Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100970 - 100970
Published: Oct. 1, 2024
Ferroptosis
can
serve
as
a
potent
strategy
for
regulating
cell
death
via
lipid
peroxidation
and
the
imbalance
of
antioxidant
system
resulting
from
iron
accumulation
in
triple-negative
breast
cancer
(TNBC)
therapy.
However,
ferroptosis
accompanied
with
down-regulation
glutathione
peroxidase
4
(GPX4)
lead
to
CD36-mediated
tumor-infiltrating
CD8+
T
cells
uptaking
fatty
acids,
negative
action
on
immunotherapeutic
efficacy.
Herein,
albumin
nanoparticles,
abbreviated
LHS
NPs,
were
designed
by
co-assembly
hemin,
linoleic
acid-cystamine,
CD36
inhibitor
sulfosuccinimide
oleate,
bi-directionally
manipulated
tumor
TNBC
NPs
exerted
more
efficient
reactive
oxygen
species
generation,
depletion
malondialdehyde
production
combinatory
classical
non-classical
modes,
which
amplified
positive
cells.
Meanwhile,
inhibiting
mediated-lipid
cells,
thereby
activating
efficacy
improvements
induction
immunogenic
death,
proliferation
CD4+CD8+
natural
killer
alleviation
immunosuppressive
regulatory
myeloid-derived
suppressor
repolarization
M2-
M1-phenotype
tumor-associated
macrophages.
Thus,
demonstrated
an
improved
antitumor
suppressing
growth
lung
metastasis
4T1-tumor
mice.
Our
work
gives
novel
insights
manipulating
chemoimmunotherapy.
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 30, 2024
Innovative
strategies
for
targeted
anticancer
therapies
have
gained
significant
momentum,
with
metal
complexes
emerging
as
tunable
catalysts
more
effective
and
safer
treatments.
Rational
design
engineering
of
enable
the
development
tailored
molecular
structures
optimized
precision
oncology.
The
strategic
incorporation
complex
within
combinatorial
amplifies
their
properties.
This
perspective
highlights
advancements
in
synthetic
rational
since
2019,
showing
how
are
by
designing
to
release
or
Physica Scripta,
Journal Year:
2024,
Volume and Issue:
99(8), P. 085413 - 085413
Published: July 22, 2024
Abstract
The
[Fe
4
S
]
compositions
are
ubiquitous
in
biological
systems
as
integral
parts
of
the
complex
catalytic
mechanisms
hydrogenases
and
nitrogenases.
current
reports
about
species
based
on
cube-like
structure
framework.
Here,
topological
structures,
stability
electronic
properties
gas
phase
+
,
0
−
analyzed.
It
is
found
that
ground
state
structures
these
three
clusters
have
similar
cubic
cages
but
different
symmetries
spin
multiplicities.
molecular
dynamics
simulations
demonstrate
cage
remains
thermodynamically
stable
at
700
K.
density
states
show
charge
key
to
affect
behaviors
them
even
under
same
structural
orbitals
LUMO
distributed
throughout
whole
showing
great
delocalized
characteristics,
especially
for
anionic
while
HOMO
orbits
mainly
localized
Fe-S
bonds,
which
also
confirmed
by
electron
localization
function
analyses.
After
one
CO
molecule
adsorbed
clusters,
it
prefers
locate
Fe
atoms.
Moreover,
C–O
bond
length
vibration
frequency
-CO
undergone
a
significant
red
shift.
Our
work
shows
may
act
potential
catalyst
activating
bond.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100970 - 100970
Published: Oct. 1, 2024
Ferroptosis
can
serve
as
a
potent
strategy
for
regulating
cell
death
via
lipid
peroxidation
and
the
imbalance
of
antioxidant
system
resulting
from
iron
accumulation
in
triple-negative
breast
cancer
(TNBC)
therapy.
However,
ferroptosis
accompanied
with
down-regulation
glutathione
peroxidase
4
(GPX4)
lead
to
CD36-mediated
tumor-infiltrating
CD8+
T
cells
uptaking
fatty
acids,
negative
action
on
immunotherapeutic
efficacy.
Herein,
albumin
nanoparticles,
abbreviated
LHS
NPs,
were
designed
by
co-assembly
hemin,
linoleic
acid-cystamine,
CD36
inhibitor
sulfosuccinimide
oleate,
bi-directionally
manipulated
tumor
TNBC
NPs
exerted
more
efficient
reactive
oxygen
species
generation,
depletion
malondialdehyde
production
combinatory
classical
non-classical
modes,
which
amplified
positive
cells.
Meanwhile,
inhibiting
mediated-lipid
cells,
thereby
activating
efficacy
improvements
induction
immunogenic
death,
proliferation
CD4+CD8+
natural
killer
alleviation
immunosuppressive
regulatory
myeloid-derived
suppressor
repolarization
M2-
M1-phenotype
tumor-associated
macrophages.
Thus,
demonstrated
an
improved
antitumor
suppressing
growth
lung
metastasis
4T1-tumor
mice.
Our
work
gives
novel
insights
manipulating
chemoimmunotherapy.
