Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ T cells for triple-negative breast cancer therapy DOI Creative Commons
Ting Yang, Zihan Liu,

Zixuan Fu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 100970 - 100970

Published: Oct. 1, 2024

Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, ferroptosis accompanied with down-regulation glutathione peroxidase 4 (GPX4) lead to CD36-mediated tumor-infiltrating CD8+ T cells uptaking fatty acids, negative action on immunotherapeutic efficacy. Herein, albumin nanoparticles, abbreviated LHS NPs, were designed by co-assembly hemin, linoleic acid-cystamine, CD36 inhibitor sulfosuccinimide oleate, bi-directionally manipulated tumor TNBC NPs exerted more efficient reactive oxygen species generation, depletion malondialdehyde production combinatory classical non-classical modes, which amplified positive cells. Meanwhile, inhibiting mediated-lipid cells, thereby activating efficacy improvements induction immunogenic death, proliferation CD4+CD8+ natural killer alleviation immunosuppressive regulatory myeloid-derived suppressor repolarization M2- M1-phenotype tumor-associated macrophages. Thus, demonstrated an improved antitumor suppressing growth lung metastasis 4T1-tumor mice. Our work gives novel insights manipulating chemoimmunotherapy.

Language: Английский

Cuproptosis: unveiling a new frontier in cancer biology and therapeutics DOI Creative Commons

Ying Feng,

Zhibo Yang,

Jianpeng Wang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 1, 2024

Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known death mechanisms. This process involves the interaction copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation death. Recently, growing number studies have explored link between cuproptosis cancer development. review comprehensively examines systemic metabolism copper, including tumor-related signaling pathways influenced by copper. It delves into discovery mechanisms connection various cancers. Additionally, suggests potential treatments using ionophores that induce combination small molecule drugs, for precision therapy specific types.

Language: Английский

Citations

19
Ferroptosis-Related Oxaliplatin Resistance in Multiple Cancers: Potential Roles and Therapeutic Implications DOI Creative Commons

Si-Jia Zhong,

Zihan Wang,

Jiaxi Yang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37613 - e37613

Published: Sept. 1, 2024

Oxaliplatin (OXA)-based therapy is effective in the treatment of multiple cancers. However, primary or acquired OXA resistance remains an emerging challenge for its clinical application. Ferroptosis iron-dependent mode cell death that has been demonstrated to play essential role chemoresistance many drugs, including OXA. In particular, dysregulation SLC7A11-GPX4, one major antioxidant systems ferroptosis, was found colorectal cancer (CRC) and hepatocellular carcinoma (HCC). addition, Nrf2, upstream regulator GPX4 other factors, also involved CRC HCC. Inhibition SLC7A11-GPX4 Nrf2 by genetic deletion pharmaceutical inhibition could significantly reverse resistance. Long noncoding RNA (lncRNA) participates ferroptosis cells. Specifically, LINC01134 promotes recruitment promoter GPX4, thereby exerting transcriptional regulation which eventually increases sensitivity HCC through upregulation ferroptosis. On hand, a novel lncRNA DACT3-AS1 sensitizes gastric cells miR-181a-5p/sirtuin 1(SIRT1)-mediated Therapies based on combination enhancers provide new therapeutic insights overcome present review, we current understanding ferroptosis-related resistance, highlight pathogenesis chemoresistance, summarize available therapies target enhancing

Language: Английский

Citations

5
Ruthenium(ii)–Arene Complex Triggers Immunogenic Ferroptosis for Reversing Drug Resistance DOI

Mengdi Lv,

Yue Zheng,

Xiangyu Dai

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Chemoresistance remains an arduous challenge in oncology, but ferroptosis shows potential for overcoming it by stimulating the immune system. Herein, a novel high-performance ruthenium(II)-based arene complex [Ru(η

Language: Английский

Citations

4
Seeding Janus Zn–Fe Diatomic Pairs on a Hollow Nanobox for Potent Catalytic Therapy DOI
Jin Ye,

Yunlong Li,

Jiating Xu

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Dual atomic nanozymes (DAzymes) are promising for applications in the field of tumor catalytic therapy. Here, integrating with ultrasmall Fe5C2 nanoclusters, asymmetric coordination featuring Janus Zn-Fe dual-atom sites an O2N2-Fe-Zn-N4 moiety embedded a carbon vacancy-engineered hollow nanobox (Janus ZnFe DAs-Fe5C2) was elaborately developed. Theoretical calculation revealed that synergistic effects Zn centers acting as both adsorption and active sites, oxygen-heteroatom doping, vacancy, nanoclusters jointly downshifted d-band center Fe 3d orbitals, optimizing desorption behaviors intermediates *OH, thereby significantly promoting activity. Upon 1064 nm laser irradiation, DAs-Fe5C2 superior photothermal conversion efficiency (η = 62.5%) showed thermal-augmented Fascinatingly, multienzymatic properties can suppress expression glutathione peroxidase 4 accelerate accumulation lipid peroxides, through which ferroptosis is triggered. Overall, tannin-involved will inspire more inventions biodegradable DAzymes therapy application.

Language: Английский

Citations

0
Photo-responsive g-C3N4/copper molybdate nanocomposites enable laser-driven multi-modal imaging, photothermal and chemodynamic therapy for hepatocellular carcinoma treatment DOI

Kayalvizhi Samuvel Muthiah,

Sathan Raj Natarajan,

Selvaraj Jayaraman

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160751 - 160751

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanomedicine with simple structure for programmable heat-shock protein inhibition and sensitized synergistic therapy DOI Creative Commons
Hanji Huang, Yan Sun, Jinhong Cai

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161307 - 161307

Published: March 1, 2025

Language: Английский

Citations

0
Engineered Photoactivatable Nanomicelles for Ferroptosis-like Combinational Tumor Therapy In Vitro and In Vivo DOI
Yandai Lin, Xinru Kong, Zhe Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Nitric oxide (NO)-based gas therapy has attracted increasing attention as a promising approach for tumor treatment, but elevated levels of glutathione (GSH) in the microenvironment significantly limit their therapeutic effectiveness. In this study, type engineered photoactivatable nanomicelles Ce6/NI@PEP@HA (CNPH) were developed combinational photodynamic and NO therapy. CNPH was capable targeted accumulation to tumors, where it depleted GSH released effectively produce reactive oxygen species (ROS) with oxidative damage under laser irradiation at 660 nm. The consumption induced deactivation peroxidase activity, leading enhanced toxic lipid peroxide enabled ferroptosis-like outcome. Additionally, effective production ROS resulted mitochondrial dysfunction, characterized by disruption membrane potential decreased adenosine triphosphate concentration. vivo animal experiments indicated that achieved inhibition 89.1%, proven be more strategy contrast any single modality. consequence, opened up new horizon cutting-edge noninvasive paradigm advanced treatments.

Language: Английский

Citations

0
Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol DOI Creative Commons
Jianwen Li, Shuyue Zhan, Wei Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 26, 2025

Abstract Background Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge. Methods We explore approach that enables induction through external radiation. The key component of this technology 7-dehydrocholesterol (7DHC), natural biosynthetic precursor cholesterol. To facilitate delivery, we demonstrate 7DHC, like cholesterol, can be incorporated into the layer liposomes. enhance targeting, also introduced NTS mut , ligand for neurotensin receptor 1 (NTSR1), which overexpressed multiple malignancies, Results Under radiation, 7DHC reacts with radiation-induced reactive oxygen species (ROS), initiating radical chain reaction polyunsaturated fatty acids (PUFAs) membranes. This process results direct peroxidation and subsequent ferroptotic death. In vivo studies -conjugated, 7DHC-loaded liposomes (N-7DHC-lipos) effectively accumulate tumors significantly efficacy radiation therapy. Conclusion While conventional radiosensitizers primarily target DNA its repair mechanisms, our study introduces strategy to radiotherapy specifically activating within irradiated area, thereby minimizing systemic toxicity. Such controlled activation offers favorable therapeutic index potentially opens avenues clinical application.

Language: Английский

Citations

0
A tandem-unlocked cascade nanoreactor for high-contrast magnetic resonance imaging-guided enhanced ferroptosis-chemo synergistic therapy DOI Creative Commons
Weiping Liu, Alice H. Huang, Tianqi Luo

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101852 - 101852

Published: May 1, 2025

Language: Английский

Citations

0
Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential DOI Open Access

Yu Zhang,

Xiangxiang Zhou

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116667 - 116667

Published: May 3, 2024

Regulated cell death (RCD) is a form of that can be regulated by numerous biomacromolecules. Accumulating evidence suggests dysregulated expression and altered localization related proteins in RCD promote the development cancer. Targeting subroutines with pharmacological small-molecule compounds becoming promising therapeutic avenue for anti-tumor treatment, especially hematological malignancies. Herein, we summarize aberrant mechanisms apoptosis, necroptosis, pyroptosis, PANoptosis, ferroptosis In particular, focus on relationship between tumorigenesis, immunotherapy, drug resistance Furthermore, discuss emerging strategies targeting different subroutines. This review aims to significance potential malignancies, along utilization pertinent strategies.

Language: Английский

Citations

3