Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 647, P. 134 - 141
Published: May 9, 2023
Language: Английский
Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(30)
Published: March 21, 2023
Molecular probes which can be modulated, functionalized and used to visualize the processes are highly desirable for understanding manipulating biological systems. Geometric cis trans isomers of tetraphenylethene (TPE) emerge as attractive candidates fulfill these tasks thanks unique aggregation-induced emission properties, tailorable structures, responsiveness external stimuli. This minireview focuses on TPE derivatives that with molecular recognition units fluorescence detection, bioimaging cancer therapy. The effects geometry property, target binding ability activity summarized. feasibility in vitro vivo switch configuration thus bio-activity is discussed. Finally, future development challenges discussed view TPE-based stereoisomers targeted sensing imaging-guided modulation processes.
Language: Английский
Citations
12
Chemical Science, Journal Year: 2023, Volume and Issue: 14(19), P. 5106 - 5115
Published: Jan. 1, 2023
Self-assembly of amphiphilic photosensitizer BDQ into BDQ-NP enables stable incorporation lysosome membranes to cause continuous lysosomal membrane permeabilization for highly effective photodynamic therapy.
Language: Английский
Citations
12
Analytical and Bioanalytical Chemistry, Journal Year: 2023, Volume and Issue: 415(18), P. 4079 - 4092
Published: May 26, 2023
Language: Английский
Citations
11
Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.
Language: Английский
Citations
4
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
ABSTRACT The aberrant behavior of lipid droplets (LDs) is often indicative cellular dysfunction, which may contribute to the development a range diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and atherosclerosis (AS). Consequently, there an urgent need develop fluorescence probes targeting LDs monitor progression disease. In this study, unanticipated one‐pot boron tribromide (BBr₃)/boron trichloride (BCl₃)‐promoted cyclization reaction was discovered, yielding bromo‐/chloro‐substituted triphenylamine (TPA) derivative ( TPA‐Br / TPA‐Cl ). successfully transformed into new TPA‐containing donor‐acceptor (D–A) molecules show typical aggregation induced emission (AIE) property. Among these AIE emitters, TPA‐N shows most promising specificity, lowest toxicity best photo‐stability. Ex vivo studies further demonstrate that can be used image fatty AS plaque quickly effectively.
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Intracellular monitoring of protein ubiquitination and differentiating polyubiquitin chain topology are crucial for understanding life processes drug discovery, which is challenged by the high complexity process a lack molecular tools. Herein, synthetic dual-sensor platform specific K48-linked ubiquitin oligomers was tailored in situ visualization assembling live biosystems. This achieved using macrocyclic peptides as recognition motifs tetraphenylethylene derivative an activatable reporter. The efficient cell penetration, tight binding, protection delivered "freeze-and-image" approach, allowing fluorescent readout linkage type elongation without perturbing physiological environment. Motivated these unique features, mapping K48-ubiquitination dynamics during degradation facilely achieved. Rapid, sensitive, intracellular assessment mechanism action potency dependence proteolysis-targeting chimeras (PROTACs) demonstrated, presenting sensors promising tools PROTAC development.
Language: Английский
Citations
0
Science Advances, Journal Year: 2025, Volume and Issue: 11(8)
Published: Feb. 19, 2025
Osteoporosis and bone injury healing in elderly patients are major medical challenges, often exacerbated by the accumulation of senescent cells. Herein, we show that TPE-Gal, which contains a tetraphenylethene unit galactose moiety, offers promising molecular therapy designed to light up eliminate cells through hydrolysis reaction catalyzed β-galactosidase, an enzyme overexpressed The produces TPE-OH, which, turn, increases reactive oxygen species levels within cells, leading noninflammatory apoptosis This targeted clearance mechanism helps alleviate osteoporosis symptoms promotes healing. Moreover, apoptotic vesicles, generated during process, partly phagocytosed macrophages, mimicking physiological metabolic processes. study opens new avenues for addressing health issues bioclearance aligning with body’s natural pathways maintaining homeostasis.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(11)
Published: Oct. 5, 2023
Abstract Simultaneously adding multiple drugs and other chemical reagents to individual droplets at specific time points presents a significant challenge, particularly when dealing with tiny in high‐throughput screening applications. In this study, micropatterned polymer chip is developed as miniaturized platform for light‐induced programmable drug addition cell‐based screening. This incorporates porous superhydrophobic film atom transfer radical polymerization reactivity, facilitating the efficient grafting of azobenzene methacrylate, photoconformationally changeable group, onto hydrophilic regions matrix targeted locations precise densities. By employing light irradiation, cyclodextrin‐azobenzene host–guest complexes formed on can switch from an “associated” “dissociated” state, granting photochemical control over supramolecular coding system its surface patterning ability. Significantly, exceptional spatial temporal offered by these transitions empowers utilize digital processing systems simultaneous regulation release cyclodextrin‐bearing across numerous containing suspended or adhered cells. approach minimizes mechanical disruption while achieving timing addition, dosage, integration varieties released screening, all meet requirements.
Language: Английский
Citations
10
Biosensors, Journal Year: 2023, Volume and Issue: 13(9), P. 838 - 838
Published: Aug. 23, 2023
Specific identification and monitoring of senescent cells are essential for the in-depth understanding regulation senescence-related life processes diseases. Fluorescent sensors providing real-time in situ information with spatiotemporal resolution unparalleled tools have contributed greatly to this field. This review focuses on recent progress fluorescent molecularly targeted imaging tracking cellular senescence. The molecular design, sensing mechanisms, biological activities discussed. categorized by types markers targeting ligands. Accordingly, their recognition performance towards senescence biomarkers summarized. Finally, perspective challenges field discussed, which expected assist future design next-generation
Language: Английский
Citations
9
Talanta, Journal Year: 2023, Volume and Issue: 268, P. 125311 - 125311
Published: Oct. 14, 2023
Language: Английский
Citations
8