Comprehensive Review on the Synthesis of [1,2,3]Triazolo[1,5‐a]Quinolines DOI Open Access
Gabriel P. Costa, Manoela Sacramento, Angelita M. Barcellos

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: 24(11)

Published: Oct. 16, 2024

Abstract This report outlines the evolution and recent progress about different protocols to synthesize N ‐heterocycles fused hybrids, specifically [1,2,3]triazolo[1,5‐ a ]quinoline. review encompasses broad range of approaches, describing several reactions for obtaining this since, such as dehydrogenative cyclization, oxidative − coupling, Dieckmann condensation, intramolecular Heck, (3+2)‐cycloaddition, Ullman‐type coupling direct arylation reactions. We divided in three section based starting materials target ]quinolines. Starting containing quinoline or triazole units previously formed, well which both are formed situ. Different methods described, metal‐free catalyzed conditions, azide‐free, using conventional heating alternative energy sources, electrochemical photochemical methods. Mechanistic insights underlying reported were also described comprehensive review.

Language: Английский

Organocatalytic Synthesis and DNA Interactive Studies of New 1,2,3‐triazolyl‐thiazolidines Hybrids DOI

Allya Larroza,

Liane K. Soares,

Roberto B. Morais

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: 25(7)

Published: Feb. 10, 2024

Abstract An organocatalytic [3+2] cycloaddition reaction between thiazolidine‐containing β ‐ketoester 1 and aryl azides 2 was employed to synthesize new 1,2,3‐triazolyl‐thiazolidine hybrids 3 . In this metal‐free approach, twelve compounds were isolated in yields ranging from 23 % 96 by using diethylamine (10 mol%) DMSO at 75 °C for 24 hours. DNA‐binding assays conducted through absorption, emission spectroscopy viscosimetry analysis, evaluate the interaction capacity of studied derivatives with nucleic acids. All synthesized evaluated their interactions a specific group containing pharmacophoric groups triazole thiazolidine molecular docking speculative study, aimed identifying profile these DNA. The obtained results suggest that could be promising approach development novel therapeutic agents targeting DNA‐related processes.

Language: Английский

Citations

2
Organocatalyzed 1,2,3-Triazoles Forming Click Chemistry DOI
Vinod K. Tiwari, Manoj K. Jaiswal, Sanchayita Rajkhowa

et al.

Materials horizons, Journal Year: 2024, Volume and Issue: unknown, P. 113 - 144

Published: Jan. 1, 2024

Language: Английский

Citations

0
Comprehensive Review on the Synthesis of [1,2,3]Triazolo[1,5‐a]Quinolines DOI Open Access
Gabriel P. Costa, Manoela Sacramento, Angelita M. Barcellos

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: 24(11)

Published: Oct. 16, 2024

Abstract This report outlines the evolution and recent progress about different protocols to synthesize N ‐heterocycles fused hybrids, specifically [1,2,3]triazolo[1,5‐ a ]quinoline. review encompasses broad range of approaches, describing several reactions for obtaining this since, such as dehydrogenative cyclization, oxidative − coupling, Dieckmann condensation, intramolecular Heck, (3+2)‐cycloaddition, Ullman‐type coupling direct arylation reactions. We divided in three section based starting materials target ]quinolines. Starting containing quinoline or triazole units previously formed, well which both are formed situ. Different methods described, metal‐free catalyzed conditions, azide‐free, using conventional heating alternative energy sources, electrochemical photochemical methods. Mechanistic insights underlying reported were also described comprehensive review.

Language: Английский

Citations

0