Role of the intratumoral microbiome in tumor progression and therapeutics implications DOI

Yufan Meng,

Zhiyao Fan, Bin Zhou

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 189014 - 189014

Published: Nov. 1, 2023

Language: Английский

Bile-Liver phenotype: Exploring the Microbiota Landscape in Bile and Intratumor of Cholangiocarcinoma DOI Creative Commons

Lei Wang,

Hui Zhao, Fan Wu

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Cholangiocarcinoma (CCA) arises within the peritumoral bile microenvironment, yet microbial translocation from to intracholangiocarcinoma (IntraCCA) tissues remains poorly understood. Previous studies on microbiota alterations biliary benign disease (BBD) CCA have yielded inconsistent results, highlighting need for cross-study analysis. We presented a comprehensive analysis of five cohorts (N = 266), including our newly established 16S rRNA gene profiling (n 42), elucidate these transitions. The concordance bacteria between and intraCCA tissue, represented by Enterococcus Staphylococcus, suggested migration intratumoral tissues. A computational random forest machine learning model effectively distinguished tissue bile, identifying Rhodococcus Ralstonia as diagnostically significant. also excelled in differentiating BBD achieving an AUC value 0.931 external validation. Using unsupervised hierarchical clustering, we Biletypes based signatures cohort. combination 17 genera stratified patients into Biletype B. B robustly discerned BBD, with Sub-Biletype B1 correlating advanced TNM stage poorer prognosis. Among genera, bacterial Cluster 1, composed Sphingomonas, Massilia, Paenibacillus, Porphyrobacter, Lawsonella, Aerococcus, was enriched predicted 0.96. Staphylococcus emerged promising single-genus predictor diagnosis staging. In conclusion, this study delineates potential transition pathway gut through intra-CCA proposing biomarkers

Language: Английский

Citations

0
Intratumoral microbiota for hepatocellular carcinoma: from preclinical mechanisms to clinical cancer treatment DOI Creative Commons
Muhua Chen,

Lei Bie

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 17, 2025

Intratumoral microbiota has been found to be a crucial component of hepatocellular carcinoma (HCC). Due insufficient recognition, technical limitations, and low biomass intratumoral microbiota, it is poorly understood. exhibit significant diversity in HCC tissues. It involved the development through several mechanisms, such as remodeling immunosuppressive microenvironment, metabolic reprogramming, genetic alterations. Moreover, associated with metastasis cells. Herein, we reviewed history applied biotechnology depict signatures investigated potential sources assessed their functions, heterogeneity. Furthermore, this review, summarized therapeutics that can used treatment proposed future perspectives for research field.

Language: Английский

Citations

0
Deciphering cGAS-STING signaling: implications for tumor immunity and hepatocellular carcinoma DOI
Harish C. Chandramoorthy,

Raed Obaid Saleh,

Farag M. A. Altalbawy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

Citations

0
Therapeutic Response-Driven Discrepancies in Intratumoral Microbiome Composition of Hepatocellular Carcinoma Following Conversion Therapy DOI
Lin Ma,

Jiamei Xu,

Fuhai Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Hepatocellular carcinoma, frequently detected late, constrains therapeutic interventions; contemporary conversion therapies enhance surgical eligibility and survival. While intratumoral microbiota is known to influence the tumor microenvironment, its alterations following interventions remain underexplored. This study (NCT06365034) included patients with initially unresectable HCC using therapy two or three modalities: immune checkpoint inhibitors (ICIs), tyrosine kinase (TKIs), locoregional such as transarterial chemoembolization (TACE) hepatic arterial infusion chemotherapy (HAIC). Effectiveness indicators rate (38.1%), objective response (44.4%), disease control (90.1%), radical (R0) resection (100%) safety. Microbial profiling of hepatocellular carcinoma tissues stratified by pathological (major [pMajR] vs minor [pMinR] responders) revealed distinct ecological patterns. pMinR specimens exhibited higher α-diversity (Wilcoxon, p < 0.05) β-diversity divergence (PCoA), enrichment Acidobacteriota/Chloroflexi phyla Halomonas/Arthrobacter genera. pMajR tumors demonstrated dominance Proteobacteria/Bacteroidetes elevated abundance Escherichia-Shigella/Limosilactobacillus Linear discriminant analysis Effect Size (LEfSe) confirmed differential taxa (LDA > 3.0), while functional prediction based on PICRUSt2 indicated significant enrichments methane metabolism/cofactor biosynthesis in fatty acid synthesis pathways pMajR. These findings suggest that effectiveness may be influenced differences their metabolites.This highlights prognostic potential predicting HCC.

Language: Английский

Citations

0
Role of the intratumoral microbiome in tumor progression and therapeutics implications DOI

Yufan Meng,

Zhiyao Fan, Bin Zhou

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 189014 - 189014

Published: Nov. 1, 2023

Language: Английский

Citations

9