Bone-Adhesive Peptide Hydrogel Loaded with Cisplatin for Postoperative Treatment of Osteosarcoma DOI
Jianxing Zhou,

Taotao Huo,

Junxian Miu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

The inhibition of residual tumor recurrence while repairing bone defects poses a challenging issue for postoperative osteosarcoma treatment. Here, we develop self-assembling peptide hydrogel (GelA) the targeted delivery cisplatin (CDDP), aiming to integrate with defect repair. GelA exhibits exceptional biocompatibility, high loading capacity CDDP, and superior adhesion. After in situ injection defects, CDDP-loaded GelA-CDDP demonstrates strong affinity hydroxyapatite, thereby facilitating optimal adhesion prolonging retention time CDDP wound. Furthermore, can regulate distribution release behavior minimizing off-target effects optimizing therapeutic outcomes chemotherapy osteogenesis. Finally, orthotopic transplantation model mice, treatment significantly inhibits as well repair through synergistic osteogenesis promotion osteoclastic inhibition. We believe that this hydrogel-based therapy strategy holds great promise achieving simultaneous

Language: Английский

Role of degrading hydrogels in hepatocellular carcinoma drug delivery applications: A review DOI
Satheesh Selvaraj, Ankush Chauhan, Ritesh Verma

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105628 - 105628

Published: April 4, 2024

Language: Английский

Citations

7
Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy DOI Creative Commons
Youyou Li, Jing Liu, Ralph R. Weichselbaum

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions inhibitors efficiently simultaneously Herein, mitochondria-targeted nanoscale coordination polymer particle, Cu/TI, comprising Cu(II), triphenylphosphonium conjugate 5-carboxy-8-hydroxyquinoline (TI), for effective induction programmed cell death-1 (PD-L1) downregulation is reported. Upon systemic administration, Cu/TI accumulates tumor tissues induce immunogenic cancer death reduce PD-L1 expression. Consequently, promotes the intratumoral infiltration activation cytotoxic T lymphocytes greatly inhibit progression colorectal carcinoma triple-negative breast mouse models without causing obvious side effects.

Language: Английский

Citations

7
Multiple Immunomodulatory Strategies Based on Targeted Regulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Immune Homeostasis against Hepatocellular Carcinoma DOI

Shiji Fang,

Liyun Zheng,

Gaofeng Shu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(12), P. 8811 - 8826

Published: March 11, 2024

Immunotherapy is the most promising systemic therapy for hepatocellular carcinoma. However, outcome remains poor. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a role in altering cell-surface protein levels, potentially undermining efficacy of immunotherapy against tumors. This highlights its potential as target antitumor therapy. Herein, CaCO3-based nanoparticles coencapsulated with DOX, an immunogenic cell death (ICD) inducer, and evolocumab was developed to enhanced immunotherapy. The obtained DOX/evolocumab-loaded CaCO3 nanoparticle (named DECP) exhibits good capacity acid neutralization causes ICD cancer cells. In addition, DECP able evaluate level MHC-I, biomarker that correlates positively patients' overall survival. Upon intravenous injection, accumulates within tumor site, leading growth inhibition hepa1-6 bearing subcutaneous Specifically, treatment augmented ratios matured dendritic cells, tumor-infiltrating CD8+ T cells natural killing while concurrently depleting Foxp3+ regulatory Peritumoral delivery enhances immune response distant tumors effects when combined αPD-L1 bilateral model. study presents multiple immunomodulatory strategies carcinoma by targeting PCSK9 modulating homeostasis unfavorable TME.

Language: Английский

Citations

6
Ferritin‐Based Nanocomposite Hydrogel Promotes Tumor Penetration and Enhances Cancer Chemoimmunotherapy DOI Creative Commons
Rong Liu, Qian Liang, Jia‐Qi Luo

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(3)

Published: Nov. 29, 2023

Abstract Hydrogels are prevailing drug delivery depots to improve antitumor efficacy and reduce systemic toxicity. However, the application of conventional free drug‐loaded hydrogel is hindered by poor penetration in solid tumors. Here, an injectable ferritin‐based nanocomposite constructed facilitate tumor cancer chemoimmunotherapy. Specifically, doxorubicin‐loaded human ferritin (Dox@HFn) oxidized dextran (Dex‐CHO) used construct (Dox@HFn Gel) through formation pH‐sensitive Schiff‐base bonds. After peritumoral injection, Dox@HFn Gel retained locally for up three weeks, released intact gradually, which can not only active transcytosis but also induce immunogenic cell death (ICD) cells generate immune response. Combining with anti‐programmed death‐1 antibody (αPD‐1), induces remarkable regression orthotopic 4T1 breast tumors, further elicits a strong anti‐tumor response effectively suppress recurrence lung metastasis tumors after surgical resection. Besides, combination L anti‐CD47 (αCD47) inhibits postsurgical aggressive glioblastoma model significantly extends mice survival. This work sheds light on construction local hydrogels potentiate improved therapy.

Language: Английский

Citations

13
Glioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe2+ and boosting Fenton reaction DOI Creative Commons
Xue Li, Ying Cheng, Zhifu Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 5, 2024

Abstract Glioma is easy to develop resistance temozolomide (TMZ). TMZ-resistant glioma secretes interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), recruiting regulatory T cell (T reg ) inhibiting the activity of cells natural killer (NK cell), subsequently forming an immunosuppressive microenvironment. Oxaliplatin (OXA) greatly inhibits proliferation cells, but ability OXA cross blood–brain barrier (BBB) weak. Thus, therapeutic effect on not satisfactory. Transferrin receptor 1 (TfR1) highly expressed in brain capillary endothelial cells. In this study, was loaded into ferritin (Fn) prepare glioma-targeted oxaliplatin/ferritin clathrate OXA@Fn. OXA@Fn efficiently crossed BBB actively taken up by via TfR1. Then, increased intracellular H 2 O level induced apoptosis Meanwhile, Fn Fe 2+ addition, expression ferroportin significantly reduced, resulting be locked inside This enhanced Fenton reaction boosted ferroptosis Consequently, mediated anti-tumor immune response strongly induced, microenvironment reversed tissue. Ultimately, invasion inhibited shows great potential treatment prospect clinical transformation. Graphical

Language: Английский

Citations

5
Ferroptosis, pyroptosis and necroptosis in hepatocellular carcinoma immunotherapy: Mechanisms and immunologic landscape (Review) DOI Creative Commons
Ruijia Liu, Xudong Yu,

Shao-Shuai Yan

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(6)

Published: May 9, 2024

Hepatocellular carcinoma (HCC), one of the leading causes cancer‑related mortality worldwide, is challenging to identify in its early stages and prone metastasis, prognosis patients with this disease poor. Treatment options for HCC are limited, even radical treatments being associated a risk recurrence or transformation short term. Furthermore, multi‑tyrosine kinase inhibitors approved first‑line therapy have marked drawbacks, including drug resistance side effects. The rise breakthrough immune checkpoint (ICIs) provided novel direction immunotherapy but these drawback low response rates. Since avoiding apoptosis universal feature cancer, induction non‑apoptotic regulatory cell death (NARCD) strategy immunotherapy. At present, NARCD pathways, ferroptosis, pyroptosis necroptosis, potential forms immunogenic death, which synergistic effects antitumor immunity, transforming 'cold' tumors into 'hot' exerting Therefore, pathways may be targeted as treatment HCC. In present review, roles necroptosis immunity discussed, relevant targets signaling current status combined ICIs summarized. prospects targeting also considered.

Language: Английский

Citations

5
Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy DOI

Hailin Zhu,

Haowei Sun, Jingyuan Dai

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047

Published: Nov. 1, 2024

Language: Английский

Citations

5
Hydrogel Crosslinked with Nanoparticles for Prevention of Surgical Hemorrhage and Recurrence of Hepatocellular Carcinoma DOI Creative Commons

Jiaqi Zhu,

Han Wu, Xu Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(9)

Published: Dec. 25, 2023

Abstract Hepatocellular carcinoma (HCC) is acknowledged as an immunosuppressive neoplasm, whereby the inactive microenvironment facilitates immune tolerance and evasion of HCC. Post‐surgical resected liver cancer exhibits a proclivity for relapse, rendering prevention recurrence challenging it may transpire at any point subsequent to surgery. Among various anti‐recurrence interventions, primary clinical approach involving administration regimens atezolizumab bevacizumab (A+T) deemed most efficacious in reversing tumor microenvironment, albeit still lacking complete satisfaction. Therefore, objective utilize recently developed block copolymer protective carrier two specific monoclonal antibody drugs. Subsequently, modified hemostatic hydrogel will be synthesized application during hepatic The immunotherapy impact this significantly prolonged intensified due combined hemostasis properties controlled release constituents within nanocomposite hydrogel. Furthermore, these hydrogels exhibit remarkable efficacy preventing postoperative wound bleeding substantially enhancing safety resection. This research on system presents novel therapeutic addressing local cancer, potentially offering substantial contribution field surgical treatment future.

Language: Английский

Citations

11
Sustainable nanomaterials for precision medicine in cancer therapy DOI
Ashkan Bigham, Atefeh Zarepour, Arezoo Khosravi

et al.

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 27, P. 100865 - 100865

Published: May 27, 2024

Language: Английский

Citations

4
Research Progress on Dendritic Cells in Hepatocellular Carcinoma Immune Microenvironments DOI Creative Commons
Wenya Li, G Chen, Hailin Peng

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1161 - 1161

Published: Sept. 16, 2024

Dendritic cells (DCs) are antigen-presenting that play a crucial role in initiating immune responses by cross-presenting relevant antigens to initial T cells. The activation of DCs is step inducing anti-tumor immunity. Upon recognition and uptake tumor antigens, activated present these naive cells, thereby stimulating cell-mediated enhancing their ability attack tumors. It particularly noted able cross-present foreign major histocompatibility complex class I (MHC-I) molecules, prompting CD8+ proliferate differentiate into cytotoxic In the malignant progression hepatocellular carcinoma (HCC), inactivation plays an important role, anti-HCC immunotherapy. this review, we summarize mechanisms HCC, involved regulatory factors strategies activate HCC provides basis for study immunotherapy through activation.

Language: Английский

Citations

4