Organic Chemistry Frontiers,
Journal Year:
2018,
Volume and Issue:
5(22), P. 3250 - 3255
Published: Jan. 1, 2018
Here
we
report
the
first
base-metal
catalyzed
dehydrogenative
coupling
of
primary
(aromatic,
heteroaromatic,
and
aliphatic)
secondary
alcohols
with
methyl-N-heteroaromatics
to
form
various
C(sp3)-alkylated
N-heteroaromatics.
ACS Catalysis,
Journal Year:
2021,
Volume and Issue:
11(12), P. 7060 - 7069
Published: June 2, 2021
Controlling
the
selectivity
in
a
hydroamination
reaction
is
an
extremely
challenging
yet
highly
desirable
task
for
diversification
of
amines.
In
this
article,
selective
formal
anti-Markovnikov
allyl
alcohols
presented.
It
enables
versatile
synthesis
valuable
γ-amino
alcohol
building
blocks.
A
phosphine-free
Earth's
abundant
manganese(I)
complex
catalyzed
under
hydrogen-borrowing
conditions.
vast
range
aliphatic,
aromatic
amines,
drug
molecules,
and
natural
product
derivatives
underwent
successful
with
primary
secondary
allylic
excellent
functional
group
tolerance
(57
examples).
The
catalysis
could
be
performed
on
gram
scale
has
been
applied
molecules.
mechanistic
studies
revealed
metal–ligand
bifunctionality
as
well
hemilability
ligand
backbone
key
design
principle
success
catalysis.
Catalysis Science & Technology,
Journal Year:
2022,
Volume and Issue:
12(18), P. 5695 - 5702
Published: Jan. 1, 2022
The
synthesis
of
N-heterocycles
has
been
considered
an
emerging
area
chemical
research
due
to
their
extensive
utilization
in
pharmaceuticals,
materials
science,
and
natural
product
synthesis.
Angewandte Chemie International Edition,
Journal Year:
2018,
Volume and Issue:
57(41), P. 13444 - 13448
Published: Aug. 7, 2018
Abstract
We
have
developed
unprecedented
methods
for
the
direct
transformation
of
primary
alcohols
to
alkenes
in
presence
hydrazine,
and
synthesis
mixed
by
reaction
with
hydrazones.
The
reactions
are
catalyzed
a
manganese
pincer
complex
proceed
absence
added
base
or
hydrogen
acceptors,
liberating
dihydrogen,
dinitrogen,
water
as
only
byproducts.
proposed
mechanism,
based
on
preparation
intermediates
control
experiments,
suggests
that
occurs
through
metal–ligand
cooperative
N−H
activation
hydrazone
intermediate.
Chemical Communications,
Journal Year:
2018,
Volume and Issue:
54(87), P. 12369 - 12372
Published: Jan. 1, 2018
The
first
base-metal
catalysed
coupling
of
primary
alcohols
with
methyl-N-heteroaromatics
is
reported.
use
an
earth
abundant
and
nonprecious
NiBr2/L1
system
enables
access
to
a
series
C(sp3)-alkylated
N-heteroaromatics.
Mechanistic
studies
have
established
the
participation
hydrogen-borrowing
strategy
for
α-alkylation.
Organic Chemistry Frontiers,
Journal Year:
2018,
Volume and Issue:
5(22), P. 3250 - 3255
Published: Jan. 1, 2018
Here
we
report
the
first
base-metal
catalyzed
dehydrogenative
coupling
of
primary
(aromatic,
heteroaromatic,
and
aliphatic)
secondary
alcohols
with
methyl-N-heteroaromatics
to
form
various
C(sp3)-alkylated
N-heteroaromatics.
