Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
20(7), P. 3254 - 3277
Published: June 15, 2023
Hypoxia
is
a
key
impediment
encountered
in
the
treatment
of
most
solid
tumors,
leading
to
immune
escape
and
therapeutic
resistance.
Perfluorocarbons
(PFCs)
have
unique
electrical
structure
are
characterized
by
high
solubility
for
gases.
PFC-based
oxygen
carriers
been
evaluated
their
ability
deliver
effectively
hypoxic
tissues,
significant
clinical
translation
has
demonstrated.
And
due
acoustic
activity,
PFCs
employed
stabilize
injection
gas
microbubbles
(MBs)
as
ultrasonography
contrast
agents.
In
contrast,
ultrasound
photothermally
activatable
PFC
phase-shift
nanodroplets
(P-SNDs)
represent
novel
alternative
imaging
hypoxia
improvement.
The
may
be
utilized
improve
efficacy
cancer
treatments
based
on
synergistic
radiotherapy
(RT),
chemotherapy
(CMT),
photodynamic
therapy
(PDT)
reshape
tumor
microenvironment
through
immunotherapy
(IMT)
achieve
precise
diagnosis
using
imaging.
This
review
described
characteristics
provide
an
update
design
delivery
systems
used
facilitate
tumors.
objective
was
contribute
overcoming
obstacles
during
research
developing
prospects.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(1), P. 120 - 120
Published: Jan. 4, 2022
Photodynamic
therapy
(PDT),
in
which
a
light
source
is
used
combination
with
photosensitizer
to
induce
local
cell
death,
has
shown
great
promise
therapeutically
targeting
primary
tumors
negligible
toxicity
and
minimal
invasiveness.
However,
numerous
studies
have
that
noninvasive
PDT
alone
not
sufficient
completely
ablate
deep
tissues,
due
its
inherent
shortcomings.
Therefore,
depending
on
the
characteristics
type
of
tumor,
can
be
combined
surgery,
radiotherapy,
immunomodulators,
chemotherapy,
and/or
targeted
therapy,
preferably
patient-tailored
manner.
Nanoparticles
are
attractive
delivery
vehicles
overcome
shortcomings
traditional
photosensitizers,
as
well
enable
codelivery
multiple
therapeutic
drugs
spatiotemporally
controlled
Nanotechnology-based
strategies
provided
inspiration
improve
anticancer
effects
PDT.
Here,
we
briefly
introduce
mechanism
summarize
photosensitizers
been
tested
preclinically
for
various
cancer
types
clinically
approved
treatment.
Moreover,
discuss
current
challenges
facing
treatment
options,
highlight
opportunities
nanoparticle-based
therapies.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(29)
Published: Aug. 24, 2022
Independent
of
tumor
type
and
non-invasive
or
minimally-invasive
feature,
current
physical
treatments
including
ultrasound
therapy,
microwave
ablation
(MWA),
radiofrequency
(RFA)
are
widely
used
as
the
local
treatment
methods
in
clinics
for
directly
killing
tumors
activating
systematic
immune
responses.
However,
activated
responses
inadequate
incompetent
recession,
incomplete
thermal
even
aggravates
immunosuppressive
microenvironment
(ITM),
resulting
intractable
recurrence
metastasis.
Intriguingly,
nanomedicine
provides
a
powerful
platform
they
can
elevate
energy
utilization
efficiency
augment
oncolytic
effects
mitigating
ITM
potentiating
Especially
after
combining
with
clinical
immunotherapy,
anti-tumor
effect
by
enhancing
human
system
is
reached,
enabling
effective
prevention
against
This
review
systematically
introduces
cutting-edge
progress
direction
nanobiotechnologies
their
corresponding
nanomaterials.
Moreover,
enhanced
progression,
relapse,
metastasis
via
autologous
immunity
exogenous
immunotherapeutic
agents
exemplified,
rationales
analyzed.
offers
general
guidance
directions
to
enhance
from
perspectives
activation
magnification.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(26)
Published: Aug. 4, 2023
Abstract
The
application
of
nanomaterials
in
healthcare
has
emerged
as
a
promising
strategy
due
to
their
unique
structural
diversity,
surface
properties,
and
compositional
diversity.
In
particular,
have
found
significant
role
improving
drug
delivery
inhibiting
the
growth
metastasis
tumor
cells.
Moreover,
recent
studies
highlighted
potential
modulating
microenvironment
(TME)
enhancing
activity
immune
cells
improve
therapy
efficacy.
Various
types
are
currently
utilized
carriers,
immunosuppressants,
activators,
immunoassay
reagents,
more
for
immunotherapy.
Necessarily,
used
immunotherapy
can
be
grouped
into
two
categories:
organic
inorganic
nanomaterials.
Though
both
shown
ability
achieve
purpose
immunotherapy,
composition
properties
result
differences
mechanisms
modes
action.
Organic
further
divided
polymers,
cell
membranes,
nanoemulsion‐modified,
hydrogel
forms.
At
same
time,
broadly
classified
nonmetallic
metallic
current
work
aims
explore
action
these
different
prospects
promoting
Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
20(7), P. 3254 - 3277
Published: June 15, 2023
Hypoxia
is
a
key
impediment
encountered
in
the
treatment
of
most
solid
tumors,
leading
to
immune
escape
and
therapeutic
resistance.
Perfluorocarbons
(PFCs)
have
unique
electrical
structure
are
characterized
by
high
solubility
for
gases.
PFC-based
oxygen
carriers
been
evaluated
their
ability
deliver
effectively
hypoxic
tissues,
significant
clinical
translation
has
demonstrated.
And
due
acoustic
activity,
PFCs
employed
stabilize
injection
gas
microbubbles
(MBs)
as
ultrasonography
contrast
agents.
In
contrast,
ultrasound
photothermally
activatable
PFC
phase-shift
nanodroplets
(P-SNDs)
represent
novel
alternative
imaging
hypoxia
improvement.
The
may
be
utilized
improve
efficacy
cancer
treatments
based
on
synergistic
radiotherapy
(RT),
chemotherapy
(CMT),
photodynamic
therapy
(PDT)
reshape
tumor
microenvironment
through
immunotherapy
(IMT)
achieve
precise
diagnosis
using
imaging.
This
review
described
characteristics
provide
an
update
design
delivery
systems
used
facilitate
tumors.
objective
was
contribute
overcoming
obstacles
during
research
developing
prospects.
