An Asymmetric Bacterial Cellulose Membrane Incorporating CuPt Nanozymes and Curcumin for Accelerating Wound Healing DOI
Lei Li, Haoze Li, Junrong Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Damaged skin compromises its ability to effectively prevent the invasion of harmful bacteria into tissue, leading bacterial infection wound and hindering healing process. To address this challenge, we have developed a multifunctional asymmetric dressing (CuPt-Cur-ABC) that addresses lack bactericidal activity release active ingredients in conventional cellulose (BC), which can be employed create barrier defense between surrounding environment. Compared with BC, (ABC) used starch as pore-causing agent, forming holes different sizes at top bottom, enhanced ABC load moderate-release drugs. First, as-synthesized CuPt nanozymes an octopod nanoframe structure had multiple enzymatic activities including peroxidase-like, catalase-like, glutathione peroxidase-like activities. Then, curcumin (Cur) were loaded under ultrasound. Under 808 nm laser irradiation, nanocomposites possessed good photothermal properties. So therapy combined chemodynamic inherent antibacterial performance Cur achieved 99.3% 99.6%

Language: Английский

Nitric Oxide‐Actuated Titanium Dioxide Janus Nanoparticles for Enhanced Multimodal Disruption of Infectious Biofilms DOI
Weichen Zhao, Qihang Ding, Bingshuai Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: June 28, 2024

Abstract Sonodynamic therapy (SDT) is promising for combating deep‐seated infectious diseases by generating substantial reactive oxygen species (ROS) through the profound tissue penetration capabilities of ultrasound. However, compact protective structures bacterial biofilms present a formidable challenge, impeding ROS efficacy. Given that have limited diffusion range and current sonosensitizers struggle to infiltrate biofilms, complete eradication pathogenic bacteria often remains unachieved. In this study, mesoporous titanium dioxide (TiO 2 ) nanoparticles are engineered asymmetrically coated with thin layer Ag loaded L‐arginine (LA) construct ultrasound‐propelled nanomotors. These Ag‐TiO ‐LA Janus demonstrate robust self‐propulsion upon ultrasonic activation, allowing deeper into biofilm matrices enhancing localized disruption improved SDT outcomes. Additionally, incorporation not only broadens TiO ’s absorption spectrum but also confers photothermal NIR laser excitation at 808 nm. The nanomotor amalgamates sonodynamic potential Ag's properties, forging versatile antimicrobial agent capable efficient synergistic antibacterial effect when subjected dual ultrasound stimuli. This innovative, singularly‐structured nanoparticle stands out as an effective combatant against accelerates healing process infected wounds, showcasing multifaceted clinical applications.

Language: Английский

Citations

11
Advancements of Porphyrin‐Derived Nanomaterials for Antibacterial Photodynamic Therapy and Biofilm Eradication DOI Open Access
Suwen Chen,

Baoxuan Huang,

Jia Tian

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: July 27, 2024

Abstract The threat posed by antibiotic‐resistant bacteria and the challenge of biofilm formation has highlighted inadequacies conventional antibacterial therapies, leading to increased interest in photodynamic therapy (aPDT) recent years. This approach offers advantages such as minimal invasiveness, low systemic toxicity, notable effectiveness against drug‐resistant bacterial strains. Porphyrins their derivatives, known for high molar extinction coefficients singlet oxygen quantum yields, have emerged crucial photosensitizers aPDT. However, practical application is hindered challenges poor water solubility aggregation‐induced quenching. To address these limitations, extensive research focused on development porphyrin‐based nanomaterials aPDT, enhancing efficacy sterilization broadening range antimicrobial activity. review provides an overview various utilized aPDT eradication years, including porphyrin‐loaded inorganic nanoparticles, polymer assemblies, supramolecular metal–organic frameworks (MOFs), covalent organic (COFs). Additionally, insights into prospects offered, highlighting its potential implementation.

Language: Английский

Citations

11
An NIR Type I Photosensitizer Based on a Cyclometalated Ir(III)-Rhodamine Complex for a Photodynamic Antibacterial Effect toward Both Gram-Positive and Gram-Negative Bacteria DOI
Chuangjun Liu, Qihang Ding,

Y. B. Liu

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(28), P. 13059 - 13067

Published: June 28, 2024

Type I photosensitizers offer an advantage in photodynamic therapy (PDT) due to their diminished reliance on oxygen levels, thus circumventing the challenge of hypoxia commonly encountered PDT. In this study, we present synthesis and comprehensive characterization a novel type photosensitizer derived from cyclometalated Ir(III)-rhodamine complex. Remarkably, complex exhibits shift absorption fluorescence, transitioning "off" "on" states aprotic protic solvents, respectively, contrary initial expectations. Upon exposure light, demonstrates effective generation O2– ·OH radicals via mechanism. Additionally, it notable antibacterial activity against both Gram-positive Gram-negative bacteria, demonstrated through vitro vivo experiments. This research offers valuable insights for development photosensitizers.

Language: Английский

Citations

10
Antibiotic adjuvants against multidrug-resistant Gram-negative bacteria: important component of future antimicrobial therapy DOI
Wenwen Li, Zhen Tao,

Motan Zhou

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 287, P. 127842 - 127842

Published: July 18, 2024

Language: Английский

Citations

5
Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants DOI Creative Commons
Siqi Jin,

Yameng Yu,

Ting Zhang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 404 - 432

Published: Sept. 10, 2024

Language: Английский

Citations

5
A noval iron-capturing nanocomposites against biofilms for disrupting bacterial nutritional balance DOI

Jinying Lin,

Qihang Ding, Yao Sun

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(6), P. 1760 - 1761

Published: April 7, 2024

Language: Английский

Citations

4
Semiconducting Perylene Diimide J‐aggregates Cross‐linked Hydrogel Enables High‐Efficiency Photothermal Controlled Release of Nitric Oxide for Antibiofilm Therapy DOI Open Access

Kangxin Zhang,

Bo Wang,

Fengwei Sun

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Antibiofilm treatment, particularly drug-containing wound healing dressings, does not typically penetrate the robust protective extracellular polymeric substance of biofilm and eradicate bacteria. Here, a rational design nitric oxide (NO) donor N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine (BNN6)-based injectable hydrogel, is reported in which NO release can be triggered by photothermal effect owing to semiconducting perylene diimide (PDI) J-aggregation fibers. The synthetic PDI derivatives self-assembling into 0D nanoparticles then aggregating 1D J fiber accompanied absorbance red-shifting from 700 790 nm 852 nm. After encapsulating BNN6, "sandwich roll" (SR) like structure evenly crosslinked an hydrogel (SRH) exhibiting high convenience efficiency 72%, enables SRH achieve highly efficient photocontrol release. shows excellent injectability, shape adaptability, effective antibacterial efficacy over 99% E.coli S. aureus. remarkable vivo antibiofilm 99.58% laser irradiation. Furthermore, synergistic treatment displays ability eliminate inflammation, facilitate angiogenesis, promote collagen deposition, thereby significantly stimulating process wounds. versatile strategy for biofilm.

Language: Английский

Citations

0
Insights into biofilm-mediated mechanisms driving last-resort antibiotic resistance in clinical ESKAPE pathogens DOI
Christina Shook Cheng Chong, Yin Yin Lau, Paul A.M. Michels

et al.

Critical Reviews in Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: March 17, 2025

The rise of antibiotic-resistant bacteria poses a grave threat to global health, with the ESKAPE pathogens, which comprise Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. being among most notorious. World Health Organization has reserved group last-resort antibiotics for treating multidrug-resistant bacterial infections, including those caused by pathogens. This situation calls comprehensive understanding resistance mechanisms as it threatens public health hinder progress toward Sustainable Development Goal (SDG) 3: Good Well-being. present article reviews mechanisms, focusing on emerging mutations in particularly against antibiotics, describes role biofilm formation It discusses latest therapeutic advances, use antimicrobial peptides CRISPR-Cas systems, modulation quorum sensing iron homeostasis, offer promising strategies countering resistance. integration CRISPR-based tools biofilm-targeted approaches provides potential framework managing infections. By highlighting spread current approaches, review aims contribute significantly advancing our combatting this pressing challenge.

Language: Английский

Citations

0
Gallium‐Magnesium Layered Double Hydroxide for Elevated Tumor Immunotherapy Through Multi‐Network Synergistic Regulation DOI
Jia Tan, Binbin Ding, Hao Chen

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Immunotherapeutic efficacy is often limited by poor immunogenicity, immunosuppressive tumor microenvironment (TME), and cytoprotective mechanisms, leading to low immune activation. To this end, here, L‐amino acid oxidase (LAAO) loaded gallium‐magnesium layered double hydroxide (MG‐LAAO) prepared for significantly enhanced immunotherapy through multi‐network synergistic regulation. First, MG‐LAAO induces cell pyroptosis initiating caspase‐1/GSDMD caspase‐3/GSDME pathways, further triggering immunogenic death (ICD). Then the released Ga 3+ mitochondrial iron overload, resulting in ferroptosis. In addition, also hinders autophagy of cells, reshapes (TME) neutralizing H + inhibiting lactic accumulation, thus destroying mechanism avoiding escape. Furthermore, synergy activates cGAS‐STING signaling pathway, generating powerful antitumor immunotherapy. This work highlights critical role synergies between block, pyroptosis, ferroptosis, ICD immunotherapy, demonstrating important effectively overcoming TME enhancing immunogenicity. particular, gallium‐induced revealed first time, providing theoretical support design new materials future.

Language: Английский

Citations

0
Recent Advances in Crystalline Porous Materials for Antibacterial Applications DOI

Peijie Wu,

Liangming Wei,

Rui Yao

et al.

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Bacterial infections remain a significant and escalating threat to global health, exacerbated by multidrug‐resistant strains that undermine the efficacy of conventional antibiotics. This pressing issue underscores urgent need for development new antimicrobial materials. Among these, molecular‐based crystalline porous materials, such as metal–organic frameworks (MOFs), covalent organic (COFs), hydrogen‐bonded (HOFs), supramolecular assembly (SAFs), have emerged promising class antibacterial agents. These materials exhibit well‐defined crystallinity tunable structures, offering exceptional versatility applications. Notably, their high surface area, adjustable pore size, potential functionalization enable efficient loading controlled release agents, including metal ions molecules. review provides comprehensive analysis recent advancements in this field, highlighting design strategies, structural diversity, mechanisms, Finally, we discuss current challenges outline future opportunities practical deployment

Language: Английский

Citations

0