Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(32), P. 7870 - 7878
Published: Jan. 1, 2024
Aiming
to
decrease
the
recurrence
of
tumors
and
achieve
patient
satisfaction,
elicitation
immunotherapy
its
integrated
synergistic
employment
is
a
bright
new
direction
in
oncotherapy,
yet
an
emergently
challenging
task.
In
particular,
tumor-associated
macrophage
(TAM)
regulation
though
light-induced
photodynamic
photothermal
therapy
(PDT
PTT)
regarded
as
powerful
approach,
which
focuses
on
systemic
immune
system
instead
tumor
itself.
Herein,
this
study
reports
acceptor-donor-acceptor
(A-D-A)
aggregation-induced
emission
luminogen
(AIEgen),
named
TPA-2CN,
was
applied
photosensitizer
(PS)
agent
(PTA).
Attributed
A-D-A
structure
AIE
properties,
TPA-2CN
exhibits
high
molar
absorption
coefficient
acts
perfect
template
regulating
radiative
nonradiative
transitions,
mainly
utilize
excited
energy.
The
generation
type
I
reactive
oxygen
promoted
application
hypoxic
sites
combination
hyperpyrexia
forcefully
induces
macrophages
polarize
towards
response
M1
phenotype.
Small,
Journal Year:
2024,
Volume and Issue:
20(47)
Published: Aug. 24, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment,
but
limited
oxygen
supply
in
tumors
(hypoxia)
can
hinder
its
effectiveness.
This
because
traditional
PDT
relies
on
Type‐II
reactions
that
require
oxygen.
Type‐I
photosensitizers
(PSs)
offer
approach
to
overcome
the
limitations
of
tumor
photodynamic
hypoxic
environments.
To
leverage
advantages
PDT,
design
and
evaluation
series
PSs
for
developing
pure
Type‐1
PSs,
by
incorporating
benzene,
thiophene,
or
bithiophene
into
donor–acceptor
molecular
skeleton
are
reported.
Among
them,
CTTI
(with
bithiophene)
shows
best
performance,
generating
most
superoxide
radical
(O
2
•−
)
upon
light
irradiation.
Importantly,
exclusively
produced
radicals,
avoiding
less
effective
pathway.
efficiency
due
CTTI's
energy
gap
low
reduction
potential,
which
favor
electron
transfer
O
generation.
Finally,
NPs
successfully
fabricated
encapsulating
liposomes,
validated
be
killing
cells,
even
under
conditions,
making
them
hypoxia‐tolerant
phototheranostic
agents
both
vitro
vivo
applications.
Chemical & Biomedical Imaging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Aggregation-induced
emission
luminogens
(AIEgens)
have
been
prosperously
developed
and
applied
in
the
fields
of
optical
imaging
theranostics
since
its
establishment.
Nowadays,
AIEgens
can
fulfill
nearly
all
requirements
with
spectra
ranging
from
visible
to
near-infrared
wavelengths.
Although
a
variety
varying
wavelengths
functionalities
continuously
designed,
their
performance
is
heavily
dependent
on
use
conventional
light
sources,
such
as
xenon
lamps
lasers,
which
severely
hinder
further
applications
due
limited
penetration
depth
background
autofluorescence
biological
tissues.
To
mitigate
these
limitations
maximize
potential
AIEgens,
unconventional
excitation
sources
chemical
energy,
ultrasound,
X-ray
offer
effective
alternatives
that
circumvent
drawbacks
associated
traditional
light-based
constant
excitation.
In
this
Review,
we
introduce
fundamental
principles
governing
combination
highlight
recent
advancements
using
excited
by
for
bioimaging
theranostics,
discuss
current
challenges
future
perspectives
aimed
at
advancing
biomedical
AIEgens.
Acta Biomaterialia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
malignant
disease
of
liver.
Although
immunotherapy
offers
new
opportunities
for
treating
advanced
HCC,
its
therapeutic
effect
still
limited
by
immunosuppressive
tumor
microenvironment
(TME).
Herein,
a
nanosensitizer
RGD@Ce6@MSA-2@Liposome
(RCM-Lip)
synthesized
to
specifically
initiate
HCC
immune
through
sonodynamic
therapy
(SDT)-triggered
immunogenic
cell
death
(ICD)
and
MSA-2-activated
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway.
RCM-Lip
consists
sonosensitizer
(Chlorin
e6,
Ce6)
with
STING
agonist
(MSA-2)
targeting
peptide
RGD
inserted
on
outer
liposome
surface.
Under
ultrasound
irradiation,
generates
reactive
oxygen
species
that
induce
cytotoxicity
apoptosis
cells.
Meanwhile,
antigens
released
are
taken
up
dendritic
cells
(DCs),
while
activated
in
DCs
MSA-2.
Moreover,
DC
maturation
stimulated,
further
enhancing
systematic
anti-tumor
responses.
Sono-immunotherapy
mediated
promotes
infiltration
CD8+
T
cells,
increasing
inflammatory
cytokine
secretion.
Consequently,
immunologically
"cold"
TME
successfully
turned
into
"hot"
one,
leading
significant
suppression
good
bio-safety.
These
results
suggest
promising
method
precise
synergistic
cancer
sono-immunotherapy.
STATEMENT
OF
SIGNIFICANCE:
Our
study
addressed
dilemma
hepatocellular
as
an
immunological
application
(SDT)
agonist.
The
cGAS-STING
signaling
pathway
plays
pivotal
role
innate
immunity
against
cancer,
but
clinical
agonists
were
hampered
responses
due
off-target
activation.
innovative
solution
introduces
RGD-targeted
encapsulate
agonist,
strengthening
effects
reducing
systemic
toxicity.
targeted
sono-immunotherapy
promoted
producing
intense
tumor-killing
mice
model
As
result,
one.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Sonocatalytic
therapy
(SCT)
has
emerged
as
a
promising
noninvasive
modality
for
tumor
treatment
but
is
hindered
by
the
insufficient
generation
of
ultrasound-induced
reactive
oxygen
species
(ROS)
and
hypoxic
microenvironments.
Herein,
we
fabricated
carbon
nanoframe-confined
N-coordinated
manganese
single-atom
sonocatalyst
with
five-coordinated
structure
(MnN
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
35(2)
Published: Nov. 18, 2024
Abstract
Ultrasound
(US)
becomes
an
appealing
modality
for
stimulating
or
amplifying
immune
responses
during
cancer
therapy,
which
is
also
termed
sono‐immunotherapy.
However,
the
clinical
prospect
has
not
been
fully
realized
due
to
scarcity
of
efficient
sonosensitizers.
Herein,
first
time
a
novel
Os‐doped
Au‐tri(pyridin‐4‐yl)
amine
coordination
structure
(Os@Au‐TPA)‐based
sonosensitizer
originally
designed
and
synthesized
sono‐immunotherapy
breast‐metastasized
tumors.
Impressively,
Os@Au‐TPA
shows
much
higher
US‐mediated
1
O
2
‐producing
activity
than
Au‐TPA
as
well
other
traditional
sonosensitizers,
example,
≈41.6
folds
ce6,
19.5
times
Protoporphyrin
IX
(PpIX),
12.0
Indocyanine
Green
(ICG),
11.1
Iron
phthalocyanine
(Pc(Fe)).
The
can
only
generate
abundant
ROS
upon
US
irradiation
implement
sonodynamic
therapy
(SDT),
cell
apoptosis
further
immunogenic
death,
but
alleviate
hypoxia
promote
polarization
M2
M1
macrophages
enhance
tumor
immunogenicity.
As
result,
when
combined
with
PD‐L1
antibody,
it
remodels
immunosuppressive
microenvironment,
achieves
concurrent
sonodynamic‐triggered
activation,
eradicates
both
original
distant‐metastasized
tumors
efficiently.
This
work
provides
new
strategy
construct
potent
sonosensitizers
from
pyridine‐metal
structures
proves
that
high
performance
are
crucial
in
boosting
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
17(1), P. 34 - 34
Published: Dec. 30, 2024
Background/Objectives:
The
two
obstacles
for
treating
glioma
are
the
skull
and
blood
brain–barrier
(BBB),
first
of
which
forms
a
physical
shield
that
increases
difficulties
traditional
surgery
or
radiotherapy,
while
latter
prevents
antitumor
drugs
reaching
tumor
sites.
To
conquer
these
issues,
we
take
advantage
high
penetrating
ability
sonodynamic
therapy
(SDT),
combined
with
novel
nanocomplex
can
easily
pass
BBB.
Methods:
Through
ultrasonic
polymerization,
amphiphilic
peptides
(C18GR7RGDS)
were
self-assembled
as
spherical
shell
encapsulating
sonosensitizer
Rose
Bengal
(RB)
plant-derived
compound,
sulforaphane
(SFN),
to
form
SFN@RB@SPM.
Results/Conclusions:
SFN@RB@SPM
be
internalized
by
cells
through
tumor-targeting
motif
RGDS
(abbreviated
peptide
sequence
composed
arginine,
glycine,
aspartic
acid,
serine),
further
executes
function
during
SDT.
Also,
could
taken
up
U87-MG
cross
BBB
in
glioma-bearing
mice
mechanism
investigation
revealed
that,
compared
SFN-free
(RB@SPM),
induced
much
more
apoptosis
an
ROS-dependent
manner
depletion
glutathione
SFN
cavitation
effect
In
animal
experiments,
besides
significant
reduction
volume
delay
losing
body
weight,
H&E
staining
showed
massive
infiltration
neutrophils
adjacent
sites,
indicating
this
synergistically
augment
SDT
efficacy,
partially
enhancing
innate
immunity.
