields CD-based biomedicine healthcare.

Language: Английский

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Stability of ZIF-8 nanopowders in bacterial culture media and its implication for antibacterial properties

Chemical Engineering Journal, Journal Year: 2020, Volume and Issue: 413, P. 127511 - 127511

Published: Oct. 27, 2020

Language: Английский

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