Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: April 19, 2022
Abstract
Synthetic
molecular
machines
hold
tremendous
potential
to
revolutionize
chemical
and
materials
sciences.
Their
autonomous
motion
controlled
by
external
stimuli
allows
develop
smart
whose
properties
can
be
adapted
on
command.
For
the
realisation
of
more
complex
machines,
it
is
crucial
design
building
blocks
multiple
orthogonal
stimuli.
A
major
challenge
reversibly
switch
from
forward
backward
again
light-driven
rotary
using
Here
we
report
a
push-pull
substituted
photo-responsive
overcrowded
alkene
function
toggled
between
that
unidirectional
2
nd
generation
motor
depending
its
protonation
polarity
environment.
With
simplicity
in
design,
easy
preparation,
outstanding
stability
control
distinct
motions,
believe
present
concept
paves
way
for
creating
advanced
machines.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(22), P. 12377 - 12449
Published: Jan. 1, 2021
Molecular
photoswitches
are
inherently
lipophilic
and
do
not
spontaneously
dissolve
in
water.
We
describe
the
effect
of
water
on
photochemical
properties
strategies
to
solubilize
organic
apply
them
aqueous
media.
Chemical Science,
Journal Year:
2020,
Volume and Issue:
11(43), P. 11672 - 11691
Published: Jan. 1, 2020
This
perspective
article
explores
the
current
state
of
light-controlled
molecular
tools
for
medical
therapy
and
imaging
offers
an
outlook
on
clinical
application
scenarios
optimisation
strategies.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(10)
Published: Oct. 14, 2022
Photoresponsive
supramolecular
polymers
are
well-organized
assemblies
based
on
highly
oriented
and
reversible
noncovalent
interactions
containing
photosensitive
molecules
as
(co-)monomers.
They
have
attracted
increasing
interest
in
smart
materials
dynamic
systems
with
precisely
controllable
functions,
such
light-driven
soft
actuators,
photoresponsive
fluorescent
anticounterfeiting
light-triggered
electronic
devices.
The
present
review
discusses
light-activated
used
their
main
photo-induced
changes,
e.g.,
geometry,
dipole
moment,
chirality.
Based
these
distinct
formed
by
exhibit
disassembly
reassembly.
As
a
consequence,
polymerization,
"depolymerization,"
regulation
of
the
lengths
topologies
observed.
Moreover,
light-controlled
functions
polymers,
actuation,
emission,
chirality
transfer
along
length
scales,
highlighted.
Furthermore,
perspective
challenges
future
opportunities
is
presented.
Besides
challenge
moving
from
harmful
UV
light
to
visible/near
IR
avoiding
fatigue,
enabling
biomedical
applications,
include
actuators
helical
motion,
light-modulated
information
transmission,
optically
recyclable
materials,
multi-stimuli-responsive
systems.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(32), P. 13192 - 13202
Published: March 28, 2020
Abstract
Stiff‐stilbene,
a
sterically
restricted
fused
ring
analogue
of
stilbene,
has
been
regularly
used
as
model
compound
in
theoretical
studies
stilbene
photoisomerization.
Lately,
owing
to
its
excellent
photoswitching
properties,
it
is
increasingly
being
applied
reversibly
control
the
properties
and
function
chemical
well
biological
systems.
Stiff‐stilbene
photoswitches
possess
number
advantageous
including
high
quantum
yield
for
photoisomerization
thermal
stability.
Furthermore,
they
undergo
large
geometrical
change
upon
isomerization
their
synthesis
straightforward.
Herein,
we
provide
an
overview
basic
stiff‐stilbene
recent
applications
supramolecular
chemistry,
catalysis,
Joule,
Journal Year:
2021,
Volume and Issue:
5(12), P. 3116 - 3136
Published: Nov. 22, 2021
Some
molecular
photoisomers
can
be
isomerized
to
a
metastable
high-energy
state
by
exposure
light.
These
molecules
then
thermally
or
catalytically
converted
back
their
initial
state,
releasing
heat
in
the
process.
Such
reversible
photochemical
process
has
been
considered
for
developing
solar
thermal
(MOST)
systems.
In
this
review,
we
introduce
concept,
criteria,
and
state-of-the-art
of
MOST
systems,
with
an
emphasis
on
three
most
promising
systems:
norbornadiene/quadricyclane,
E/Z-azobenzene,
dihydroazulene/vinylheptafulvene.
After
discussing
fundamental
working
principles,
focus
design
strategies
improving
energy
storage
performance,
remaining
challenges,
potential
areas.
Finally,
summarize
current
incorporation
into
functional
devices
conclude
perspective
challenges
future
directions.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(13), P. 8530 - 8574
Published: June 21, 2023
Anionic
species
are
omnipresent
and
involved
in
many
important
biological
processes.
A
large
number
of
artificial
anion
receptors
has
therefore
been
developed.
Some
these
capable
mediating
transmembrane
transport.
However,
where
transport
proteins
can
respond
to
stimuli
their
surroundings,
creation
synthetic
with
stimuli-responsive
functions
poses
a
major
challenge.
Herein,
we
give
full
overview
the
stimulus-controlled
that
have
developed
thus
far,
including
application
membrane
In
addition
potential
operation
as
carriers,
use
recognition
motifs
forming
responsive
membrane-spanning
channels
is
discussed.
With
this
review
article,
intend
increase
interest
among
scientists
working
on
host–guest
complexes
dynamic
functional
systems
order
stimulate
further
developments.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(11), P. 3872 - 3878
Published: Jan. 1, 2024
Simple
structural
modifications
significantly
boost
the
photochromic
performance
of
imine-based
photoswitches.
This
work
lays
a
foundation
for
exploring
new
motifs
in
light-addressable
dynamic
combinatorial
chemistry.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(3), P. 1894 - 1903
Published: Jan. 11, 2024
Molecular
photoswitches
are
highly
desirable
in
all
chemistry-related
areas
of
research.
They
provide
effective
outside
control
over
geometric
and
electronic
changes
at
the
nanoscale
using
an
easy
to
apply,
waste-free
stimulus.
However,
simple
access
such
molecular
tools
is
typically
not
granted,
elaborate
syntheses
substitution
schemes
needed
order
obtain
efficient
photoswitching
properties.
Here
we
present
a
series
rhodanine-based
that
can
be
prepared
one
synthetic
step
without
requiring
purification.
Photoswitching
induced
by
UV
visible
light
both
switching
directions,
thermal
stabilities
metastable
states
as
well
quantum
yields
very
high.
An
additional
benefit
hydrogen-bonding
capacity
rhodanine
fragment,
which
enables
applications
supramolecular
or
medicinal
chemistry.
We
further
show
known
inhibitor
SMI-16a
photoswitchable
apoptosis
inducer.
The
biological
activity
effectively
switched
ON
OFF
reversible
photoisomerization
between
inactive
E
active
Z
isomer.
Rhodanine-based
therefore
represent
valuable
toolbox
for
implementing
responsiveness
breadth
functional
systems.
Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(8), P. 1111 - 1111
Published: July 27, 2020
The
concept
of
a
scaffold
concerns
many
aspects
at
different
steps
on
the
drug
development
path.
In
medicinal
chemistry,
choice
relevant
“drug-likeness”
is
starting
point
for
design
structure
dedicated
to
specific
molecular
targets.
For
years,
chemical
uniqueness
stilbene
has
inspired
scientists
from
fields
such
as
biology,
pharmacy,
and
medicine.
this
review,
we
present
outstanding
potential
stilbene-based
derivatives.
Naturally
occurring
stilbenes,
together
with
powerful
synthetic
chemistry
possibilities,
may
offer
an
excellent
approach
discovering
new
structures
identifying
their
therapeutic
With
scientific
tools,
sophisticated
equipment,
better
understanding
disease
pathogenesis
level,
moved
innovation
in
science.
This
paper
mainly
focuses
compounds
beyond
resveratrol,
which
are
particularly
attractive
due
biological
activity.
Given
“fresh
outlook”
about
stilbenoids
particular
regard
isorhapontigenin
methoxy-
hydroxyl-
analogues,
update
combretastatins,
very
often
overlooked
underestimated
benzanilide
story
remarkable
structure.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(48), P. 21663 - 21670
Published: Aug. 28, 2020
Molecular
photoswitches
enable
reversible
external
control
of
biological
systems,
nanomachines,
and
smart
materials.
Their
development
is
driven
by
the
need
for
low
energy
(green-red-NIR)
light
switching,
to
allow
non-invasive
operation
with
deep
tissue
penetration.
The
lack
clear
design
principles
adaptation
optimization
such
systems
limits
further
applications.
Here
we
provide
a
rulebook
tetra-ortho-chloroazobenzenes,
an
emerging
class
visible-light-responsive
photochromes,
elucidating
role
that
substituents
play
in
defining
their
key
characteristics:
absorption
spectra,
band
overlap,
photoswitching
efficiencies,
half-lives
unstable
cis
isomers.
This
achieved
through
joint
photochemical
theoretical
analyses
representative
library
molecules
featuring
varying
electronic
nature.
A
set
guidelines
presented
enables
tuning
properties
desired
application
informed
photochrome
engineering.
