Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(38), P. 9686 - 9694
Published: Jan. 1, 2024
A dual-sensitizing ABMN nanocomposite was designed and developed to improve the sensitivity of radiotherapy tumor cells promote efficacy cell killing by exploiting microenvironment's oxygen deficiency.
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1289 - 1324
Published: Jan. 2, 2024
A significant amount of progress in nanotechnology has been made due to the development engineered nanoparticles. The use metallic nanoparticles for various biomedical applications extensively investigated. Biomedical research is highly focused on them because their inert nature, nanoscale structure, and similar size many biological molecules. intrinsic characteristics these particles, including electronic, optical, physicochemical, surface plasmon resonance, that can be altered by altering size, shape, environment, aspect ratio, ease synthesis, functionalization properties, have led numerous applications. Targeted drug delivery, sensing, photothermal photodynamic therapy, imaging are some these. promising clinical results NBTXR3, a high-Z radiosensitizing nanomaterial derived from hafnium, demonstrated translational potential this metal. This radiosensitization approach leverages dependence energy attenuation atomic number enhance energy-matter interactions conducive radiation therapy. High-Z nanoparticle localization tumor issue differentially increases effect ionizing cancer cells versus nearby healthy ones mitigates adverse effects reducing overall burden. principle enables material multifunctionality as contrast agents X-ray-based imaging. physiochemical properties hafnium (Z = 72) particularly advantageous well-placed K-edge absorption high mass coefficient compared elements human tissue across ranges leads attenuation. Chemical reactivity allows variety composition, functionalization. Nanoparticles such oxide exhibit excellent biocompatibility inertness prior incidence with radiation. Additionally, optical electronic applicable biosensing, component coatings, semiconductors. wide interest prompted extensive design synthesis facilitate property fine-tuning. review summarizes synthetic methods hafnium-based nanomaterials imaging, biosensing mechanistic focus. discussion future perspective section highlights elaborates current challenges. By focusing factors impacting applicational effectiveness examining limitations aims support researchers expedite translation nanomedicine.
Language: Английский
Citations
19
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 1, 2024
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.
Language: Английский
Citations
18
Small, Journal Year: 2024, Volume and Issue: 20(32)
Published: March 20, 2024
Abstract The combination of ferroptosis and innovative tumor therapy methods offers another promising answer to the problem tumors. In order generate effective in cells, iron‐based nanomaterials are commonly utilized introduce foreign iron as a trigger for ferroptosis. However, this usually necessitates injection larger doses into body. These exogenous increases likely create concealed concerns symptoms such liver damage allergy. Herein, an iron‐free radiosensitizer is introduced, oxygen‐vacancy‐rich MnO 2 nanoflowers ( ovs ‐MnO ), that promotes modifies microenvironment assist radiotherapy. with enriched oxygen vacancies on surface induces release intracellular free (Fe 2+ which functions activator Fenton reaction enhances accumulation reactive species. On other hand, Fe also triggers lipid peroxides. Subsequently, depletion glutathione peroxidation cells leads inactivation peroxidase 4 (GPX4) ferroptosis, thereby enhancing therapeutic efficacy nanoplatform provides novel strategy generating nanomedicines ferroptosis‐assisted
Language: Английский
Citations
11
ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2485 - 2499
Published: Jan. 10, 2024
Addressing the critical requirement for real-time monitoring of tumor progression in cancer care, this study introduces an innovative wearable platform. This platform employs a thermoplastic polyurethane (TPU) film embedded with hafnium oxide nanoparticles (HfO2 NPs) to facilitate dynamic tracking growth and regression real time. Significantly, synthesized HfO2 NPs exhibit promising characteristics as effective sonosensitizers, holding potential efficiently eliminate cells through ultrasound irradiation. The TPU-HfO2 film, acting dielectric elastomer (DE) strain sensor, undergoes proportional deformation response changes volume, thereby influencing its electrical impedance. distinctive behavior empowers DE sensor continuously accurately monitor alterations determining optimal timing initiating NP treatment, optimizing dosages, assessing treatment effectiveness. Seamless integration wireless system allows instant transmission detected impedances smartphone data processing visualization, enabling immediate patient timely intervention by remote medical staff. By combining capabilities sonosensitizer NPs, approach propels care into realm telemedicine, representing significant advancement treatment.
Language: Английский
Citations
10
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 153086 - 153086
Published: June 13, 2024
Language: Английский
Citations
9
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 21, 2024
Recently, there has been significant interest in nanoscale metal-organic frameworks (NMOFs) characterized by ordered crystal structures and coordination polymers (NCPs) featuring amorphous structures. These arise from the interactions between inorganic metal ions or clusters organic ligands. Their advantages, such as ability to tailor composition structure, efficiently encapsulate diverse therapeutic imaging agents within porous frameworks, inherent biodegradability, surface functionalization capability, position them promising carriers biomedical fields. This review provides an overview of synthesis modification strategies employed for NMOFs NCPs, along with their applications cancer treatment biological imaging. Finally, future directions challenges associated utilization NCPs diagnosis are also discussed.
Language: Английский
Citations
8
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 9, 2024
Abstract Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO 2 ) that was core coated with MnO shell followed by glucose oxidase (GOx) doping nanoplatform @MnO @GOx, HMG) to trigger ferroptosis adjuvant effects glutathione depletion and reactive oxygen species production. This cascade potentiation further sensitized radiotherapy enhancing DNA damage in 4T1 breast tumor cells. The combination of HMG nanoparticles effectively activated the damaged Mn 2+ -mediated cGAS-STING pathway vitro vivo. process had significant inhibitory on progression initiating an anticancer systemic response prevent distant recurrence achieve long-lasting suppression both primary tumors. Furthermore, as-prepared “turned on” spectral computed tomography (CT)/magnetic resonance dual-modality imaging signals, demonstrated favorable contrast enhancement capabilities under GSH microenvironment. result highlighted potential as theranostic achieving molecular guided sensitization induced synergistic immunotherapy.
Language: Английский
Citations
7
Medical Review, Journal Year: 2024, Volume and Issue: 4(1), P. 5 - 30
Published: Feb. 1, 2024
Abstract Cancer nanomedicine is defined as the application of nanotechnology and nanomaterials for formulation cancer therapeutics that can overcome impediments restrictions traditional chemotherapeutics. Multidrug resistance (MDR) in cells be a decrease or abrogation efficacy anticancer drugs have different molecular structures mechanisms action one primary causes therapeutic failure. There been successes development to MDR; however, relatively few these formulations approved by United States Food Drug Administration treatment cancer. This primarily due paucity knowledge about fundamental biology cells. Here, we discuss advances, types nanomedicines, challenges regarding translation vitro vivo results their relevance effective therapies.
Language: Английский
Citations
6
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1306, P. 137842 - 137842
Published: Feb. 20, 2024
Language: Английский
Citations
6
ChemSusChem, Journal Year: 2024, Volume and Issue: unknown
Published: April 26, 2024
Metal-organic frameworks (MOFs) are robust, crystalline, and porous materials featured by their superior CO
Language: Английский
Citations
6