Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(16), P. 2815 - 2821
Published: July 11, 2022
Abstract
The
α‐alkylation
of
ketones
utilizing
a
secondary
alcohol
has
been
accomplished
by
an
isolable,
bench‐stable,
inexpensive
nickel
catalyst
affording
high
yields
β,β‐disubstituted
products.
This
report
contributes
in
the
pool
few
scarce
examples
base
metal
discovered
for
this
purpose.
substrate
scope
can
span
wide
range
including
aliphatic,
alicyclic,
and
cyclic
alcohols.
Functionalization
cholesterol
molecule
is
also
possible
following
methodology.
interconvert
between
azo
hydrazo
form
reversible
fashion
to
enable
chemical
transformation.
magnified
image
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(39), P. 7713 - 7745
Published: Jan. 1, 2022
Recent
advances
in
C/N
alkylation
using
alcohols
as
alkylating
reagents
via
hydrogen-shuttle
methodologies:
Borrowing
Hydrogen,
Acceptorless
Dehydrogenative
Coupling,
and
Base-mediated
Hydride
Transfer.
Organometallics,
Journal Year:
2023,
Volume and Issue:
42(14), P. 1803 - 1809
Published: April 11, 2023
A
new
family
of
air-stable
Mn
and
Re
complexes
bearing
bidentate
bis(1,2,3-triazol-5-ylidene)
ligands
with
the
general
formula
[M(bis-triazolylidene)(CO)3X]
(M
=
or
Re;
X
Cl
Br),
containing
a
methylene
linker
direct
link
between
two
triazolylidene
ligands,
is
presented.
All
have
been
applied
as
catalysts
for
N-alkylation
anilines
benzylic
alcohols.
The
complex
bis-triazolylidene
bridge
fragments
was
shown
to
be
highly
efficient
catalyst,
affording
corresponding
amine
in
92%
yield
presence
low
base
loading
(t-BuOK,
0.1
equiv).
Comparison
imidazolium-
triazolium-derived
N-heterocyclic
carbene
showed
that
triazolylidenes
displayed
higher
catalytic
activity
when
used.
ChemBioChem,
Journal Year:
2023,
Volume and Issue:
24(14)
Published: May 30, 2023
The
application
of
enzymes
in
synthetic
organic
chemistry
has
emerged
as
a
powerful
means
to
generate
molecular
complexity
highly
selective,
efficient,
and
sustainable
manner.
While
have
increasingly
been
incorporated
into
sequences
for
numerous
academic
industrial
applications
on
their
own
sequential
processes,
utility
cooperative
catalysis
with
small
molecule
catalytic
platforms
recently
drawn
increased
attention
across
the
field
synthesis.
In
this
review,
we
present
selection
notable
accomplishments
chemoenzymatic
provide
perspective
its
future
directions.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2142 - 2164
Published: Jan. 17, 2024
Abstract
N‐Heterocyclic
compounds,
in
particular,
quinolines
and
quinazolines
are
frequently
used
medicinal
chemistry.
Therefore,
the
direct
clean
synthesis
of
these
valuable
scaffolds
has
been
a
great
interest
for
many
years.
2‐Aminobenzyl
alcohols
as
an
alternative
reactant
instead
unstable
expensive
2‐aminobenzaldehydes
can
be
construction
N‐fused
heterocycles
including
quinolines,
quinazolines,
oxazines,
thiazines,
selenazines,
imidazoles,
diazepines,
etc.
In
this
review
article,
we
have
discussed
recent
developments
use
2‐aminobenzyl
diverse
heterocycles.
Catalysis Science & Technology,
Journal Year:
2022,
Volume and Issue:
12(10), P. 3202 - 3208
Published: Jan. 1, 2022
The
synthesis
of
N-heterocycles
has
been
considered
an
emerging
topic
chemical
research
due
to
its
widespread
usage
in
medicinal
chemistry,
materials
science,
and
natural
product
synthesis.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(4), P. 2494 - 2504
Published: Feb. 7, 2024
We
report
the
atom-economic
and
sustainable
synthesis
of
biologically
important
3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide
(DHBD)
derivatives
from
readily
available
aromatic
primary
alcohols
2-aminobenzenesulfonamide
catalyzed
by
nickel(II)-N∧N∧S
pincer-type
complexes.
The
synthesized
nickel
complexes
have
been
well-studied
elemental
spectroscopic
(FT-IR,
NMR,
HRMS)
analyses.
solid-state
molecular
structure
complex
2
has
authenticated
a
single-crystal
X-ray
diffraction
study.
Furthermore,
series
(24
examples)
utilizing
3
mol
%
Ni(II)
catalyst
through
acceptorless
dehydrogenative
coupling
benzyl
with
benzenesulfonamide.
Gratifyingly,
catalytic
protocol
is
highly
selective
yield
up
to
93%
produces
eco-friendly
water/hydrogen
gas
as
byproducts.
control
experiments
plausible
mechanistic
investigations
indicate
that
in
situ
generated
aldehyde
benzenesulfonamide
leads
desired
product.
In
addition,
large-scale
one
thiadiazine
unveils
synthetic
usefulness
current
methodology.
