Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Nov. 24, 2023

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu

Language: Английский

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Oct. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Language: Английский

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Drug in Drug: Quorum Sensing Inhibitor in Star-Shaped Antibacterial Polypeptides for Inhibiting and Eradicating Corneal Bacterial Biofilms

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Biofilm-related bacterial keratitis is a severe ocular infection that can result in drastic vision impairment and even blindness. However, the therapeutic efficiency of clinical antibiotic eyedrops often compromised because bacteria biofilms resist bactericide

Language: Английский

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A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215600 - 215600

Published: Dec. 14, 2023

Language: Английский

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Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(25)

Published: Feb. 21, 2024

Abstract Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines based on peptide or derivatives self‐assembly that are constructed in vitro vivo. Benefiting from the inherent advantages of peptides, such as good biocompatibility, high bioactivity, and flexible tunability, reported PST have shown excellent application prospects combating many major diseases including cancer, cardiovascular disease, infectious autoimmune metabolic so on. Through thoughtful design, can be fabricated various forms, self‐assembled precursor molecules, functional nano‐assemblies, macroscopic large‐scale hydrogels. The involved peptides play different roles, serving drug carriers for effective delivery, acting scaffold materials cell culture, functioning bioactive sequences treating diseases. In this review, a comprehensive overview traditional strategies is provided build emphasize their therapeutic applications fighting pose threat human life health. Moreover, main challenges systems application, clinical translation also briefly discussed. It hoped review arouse much more attention paid promote its practical biomedical field.

Language: Английский

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Staphylococcus aureus and biofilms: transmission, threats, and promising strategies in animal husbandry

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 13, 2024

Abstract Staphylococcus aureus ( S. ) is a common pathogenic bacterium in animal husbandry that can cause diseases such as mastitis, skin infections, arthritis, and other ailments. The formation of biofilms threatens exacerbates infection by allowing the bacteria to adhere pathological areas livestock product surfaces, thus triggering health crises safety issues with products. To solve this problem, review, we provide brief overview harm caused its on byproducts (meat dairy products). We also describe ways which spreads animals threats it poses industry. processes molecular mechanisms involved biofilm are then explained. Finally, discuss strategies for removal eradication husbandry, including use antimicrobial peptides, plant extracts, nanoparticles, phages, antibodies. These reduce spread help maintain improve productivity ensure ecologically sustainable development

Language: Английский

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Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(7), P. 2507 - 2531

Published: Jan. 1, 2024

Neuropeptide substance P (SP) belongs to a family of bioactive peptides and regulates many human diseases. This study aims investigate the role underlying mechanisms SP in colitis. Here, activated SP-positive neurons increased expression were observed dextran sodium sulfate (DSS)-induced colitis lesions mice. Administration exogenous efficiently ameliorated clinical symptoms, impaired intestinal barrier function, inflammatory response. Mechanistically, protected mitochondria from damage caused by DSS or TNF-α exposure, preventing mitochondrial DNA (mtDNA) leakage into cytoplasm, thereby inhibiting cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway. can also directly prevent STING phosphorylation through neurokinin-1 receptor (NK1R), activation TBK1-IRF3 signaling Further studies revealed that alleviated TNF-α-induced ferroptosis process, which was associated with repressing cGAS-STING Notably, we identified NK1R inhibition reversed effects on inflammation via Collectively, unveil attenuates suppressing mtDNA-cGAS-STING acting pathway, contributing improving an NK1R-dependent manner. These findings provide novel mechanism regulating ulcerative (UC) disease.

Language: Английский

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Urchin-like Fe₃O₄@Bi₂S₃ Nanospheres Enable the Destruction of Biofilm and Efficiently Antibacterial Activities

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(3), P. 3215 - 3231

Published: Jan. 11, 2024

Biofilm-associated infections (BAIs) have been considered a major threat to public health, which induce persistent and serious complications. The poor penetration of antibacterial agents in biofilm significantly limits the efficiency combating BAIs. Magnetic urchin-like core–shell nanospheres Fe3O4@Bi2S3 were developed for physically destructing inducing bacterial eradication via reactive oxygen species (ROS) generation innate immunity regulation. magnetic with sharp edges exhibited propeller-like rotation destroy under rotating field (RMF). mild hyperthermia improved ROS enhanced eradication. Significantly, nanostructure generated could stimulate macrophage polarization toward M1 phenotype, eradicate bacteria metabolic inactivity state through phagocytosis, thereby promoting recovery implant infection inhibiting recurrence. Thus, design magnetic-driven sharp-shaped nanostructures provided enormous potential infections.

Language: Английский

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Elaborated Bio‐Heterojunction With Robust Sterilization Effect for Infected Tissue Regeneration via Activating Competent Cell‐Like Antibacterial Tactic

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(48)

Published: Oct. 13, 2024

Phototherapy, such as photothermal therapy (PTT) and photodynamic (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug-resistant significantly diminish efficiency heat conduction impede entrance reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by membrane feature competent herein MXene/CaO

Language: Английский

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Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating Lactobacillus rhamnosus GG

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With growing knowledge about gut–bone axis, therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. AlthoughLactobacillus rhamnosus GG (LGG) widely reported positively regulate metabolism by restoring dysbiotic microbiome, oral administration sensitivity gastric fluid low bioavailability. Other studies also demonstrated that bisphosphonates ameliorate directly metabolism, especially inhibiting osteoclast activity. However, side effects caused bisphosphonate treatment still represent a significant problem. In this study, we assembled alendronate, clinically used bisphosphonate, DSPE-phospholipid nanoencapsulation LGG (ADB), protect from acidic environment of stomach, while simultaneously reducing gastrointestinal alendronate. We further investigated potential these nanoencapsulated bacteria ADB repair osteoporotic deterioration, their ability in vivo, which strongly intrinsic environment. Compared same dosage alendronate alone, regulated was significantly revised ovariectomized mice models.

Language: Английский

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