Anticancer Efficacy of Decursin: A Comprehensive Review with Mechanistic Insights DOI Creative Commons

Tanzila Akter Eity,

Md. Shimul Bhuia, Raihan Chowdhury

et al.

Future Pharmacology, Journal Year: 2025, Volume and Issue: 5(2), P. 17 - 17

Published: April 10, 2025

Introduction: Decursin is a pyranocoumarin natural phytochemical found in the Angelica gigas Nakai herb, which shows various therapeutic properties and beneficial effects against diseases. Objective: The aim of this study was to find anticancer potential decursin its molecular mechanisms involved with different effects. Methodology: All relevant data concerning compound cancer were collected using scientific search engines, including PubMed, Scopus, Springer Link, Wiley Online, Web Science, Scifinder, ScienceDirect, Google Scholar. Results: This that through mechanisms, such as apoptosis, cell cycle arrest, inhibition proliferation, autophagy, angiogenesis, cytotoxicity, invasion migration number cancers, breast, bladder, lung, colon, skin, ovarian, prostate, pancreatic, bone cancers. also discovered has ability affect several signaling pathways PI3K/AKT/mTOR, JAK/STAT, MAPK pathways. Findings revealed expresses poor oral bioavailability. Conclusions: Based on analysis from literature-based study, be considered candidate treatment cancer. However, more clinical research suggested establish proper efficacy, safety, human dosage.

Language: Английский

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study DOI
Md. Shimul Bhuia, Raihan Chowdhury, Fatema Akter Sonia

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 21(2)

Published: Dec. 27, 2023

Abstract Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with multitude of pharmacological activities. The primary emphasis this study on summarizing the anticancer properties underlying mechanisms RA and its derivatives, as well pharmacokinetic features. Data was collected (up to date November 10, 2023) from various reliable authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. findings imply that synthetic derivatives possess promising anti‐cancer against breast, colorectal, liver, cervical cancers preclinical test systems. results also indicate demonstrated effects via number cellular mechanisms, apoptotic cell death, inhibition oxidative stress, anti‐inflammatory effect, cytotoxicity, cycle arrest, anti‐proliferative anti‐angiogenic cancer migration invasion. It has been proposed derived compounds have capability serve hopeful chemotherapeutic agent, so further extensive clinical research necessary.

Language: Английский

Citations

17
Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies DOI Creative Commons

Mst. Farjanamul Haque,

Heba A. S. El‐Nashar, Md. Showkoth Akbor

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: April 16, 2024

Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in chick model. Additionally, silico studies were performed the molecular interactions with cyclooxygenase-2 (COX-2). Methods: The tested groups received (12.5, 25, 50 mg/kg) standard drugs celecoxib ketoprofen (42 via oral gavage prior formalin injection. Then, number licks was counted for first 10 min, paw edema diameter measured at 60, 90, 120 min. Results Discussion: significantly ( p < 0.05) reduced diameters, compared negative control. When combined celecoxib, it inflammatory parameters more effectively than individual groups. showed promising binding capacity COX-2. Taken together, exerted effects dose-dependent manner, possibly through COX-2 interaction pathway.

Language: Английский

Citations

8
Industrial and Environmental Applications of Plant-Derived Saponins: An Overview and Future Prospective DOI
Rasanpreet Kaur,

Vidhi Mishra,

Saurabh Gupta

et al.

Journal of Plant Growth Regulation, Journal Year: 2024, Volume and Issue: 43(9), P. 3012 - 3026

Published: Jan. 5, 2024

Language: Английский

Citations

7
Mikania micranthaKunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential DOI Open Access

Muahmmad Ali Khan,

Dina M. El‐Kersh, Md. Shafiqul Islam

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(11)

Published: Sept. 16, 2023

Mikania micrantha is utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches skin, chicken pox, healing sores wounds, colds fever, nausea, jaundice, rheumatism, respiratory ailments. This study aimed at summarizing traditional uses, phytochemical profile, biological activities M. based on obtainable information screened from different databases. An up-to-date search was performed in PubMed, Science Direct, clinicaltrials.gov, Google Scholar databases with specific keywords. No language restrictions were imposed. Published articles, theses, seminar/conference papers, abstracts, books ethnobotany, phytochemistry pharmacological evidence considered. Based inclusion criteria, this includes 53 published records above-mentioned The results suggest that fresh leaves whole plant are frequently used folk medicine. contains more than 150 phytochemicals under following groups: essential oils, phenolics flavonoids, terpenes, terpene lactones, glycosides, sulfated flavonoids. It carbohydrates micronutrients vitamins major trace minerals. possesses antioxidant, anti-inflammatory, anti-microbial, anti-dermatophytic, anti-protozoal, anthelmintic, cytotoxic, anxiolytic, anti-diabetic, lipid-lowering antidiabetic, spasmolytic, memory-enhancing, wound-healing, anti-aging, thrombolytic activities. clinical studies have been reported to date. might be one potential sources phytotherapeutic compounds against diverse humans. Studies required confirm its safety profile experimental animals prior initiating trials. Moreover, adequate investigation also crucial clarify exact mechanism action each effect.

Language: Английский

Citations

15
HPLC-ESI/MS-MS characterization of compounds in Dolomiaea costus extract and evaluation of cytotoxic and antiviral properties: molecular mechanisms underlying apoptosis-inducing effect on breast cancer DOI Creative Commons
Heba A. S. El‐Nashar, Omayma A. Eldahshan, Nasra F. Abdel Fattah

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 6, 2023

Dolomiaea costus (syn: Saussurea costus; Family Asteraceae) occupies an important place in the traditional Chinese medicinal plants and is prescribed for a wide range of disorders. The current study aimed to tentatively identify phytoconstituents D. extract explore antiproliferative activity against human breast cancer cells its possible apoptotic mechanism along with antiviral adenovirus 5 (Adv-5).The 70% ethanol were assessed using HPLC/ESI-MS/MS technique. cell viability was investigated line (MCF-7) via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Mechanistically, effects on Bax, Bcl2 Caspase 3 determined quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR). Further, Adv-5 based virucidal adsorption mechanisms.The HPLC/MS analysis revealed tentative identification twenty compounds polyphenolic nature, mainly flavonoids, lignans, coumarins, anthocyanidins. plant showed cytotoxic effect MCF-7 Vero IC50 values 15.50 44 µg/ml, respectively, indicating aggressiveness proliferation as confirmed by genes expression which upregulation Bax but further insight needed exact mechanistic pathway. Antiviral observed at non-toxic concentration tested extract.Such observations viral replication supported studies nanoformulations drug delivery systems targeting therapy vivo before biomedical applications.

Language: Английский

Citations

15
Sclareol antagonizes the sedative effect of diazepam in thiopental sodium-induced sleeping animals: In vivo and in silico studies DOI Open Access

Sm Hafiz Hassan,

Heba A S El-Nashar,

Md. Anisur Rahman

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116939 - 116939

Published: June 12, 2024

Sclareol (SCL), a labdane diterpene compound found in Salvia sclarea L., exhibited therapeutic effects. This study investigated the potential interaction between SCL and diazepam (DZP) modulating sedation thiopental sodium-induced sleeping animal model, supported by in-silico molecular docking analysis.

Language: Английский

Citations

5
Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms DOI Creative Commons

Tanzila Akter Eity,

Md. Shimul Bhuia, Raihan Chowdhury

et al.

Journal of Tropical Medicine, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties was beneficial numerous degenerative diseases by preventing lipid peroxidation. Quercetin is different diseases, such as atherosclerosis chronic inflammation. This study aims to find out anticancer activities quercetin determine mechanisms pathways which are responsible for effect. It also revealed biopharmaceutical, toxicological characteristics, clinical utilization evaluate its suitability further investigations reliable drug. All relevant data concerning this compound with cancer collected using scientific search engines, including PubMed, Springer Link, Wiley Online, Web Science, SciFinder, ScienceDirect, Google Scholar. review demonstrated that strong properties, apoptosis, inhibition cell proliferation, autophagy, cycle arrest, angiogenesis, invasion migration against various types cancer. Findings could significantly moderate regulate pathways, PI3K/AKT‐mTORC1 pathway, JAK/STAT signaling system, MAPK MMP NF‐ κ B p‐Camk2/p‐DRP1 pathway. However, poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation quercetin). Moreover, expressed no toxic effect investigated subjects. Based on view these findings, it might be considered chemotherapeutic drug candidate treatment cancers. more studies suggested establish proper efficacy, safety, human dose.

Language: Английский

Citations

5
Phytochemical analysis and biological investigation of Cheilanthes tenuifolia (Burm.f.) Swartz DOI Creative Commons

Umme Habiba Juhi,

Heba A. S. El‐Nashar, Abdullah Al Faruq

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 4, 2024

Introduction: Cheilanthes tenuifolia is an evergreen ornamental small fern, belonging to the family Pteridaceae, that grows in warm and rocky regions worldwide. Many species of genus are evidently endowed with important phytochemicals bioactivities. This study aimed perform a preliminary phytochemical analysis leaves alongside evaluation free radical scavenging, anti-inflammatory, antimicrobial, clot lysis activities extract fractions. Materials methods: A was done after fractionation ethanolic (ECT) n -hexane (HCT) chloroform (CCT). Then, 2,2-diphenyl-1-picrylhydrazyl (DPPH) egg albumin RBC membrane stabilization tests, disc diffusion, human blood assays were performed. Results: Phytochemical investigations suggested plant rich alkaloids, glycosides, tannins, flavonoids. All obtained fractions exhibited concentration-dependent inhibition protein denaturation capacities. Except for antifungal ECT better DPPH antibacterial, capacities than HCT CCT However, all mild anti-inflammatory activity. Conclusion: C. might be good source antioxidant, anti-microbial, anti-atherothrombotic agents. Further studies required isolate characterize active principles liable each bioactivity, along possible molecular interactions.

Language: Английский

Citations

4
Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms DOI
Md. Shimul Bhuia, Raihan Chowdhury, Manik Chandra Shill

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(7)

Published: May 17, 2024

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate hepatoprotective effect of FA and its derivatives (methyl ferulic trans-ferulic acid) against oxidative stress inflammation-related hepatotoxicity due toxicants based on results different non-clinical preclinical tests. For this, data was collected from reliable electronic databases such as PubMed, Google Scholar, ScienceDirect, etc. The this investigation demonstrated that have potent effects damage. findings also revealed these protective are antioxidant anti-inflammatory chemical compound. analogues significantly inhibit free radical generation hinder proinflammatory markers inflammatory enzymes, resulting diminished cytotoxic apoptotic hepatocyte death. compounds prevent intracellular lipid accumulation provide effects.

Language: Английский

Citations

4
Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer DOI Creative Commons
Md. Shimul Bhuia, Raihan Chowdhury, Meher Afroz

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

ABSTRACT Hinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the Cupressaceae family, possesses important biological activities, including an anticancer effect. This review summarizes its potential and draws possible molecular interventions. In addition, it evaluates biopharmaceutical, toxicological properties, clinical application of HK establish viability for future advancement as dependable medication. The assessment is based on most recent information available from various databases. Findings demonstrate substantial therapeutic advantages against diverse types cancer (colon, cervical, breast, bone, endometrial, liver, prostate, oral, skin) through mechanisms. induces oxidative stress, cytotoxicity, apoptosis, cell‐cycle arrest at G S phases, autophagy modulation phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target rapamycin (mTOR), p38/ERK/MAPK, nuclear factor kappa B, c‐Jun N‐terminal kinase signaling pathways. Furthermore, this compound exhibits good oral bioavailability with excellent plasma clearance. Clinical uses without any significant negative effects. A thorough study pertinent data suggests may serve viable candidate developing novel therapies. Consequently, more extensive studies are necessary evaluate treatment efficacy, safety, long‐term hazards.

Language: Английский

Citations

0