Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications DOI Open Access
Reagan L. Mohlala, Thompho Jason Rashamuse,

E. Mabel Coyanis

et al.

Published: June 5, 2023

Multicomponent reactions (MCRs) have been used for more than a century; since their discovery in 1850 by Strecker. To date, MCRs route is regarded as beneficial strategy due to its capacity quickly produce molecular diversity and structural complexity of interest variety applications. Despite having famous MRCs such the Ugi, Passerini, Biginelli, Hantzsch, this re-view portrays importance synthesis desired products towards applications medicinal purposes, sustainable chemistry, polymerisation. provide ad-vantages reducing number sequential multiple one step, atom economy, recyclable catalysts, mild conditions, preventing waste reduce solvent use.

Language: Английский

Highlighting multicomponent reactions as an efficient and facile alternative route in the chemical synthesis of organic-based molecules: a tremendous growth in the past 5 years DOI Creative Commons
Reagan L. Mohlala, Thompho Jason Rashamuse,

E. Mabel Coyanis

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 18, 2024

Since Strecker’s discovery of multicomponent reactions (MCRs) in 1850, the strategy applying an MCR approach has been use for over a century. Due to their ability quickly develop molecular diversity and structural complexity interest, MCRs are considered efficient organic synthesis. Although such as Ugi, Passerini, Biginelli, Hantzsch widely studied, this review emphasizes significance selective elegantly produce compounds potential medicinal chemistry industrial material science applications, well sustainable methods. During synthesis, provide advantages atom economy, recyclable catalysts, moderate conditions, preventing waste, avoiding solvent use. also reduce number sequential multiple one step.

Language: Английский

Citations

4
The literature of heterocyclic chemistry, part XXII, 2022 DOI
Галина А. Газиева, Yu. B. Evdokimenkova, N. O. Soboleva

et al.

Advances in heterocyclic chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Recent trends for chemoselectivity modulation in one-pot organic transformations DOI Creative Commons

Hiren R. Chaudhary,

Divyang M. Patel

RSC Advances, Journal Year: 2024, Volume and Issue: 14(42), P. 31072 - 31116

Published: Jan. 1, 2024

This article describes recent advances in one-pot chemoselective reactions and their mechanism insights. Here, the substrate, catalyst, solvent, temperature play a vital role modulating chemoselectivity.

Language: Английский

Citations

3
Synthesis and characterization of novel biheterocyclic compounds from 3‐alkoxy‐1H‐pyrazole‐4‐carbaldehydes via multicomponent reactions DOI

Viktorija Savickienė,

Aurimas Bieliauskas, Sergey Belyakov

et al.

Journal of Heterocyclic Chemistry, Journal Year: 2024, Volume and Issue: 61(6), P. 927 - 947

Published: March 27, 2024

Abstract Several series of novel biheterocyclic compounds have been synthesized starting from 3‐alkoxy‐1 H ‐pyrazole‐4‐carbaldehydes and employing different types multicomponent reactions. The structures the obtained 4‐(pyrazol‐4‐yl)pyrano[2,3‐ c ]pyrazole, 4‐(pyrazol‐4‐yl)pyrazolo[4′,3′:5,6]pyrano[2,3‐ b ]quinoline, 4‐(pyrazol‐4‐yl)pyridine, 4‐[(pyrazol‐4‐yl)methylidene]‐1,2‐oxazole derivatives were thoroughly characterized confirmed using detailed nuclear magnetic resonance spectroscopy (NMR), high‐resolution mass spectrometry (HRMS), infrared (IR), X‐ray analysis.

Language: Английский

Citations

2
Bifurcated Rhodaelectro-catalyzed C–H Activation for the Synthesis of Pyrroles and Lactones DOI Creative Commons
Simon L. Homölle, Maximilian Stangier, Efraím Reyes

et al.

Precision Chemistry, Journal Year: 2023, Volume and Issue: 1(6), P. 382 - 387

Published: July 20, 2023

While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly heteroaromatic motives, electrochemical C(sp2)-H activations alkenes remain scarce. Herein, rhodaelectro-catalyzed functionalization enamides is presented efficient construction pyrroles using electricity as sustainable oxidant. Moreover, tuning solvent system allowed fascinating switch in chemoselectivity, which not possible with traditionally used chemical oxidants, giving rise to lactone architectures. The rhoda-electrocatalysis features broad scope well high regio- and chemoselectivities.

Language: Английский

Citations

6
Multicomponent Reactions as an Efficient and Facile Alternative Route in Organic Synthesis and Applications DOI Open Access
Reagan L. Mohlala, Thompho Jason Rashamuse,

E. Mabel Coyanis

et al.

Published: June 5, 2023

Multicomponent reactions (MCRs) have been used for more than a century; since their discovery in 1850 by Strecker. To date, MCRs route is regarded as beneficial strategy due to its capacity quickly produce molecular diversity and structural complexity of interest variety applications. Despite having famous MRCs such the Ugi, Passerini, Biginelli, Hantzsch, this re-view portrays importance synthesis desired products towards applications medicinal purposes, sustainable chemistry, polymerisation. provide ad-vantages reducing number sequential multiple one step, atom economy, recyclable catalysts, mild conditions, preventing waste reduce solvent use.

Language: Английский

Citations

2