Gender Differences in Dendritic Damage, Gut Microbiota Dysbiosis, and Cognitive Impairment During Aging Processes DOI Creative Commons

Ying-Ying Han,

Kang Li, Jian Hu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(12)

Published: Dec. 1, 2024

ABSTRACT Background Cognitive impairment is a common and feared characteristic of aging processes, one key mechanism cognition hippocampal synaptic structure. Previous studies have reported that gut microbiota dysbiosis occurred in neurodegenerative diseases other brain disorders with cognitive impairment. However, it not clear how gender differences affect processes whether they structure microbiota. Here, we studied the ability, dendritic morphology, adult, middle‐, old‐aged rats. Methods The ability rats using was assessed by Y‐maze SAB test, light/dark discrimination MWM test. Dendritic morphology investegated Golgi staining. Microbiota composition, diversity richness were analyzed 16S rRNA gene sequencing. Results results showed decreased than adult middle‐aged spontaneous alternation behavior test Y‐maze, test; males better females for neuronal structures CA1, CA3, DG regions hippocampus damaged to different degrees during aging, spine loss more CA1 CA3 In addition, microbial significantly male rats; distribution composition communities between female at ages. Conclusion These findings revealed aged might result from damage dysbiosis, which provides direct evidence associate naturally

Language: Английский

Stilbenes, a Versatile Class of Natural Metabolites for Inflammation—An Overview DOI Creative Commons
Jameel M. Al-Khayri, Roseanne Mascarenhas,

Himanshu Madapur Harish

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3786 - 3786

Published: April 28, 2023

Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They now exploited in medicine for their antioxidant, anti-proliferative and anti-inflammatory properties. Inflammation is the immune system's response invading bacteria, toxic chemicals or even nutrient-deprived It characterized release of cytokines which can wreak havoc on healthy tissues, worsening disease condition. modulate NF-κB, MAPK JAK/STAT pathways, reduce transcription inflammatory factors result maintenance homeostatic Resveratrol, most studied stilbene, lowers Michaelis constant SIRT1, occupies substrate binding pocket. Gigantol interferes with complement system. Besides these, oxyresveratrol, pterostilbene, polydatin, viniferins, front runners as drug candidates due diverse effects from different functional groups that affect bioavailability molecular interactions. However, they each have thresholds toxicity various cells human body, thus a careful review properties must be conducted. In animal models autoinflammatory diseases, mode application stilbenes important absorption curative effects, seen topical microemulsion gel methods. This covers diversity among plant kingdom mechanism action pathways. detail, macrophages' contribution inflamed conditions liver, cardiac, connective neural nephrons, intestine, lungs myriad other body explored, along detailed explanation how alleviate symptoms specific site. A section included understanding limitations natural compounds directly used drugs rapid metabolism. Current delivery mechanisms include sulphonamides, using specially designed synthetic drugs. hoped further research may fueled this comprehensive work makes compelling argument exploitation these medicine.

Language: Английский

Citations

36
Pterostilbene in the treatment of inflammatory and oncological diseases DOI Creative Commons
Peijun Liu, Weihua Tang,

Kali Xiang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Pterostilbene (PTS), a naturally occurring analog of resveratrol (RSV), has garnered significant attention due to its potential therapeutic effects in treating inflammatory and oncological diseases. This comprehensive review elucidates the pharmacological properties, mechanisms action, PTS. Various studies indicate that PTS exhibits anti-inflammatory, antioxidant, antitumour potentially making it promising candidate for clinical applications. Its influence on regulatory pathways like NF-κB PI3K/Akt underscores diverse strategies addressing Additionally, showcases favorable pharmacokinetic profile with better oral bioavailability compared other stilbenoids, thus enhancing potential. Given these findings, there is an increased interest incorporating into treatment regimens cancer-related conditions. However, more extensive trials are imperative establish safety efficacy patient populations.

Language: Английский

Citations

14
Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis DOI Creative Commons

Yue Tian,

Guangchan Jing,

Mei Ma

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 165, P. 105848 - 105848

Published: Aug. 13, 2024

Microglia, as immune cells in the central nervous system, are closely related to cognitive impairment associated with type 2 diabetes (T2D). Preliminary explorations have investigated relationship between T2D-related and activation polarization of microglia. This review summarizes potential mechanisms microglial context T2D. It discusses inflammatory responses, neuronal apoptosis, amyloid-β deposition, abnormal phosphorylation Tau protein mediated by polarization, exploring connections from multiple perspectives. Additionally, this provides references for future treatment targeting microglia clinical translation.

Language: Английский

Citations

9
Gut Metabolites Acting on the Gut-Brain Axis: Regulating the Functional State of Microglia DOI Creative Commons

Wenze Deng,

Pengcheng Yi, Yanhong Xiong

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: 15(2), P. 480 - 480

Published: Aug. 3, 2023

The gut-brain axis is a communication channel that mediates complex interplay of intestinal flora with the neural, endocrine, and immune systems, linking gut brain functions. Gut metabolites, group small molecules produced or consumed by biochemical processes in gut, are involved central nervous system regulation via highly interconnected affecting microglia indirectly influencing structure directly function activity. Accordingly, pathological changes connected metabolite levels as well altered activity, which may contribute to process each neuroinflammatory condition. Here, we discuss mechanisms for instance, bile acids, short-chain fatty tryptophan regulate component axis, explore important roles metabolites from perspective microglia. At same time, highlight pathogenesis neurodegenerative diseases neurodevelopmental disorders. Understanding relationship between microglia, microbiota, neuroinflammation, disorders will help us identify new strategies treating neuropsychiatric

Language: Английский

Citations

11
Research progress on the association of insulin resistance with type 2 diabetes mellitus and Alzheimer’s disease DOI
Miao Zheng, Can Wang, Min Hu

et al.

Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 40(1)

Published: Nov. 21, 2024

Language: Английский

Citations

4
Unlocking Gut Health: The Potent Role of Stilbenoids in Intestinal Homeostasis DOI Creative Commons
Tiantian Meng,

Ziwei Wen,

Xiaofang Cheng

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 417 - 417

Published: Feb. 3, 2025

Stilbenoids are a class of naturally occurring phenolic compounds found in various plant species, characterized by stilbene backbone with diverse substituents that confer range biological activities. These exhibit antioxidant, anti-inflammatory, and antimicrobial properties, making them promising candidates for improving intestinal health. The tract plays critical role nutrient digestion, absorption, immune defense, maintaining its integrity is vital animal growth. contribute to gut health enhancing morphology, supporting mucosal responses, regulating microbiota composition, modulating metabolic pathways, mitochondrial This review provides comprehensive analysis key stilbenoids, including resveratrol, pterostilbene, piceatannol, oxyresveratrol, focusing on their effects regulatory mechanisms. By highlighting roles mitigating inflammation promoting function, this basis the practical application stilbenoids husbandry.

Language: Английский

Citations

0
Reshaping the Gut Microbiota: Tangliping Decoction and Its Core Blood-Absorbed Component Quercetin Improve Diabetic Cognitive Impairment DOI

Wenlan Zhang,

Chunmei Yi,

Zhijie Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156560 - 156560

Published: March 5, 2025

Language: Английский

Citations

0
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications DOI Creative Commons
Rengasamy Balakrishnan, Seungha Kang, Ji Yeon Lee

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

The human body contains approximately 100 trillion microorganisms, predominantly within the gastrointestinal tract, collectively called gut microbiota. Investigations have revealed bidirectional communication between microbiota and brain, characterized as "microbiota-gut-brain axis." This axis represents an important regulator of brain development function, immune system development, nutrient metabolism, making it a target for efforts to alleviate progression neurodegenerative diseases (NDDs). Despite extensive biomedical clinical research, our understanding causes, optimal treatment, NDDs remains limited. paper aims summarize available knowledge on role played by how is connected conditions; in particular, relationship gut-brain communications neuro-immune conditions reviewed. We discuss why communicates with this impacts neurodegeneration. Next, we examine alterations microbiota, response, changes associated dysbiosis. Finally, highlight preclinical evidence probiotics, prebiotics, fecal transplantation, dietary supplements, natural drugs, exercise intervention potential therapeutic approaches that could lead new treatment paradigm NDDs.

Language: Английский

Citations

3
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling DOI
Zhi‐Tong Zhang, Qingfeng Liang, Handong Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 323, P. 117647 - 117647

Published: Dec. 30, 2023

Language: Английский

Citations

7
Diabetes and vascular mild cognitive impairment among Chinese ≥50 years: A cross‐sectional study with 2020 participants DOI Creative Commons
Yu Zhang,

Wenna Liu,

Chen Fu

et al.

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(5)

Published: April 28, 2024

Abstract Background With the decline of cognitive function in vascular impairment, burden on family and society will increase. Therefore, early identification mild impairment (VaMCI) is crucial. The focus VaMCI attention risk factors. this study aimed to investigate relationship between diabetes among Chinese, hoping predict by move forward. Methods We collected data from seven clinical centers nine communities China. All participants were over 50 years age had complaints. basic information participants, was professionally assessed Montreal Cognitive Assessment scale. Finally, logistic regression analysis used analyze correlation each factor VaMCI. Results A total 2020 included, including 1140 with 880 normal cognition. In univariate analysis, age, heavy smoking, a positive At same time, being married, high education, light smoking negative After correction, only (OR = 1.04, 95% CI: 1.01–1.09, p 0.05) VaMCI, education 0.60, CI:.45–.81, 0.001) Conclusion our study, we found that timely intervention may reduce achieve prevention

Language: Английский

Citations

2