Optimal cut-off values for anthropometric measures of obesity in screening for cardiometabolic disorders in adults

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: July 9, 2020

Abstract Excessive accumulation of body fat (BF) promotes obesity, whilst posing a significant health hazard. There being no agreed, optimal quantifying methods, application BF variable in clinical practice is not deemed an effective assessment option. The study, involving 4,735 patients (33.6% men), aged 45–64, aimed to identify cut-off values for anthropometric indicators obesity evaluate cardiometabolic risk. A minimum P -value approach was applied calculate the cut-offs BF%. Threshold mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height (WHTR) ratio, facilitating differentiation risk, were based on BF%, expressed as binary classifier. newly estimated predicting BMI, lower than referential thresholds, whereas threshold WC, WHR, WHTR higher. Apart from dyslipidemia, odds disorders higher, when under study exceeded points both sexes. proposed proved instrumental highlighting diagnostic potential BMI boasted highest predictive potential. Cardiometabolic risk also significantly higher even overweight patients.

Language: Английский

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Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in Korean adults

Diabetes/Metabolism Research and Reviews, Journal Year: 2020, Volume and Issue: 37(1)

Published: June 10, 2020

Heart failure with preserved ejection fraction is an emerging global health issue attributed to ageing population. However, the association between low skeletal muscle mass, sarcopenic obesity, and left ventricular diastolic dysfunction remains unclear. In current study, we aimed investigate relationship in a large cohort of Korean adults.We conducted cross-sectional study 31 258 subjects who underwent examinations at Samsung Medical Centre's Health Promotion Centre Seoul, Republic Korea. Relative mass was calculated using index [SMI (%) = appendicular (kg)/body weight (kg) × 100], which estimated by bioelectrical impedance analysis. Cardiac structure function were evaluated echocardiography.Amongst subjects, 3058 (9.78%) determined have dysfunction. The odds ratio (OR) 1.56 [95% confidence interval (CI): 1.31-1.85; p for trend <0.001] lowest SMI tertile relative highest following multivariable adjustment. Furthermore, risk much higher obesity (OR: 1.70, 95% CI: 1.44-1.99), followed obesity-only 1.40, 1.21-1.62), sarcopenia-only 1.32, 1.08-1.61) when compared nonobese, nonsarcopenic group. These results remained consistent amongst elderly (age ≥ 65 years).Our findings demonstrate that lower are strongly associated middle-aged older adults.

Language: Английский

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Circulating branched‐chain amino acids and incident heart failure in type 2 diabetes: The Hong Kong Diabetes Register

Diabetes/Metabolism Research and Reviews, Journal Year: 2020, Volume and Issue: 36(3)

Published: Jan. 19, 2020

Aim Levels of branched‐chain amino acids (BCAAs, namely, isoleucine, leucine, and valine) are modulated by dietary intake metabolic/genetic factors. BCAAs associated with insulin resistance increased risk type 2 diabetes (T2D). Although predicts heart failure (HF), the relationship between HF in T2D remains unknown. Methods In this prospective observational study, we measured fasting serum samples collected at inception from 2139 patients free cardiovascular‐renal diseases. The study outcome was first hospitalization for HF. Results During 29 103 person‐years follow‐up, 115 primary events occurred (age: 54.8 ± 11.2 years, 48.2% men, median [interquartile range] duration: 5 years [1‐10]). Patients incident had 5.6% higher than those without (median 639.3 [561.3‐756.3] vs 605.2 [524.8‐708.7] μmol/L; P = .01). Serum a positive linear association (per‐SD increase logarithmically transformed BCAAs: hazard ratio [HR] 1.22 [95% CI 1.07‐1.39]), adjusting age, sex, duration. HR remained significant after sequential adjustment factors including coronary disease (1.24, 1.09‐1.41); blood pressure, low‐density lipoprotein cholesterol, baseline use related medications (1.31, 1.14‐1.50); HbA 1c , waist circumference, triglyceride, (1.28, 1.11‐1.48); albuminuria estimated glomerular filtration rate 1.11‐1.48). competing death analyses showed similar results. Conclusions Circulating levels independently T2D. Prospective cohort analysis randomized trials needed to evaluate long‐term safety efficacy using different interventions optimize these patients.

Language: Английский

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Metabolically healthy obesity increased diabetes incidence in a middle‐aged and elderly Chinese population

Diabetes/Metabolism Research and Reviews, Journal Year: 2019, Volume and Issue: 36(1)

Published: July 10, 2019

Abstract Background We examined the association between metabolically healthy obese (MHO) and diabetes incidence in a middle‐aged elderly population whether differed by presence of nonalcoholic fatty liver disease (NAFLD). Methods 17 801 participants without at study entry (7980 males 9821 females with mean age 63.2 years) derived from Dongfeng‐Tongji cohort (median follow‐up: 4.6 years). Participants were divided into six groups based on BMI (normal weight, overweight, or obese) metabolic health (healthy/unhealthy) defined Adult Treatment Panel III criteria. The MHO was as greater than 28.0 kg/m 2 0 1 four abnormalities (elevated blood pressure, triglyceridaemia, hyperglycaemia, low HDL cholesterol). hazard ratio (HR) 95% confidence interval (CI) for incident Cox proportional regression model. Results During 79 843 person‐years follow‐up, 1453 individuals developed diabetes. Compared normal weight (MH‐NW) individuals, multivariable‐adjusted HRs (95% CI) 1.74 (1.16‐2.59) 2.15 (1.65‐2.81) unhealthy subjects after adjusting age, sex, smoking, alcohol drinking, physical activity, fruit vegetable consumption, family history diabetes, fasting glucose, waist circumference, NAFLD. Among those NAFLD, showed higher (multivariate‐adjusted HR = 2.71, CI: 1.47‐5.00) MH‐NW individuals. Conclusions phenotype associated increased population, did not differ absence

Language: Английский

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Biomarkers in biological fluids in adults with periodontitis and/or obesity: A meta-analysis

Journal of Indian Society of Periodontology, Journal Year: 2020, Volume and Issue: 24(3), P. 191 - 191

Published: Jan. 1, 2020

Obesity and periodontal diseases have been investigated to be interconnected, but the molecular mechanism underlying this association is still not clear. The aim of systematic review assess serum, salivary gingival crevicular fluid (GCF) inflammatory markers (IMs), obesity, periodontitis. Studies that evaluated IM adults according obesity status (O) periodontitis (P) (O+P+; O-P+; O+P-) were screened on several electronic databases grey literature up until February 2019. Risk bias assessment level evidence through Fowkes Fulton scale Grading Recommendations Assessment, Development Evaluation (GRADE). Meta-analyses grouped biological matrix studied (serum/GCF) groups (O+P+ vs. O−P+/O+P+ O+P−). Out 832 studies screened, 21 considered in qualitative synthesis 15 quantitative (meta-analysis). Although included showed mostly “no” or “minor” problems during quality assessment, GRADE indicated very low moderate based question answered. O+P+ exhibited significantly higher serum levels C-reactive protein (CRP), interleukin 6 (IL-6), leptin, tumor necrosis factor-α (TNF-alpha) resistin GCF than O−P+. IL-6 leptin lower adiponectin O+P−. Only information could obtained vaspin, omentin-1, chemerin, IL-10, progranulin, MCP-4, IL-1β, interferon-γ (IFN-γ). periodontitis, together separately, are associated with altered CRP, IL-6, TNF-alpha, adiponectin, resistin. It was possible evaluate between at levels. role recently biomarkers as IFN-γ, which can key points remains further investigated.

Language: Английский

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<p>Assessment of Age-Induced Changes in Body Fat Percentage and BMI Aided by Bayesian Modelling: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults</p>

Clinical Interventions in Aging, Journal Year: 2020, Volume and Issue: Volume 15, P. 2301 - 2311

Published: Dec. 1, 2020

Loss of fat-free mass (FFM) and gain in body fat (BF) are the key disability risk factors, also instrumental perpetuating already existing functional disorders. Obesity construed terms index (BMI) values, view undesirable BF, is a factor for cardio-metabolic Both detrimental processes clearly evidence scope involutionary changes characteristic an aging population, standing one its greatest burdens.The present study aimed to assess composition (BC), conjunction with relationship between BF% BMI, defining overweight obesity status middle-aged older adults, against select indicator variables under study.The involved 4799 individuals (33.7% men), PONS Project participants, aged 43-64 years. was measured aid bioelectrical impedance analysis (BIA) method. Age-induced BC were determined BF%, (FM), FFM, (FMI), (FFMI). The BMI established Bayesian regression models, adjusted gender age.In both genders, increased age at similar annual rate. reduction FFM noted mainly men, which ensured stability. increase women stable affected BMI. Regardless threshold, anticipated (predicted) genders.Monitoring particular importance appreciably better characteristics short- long-term health predictors, as well overall potential developing specifically targeted, effective interventions.

Language: Английский

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Risk factors for sternal wound infection after median sternotomy: A nested case–control study and time‐to‐event analysis

International Wound Journal, Journal Year: 2024, Volume and Issue: 21(7)

Published: July 1, 2024

Abstract Although potential risk factors for sternal wound infection (SWI) have been extensively studied, the onset time of SWI and different superficial deep were rarely reported. This nested case–control study aims to compare contributors between SWI. Consecutive adult patients who underwent cardiac surgery through median sternotomy in a single center from January 2011 2021 constituted cohort. The case group was those developed as defined by CDC controls matched 6:1 per case. Kaplan–Meier analysis, LASSO univariate multivariate Cox regressions performed. A simple nomogram established clinical prediction incidence 1.1% (61 out 5471) our Totally 366 61 cases. 26.2% (16 61) cases 35 days. DSWI had longer latency than SSWI (median 46 days vs. 32 days, p = 0.032). analyses showed time‐to‐SWI with without DM ( 0.0011) or MI 0.0019). Multivariate regression that BMI (HR 1.083, 95% CI: 1.012–1.116, 0.022), 2.041, 1.094–3.805, 0.025) 2.332, 1.193–4.557, 0.013) independent Superficial only associated 1.089, 1.01–1.175, 0.027), while 3.271, 1.036–10.325, 0.043) 1.004, 1.001–1.008, 0.027). an AUC 0.67, good fitness effectiveness shown calibration curve decision analyses. BMI, compared SSWI. fair performance

Language: Английский

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Lycopene Effects on Metabolic Syndrome and Kidney Injury in Rats Fed a High-Fat Diet: An Experimental Study

ACS Omega, Journal Year: 2022, Volume and Issue: 7(35), P. 30930 - 30938

Published: Aug. 22, 2022

The frequency of overweight and obesity is rising globally. These disorders are prevalent health problems. It has a substantial correlation with number issues, including cardiovascular, metabolic, diabetes mellitus disorders. Lycopene (Lyc) an acyclic structural isomer β-carotene powerful antioxidant properties various promising therapeutic effects. In this study, rats fed high-fat diet were examined to determine how lycopene affected metabolic syndrome kidney damage. After being acclimated, divided into 5 groups (n = 8/group) as follows: the first group served control was on normal pelleted (4.25% fat) until end experiment. second (high-fat diet; HFD) (45.5 kcal% composed 24% fat, protein, 41% carbohydrate. third fourth HFD administered at 25 50 mg/kg bodyweight orally every day. fifth (standard drug group) received simvastatin (SVS; 10 daily) for 3 months. Tissue samples from taken determination biochemical parameters, lipid peroxidation (LPO), protein carbonyl (PC), reduced glutathione (GSH), total thiol group, enzymes, namely, superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx), reductase (GR), in addition renal mRNA expression nuclear factor erythroid 2-related 2 (Nrf2), levels inflammatory markers [tumor necrosis alpha (TNF-α), interleukin-1 beta (IL-1β), kappa-light-chain-enhancer activated B cells (NF-κB)], apoptotic (BCL2 Associated X (Bax), B-cell lymphoma (Bcl-2), Bax/Bcl-2 ratio). When compared group's food consumption, body weight, serum glucose, uric acid, creatinine, LPO, PC, TNF-α, IL-1β, Bax, ratio all increased significantly. sample HFD-fed rats, there downregulation Nrf2 along significant reduction enzymatic activity SOD, CAT, GR, GPx. Lyc treatment able successfully reverse HFD-mediated changes group. Consuming lyc helps prevent fat damage positive way.

Language: Английский

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Youth overweight/obesity and its relationship with cardiovascular disease and parental risk factors

Archives of Endocrinology and Metabolism, Journal Year: 2019, Volume and Issue: unknown

Published: July 11, 2019

The prevalence of overweight and obesity is gradually increasing in both developed developing countries. Obesity, for instance, can present multifactorial causes that interact with each other. Among the important factors, parental plays a prominent role onset during childhood teenage years through genetics ambient aspects. This study aims to verify possible existence an association between overweight/obesity schoolchildren cardiovascular risk (CVR) factors their parents.For this purpose, cross-sectional was conducted sample 1,243 children adolescents, aged 7 17. Out total number participants, 563 (45.3%) were boys who selected across 19 schools urban rural areas Santa Cruz do Sul, Rio Grande Sul (Brazil). status evaluated body mass index (BMI). Additionally, self-reference questionnaire employed measure parents' CVR.The results revealed students have higher probability having father hypertension (OR = 1.49; p 0.038) 2.36; 0.002) mother 1.72; 0.016).To conclude, confirms relationship CVR parents.

Language: Английский

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Hypertension, BMI, and cardiovascular and cerebrovascular diseases

Open Medicine, Journal Year: 2021, Volume and Issue: 16(1), P. 149 - 155

Published: Jan. 1, 2021

Abstract Hypertension is associated with body mass index (BMI) and cardiovascular cerebrovascular diseases (CCDs). Whether hypertension modifies the relationship between BMI CCDs still unclear. We examined association tested whether effect measure modification was present by hypertension. identified a population-based sample of 3,942 participants in Shuncheng, Fushun, Liaoning, China. defined as any past use antihypertensive medication or having measured systolic/diastolic blood pressure ≥130/80 mm Hg. calculated from weight height. Data on diagnosed were self-reported validated medical records. used logistic regression models to estimate odds ratios (ORs) 95% confidence intervals (CIs) for associations CCDs. Higher increased (OR = 1.19, CI: 1.07–1.31). This significantly modified ( P interaction <0.001), positive observed among hypertensive individuals 1.28, 1.14–1.42). Age, sex, diabetic status did not modify (all >0.10). Although higher CCDs, mainly limited patients.

Language: Английский

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