The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
N-Sulfonyl
hydrazones
have
been
extensively
used
as
operationally
safe
carbene
precursors
in
modern
organic
synthesis
due
to
their
ready
availability,
facile
functionalization,
and
environmental
benignity.
Over
the
past
two
decades,
there
has
tremendous
progress
chemistry
of
N-sulfonyl
presence
transition
metal
catalysts,
under
metal-free
conditions,
or
using
photocatalysts
photoirradiation
conditions.
Many
transfer
reactions
are
unique
cannot
be
achieved
by
any
alternative
methods.
The
discovery
novel
development
highly
enantioselective
new
skeletal
editing
represent
notable
recent
achievements
hydrazones.
This
review
describes
overall
made
hydrazones,
organized
based
on
reaction
types,
spotlighting
current
state-of-the-art
remaining
challenges
addressed
future.
Special
emphasis
is
devoted
identifying,
describing,
comparing
scope
limitations
methodologies,
key
mechanistic
scenarios,
potential
applications
complex
molecules.
Language: Английский
Catalytic Asymmetric Approach to the Naturally Occurring Clavine Alkaloid, (+)-Lysergine
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 13, 2024
Abstract
An
efficient
asymmetric
approach
to
the
ergot
alkaloids
has
been
achieved
via
a
highly
regioselective
Heck
cyclization.
Asymmetric
induction
of
key
intermediate
was
catalytic
enantioselective
α-aminoxylation
catalyzed
by
d-proline
(98%
ee).
Utilizing
aforementioned
strategy,
formal
total
synthesis
(+)-lysergine
and
(+)-isolysergine
achieved.
Importantly,
an
unnatural
analogues
(–)-lysergine
(–)-isolysergine
also
using
l-proline.
Language: Английский