Ultrasound‐Responsive Aligned Piezoelectric Nanofibers Derived Hydrogel Conduits for Peripheral Nerve Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: May 15, 2024

Nerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes limited by the lack of controllable drug delivery available physicochemical cues. Herein, novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)-triggered electrical stimulation (ES) release repairing injury proposed. The inner layer is barium titanate nanoparticles (BTNPs)-doped polyvinylidene fluoride-trifluoroethylene [BTNPs/P(VDF-TrFE)] electrospinning improved piezoelectricity orientation. outer side thermoresponsive poly(N-isopropylacrylamide) hybrid bioactive encapsulation. Such can not only induce neuronal-oriented extension promote neurite outgrowth US-triggered wireless ES, but also realize growth factor shrinkage under heating. Thus, NGC positively accelerate functional recovery axonal regeneration rat models long sciatic defects. It believed that proposed US-responsive will find important applications in clinic neural tissue engineering.

Language: Английский

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Nerve‐on‐a‐Chip Derived Biomimicking Microfibers for Peripheral Nerve Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(20)

Published: April 29, 2023

Fibrous scaffolds have shown their advantages in tissue engineering, such as peripheral nerve regeneration, while most of the existing fiber-shaped are with simple structures, and vitro performance for regeneration lacks systematic analysis. Here, novel nerve-on-a-chip derived biomimicking microfibers presented. The controllable core-shell structures functionalities generated through capillary microfluidic devices. By integrating these into a multitrack-architectured chip, coculturing them cells well gradient bioactive elements, capabilities systematically assessing performances fiber formation hollow at level is constructed. Based on rat sciatic injury model, rapid promotion ability demonstrated optimized function recovery vivo, which implies credibility evaluation regeneration. Thus, it convinced that organ-on-a-chip will undoubtedly open up new chapter evaluating biological vivo engineering.

Language: Английский

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Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(5)

Published: Jan. 21, 2024

Peripheral nerve injuries (PNI) represent a prevalent and severe category of damage resulting from traumatic incidents. Predominantly, the deficiency in regeneration can be ascribed to enduring inflammatory reactions, hence imposing substantial clinical implications for patients. Fisetin, flavonoid derived plants, is naturally present an array vegetables fruits, including strawberries, apples, onions, cucumbers. It exhibits immunomodulatory properties through reduction inflammation oxidative stress. In research, defect addressed first time utilizing scaffold primed controlled fisetin release. this regard, fisetin-loaded chitosan hydrogels are incorporated into lumen polycaprolactone (PCL) guide conduits (NGCs). The hydrogel maintained steady release appropriate dosage. study outcomes indicated that fisetin/chitosan/polycaprolactone (FIS/CS/PCL) NGCs amplified Schwann cell proliferation neural expression, curtailed stress, alleviated inflammation, improved functions, electrophysiological properties, morphology. This pioneering has potential contribute significantly field neuroengineering.

Language: Английский

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Innovations in spider silk‐inspired artificial gel fibers: Methods, properties, strengthening, functionality, and challenges

SusMat, Journal Year: 2024, Volume and Issue: 4(3)

Published: May 27, 2024

Abstract Spider silk, possessing exceptional combination properties, is classified as a bio‐gel fiber. Thereby, it serves valuable origin of inspiration for the advancement various artificial gel fiber materials with distinct functionalities. Gel fibers exhibit promising potential utilization in diverse fields, including smart textiles, muscle, tissue engineering, and strain sensing. However, there are still numerous challenges improving performance functionalizing applications spider silk‐inspired fibers. Thus, to gain penetrating insight into bioinspired fibers, this review provided comprehensive overview encompassing three key aspects: fundamental design concepts implementing strategies properties strengthening functionalities application prospects In particular, multiple toughening mechanisms were introduced at micro, nano, molecular‐level structures Additionally, existing summarized. This aims offer significant guidance development inspire further research field high‐performance

Language: Английский

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Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(3)

Published: Nov. 3, 2023

Hydrogels are considered as a promising medical patch for wound healing. Researches in this aspect focused on improving their compositions and permeability to enhance the effectiveness of Here, novel prolamins-assembled porous hydrogel microfibers with desired merits treating diabetes wounds presented. Such continuously generated by one-step microfluidic spinning technology acetic acid solution prolamins continuous phase deionized water dispersed phase. By adjusting prolamin concentration flow rates microfluidics, structure morphology well diameters can be tailored. Owing porosity, resultant employed flexible delivery systems healing actives, such bacitracin vascular endothelial growth factor (VEGF). It is demonstrated that good cell-affinity effective drug release efficiency, woven patches display superior vivo capability wounds. Thus, it believed proposed will show important values clinic treatments.

Language: Английский

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Hydrogel-based hollow microfibers for functional esophageal carcinoma remodeling

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102358 - 102358

Published: Jan. 1, 2025

Language: Английский

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Continuous fabrication of hollow photocatalytic CNT/TiO2/calcium alginate microfibers via needle-based microfluidic device for environmental remediation in NO removal

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115750 - 115750

Published: Feb. 1, 2025

Language: Английский

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Multifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101588 - 101588

Published: Feb. 19, 2025

Language: Английский

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Percutaneous electrical stimulation combined with conductive nerve guidance conduits for peripheral nerve regeneration

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162124 - 162124

Published: March 1, 2025

Language: Английский

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Micro/nanoengineered agricultural by-products for biomedical and environmental applications

Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118490 - 118490

Published: Feb. 14, 2024

Language: Английский

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