Recent Advances in Drug Delivery and Formulation,
Journal Year:
2024,
Volume and Issue:
18(4), P. 262 - 275
Published: Aug. 7, 2024
:
The
buccal
cavity,
also
known
as
the
oral
is
a
complex
anatomical
structure
that
plays
crucial
role
in
various
physiological
processes.
It
serves
gateway
to
digestive
system
and
facilitates
initial
stages
of
food
digestion
absorption.
However,
its
significance
extends
beyond
mere
it
presents
promising
route
for
drug
delivery,
particularly
brain.
Transferosomes
are
lipid-based
vesicles
have
gained
significant
attention
field
delivery
due
their
unique
properties.
These
composed
phospholipids
form
bilayer
structures
capable
encapsulating
both
hydrophilic
lipophilic
drugs.
Strategies
development
transferosomes
brain
emerged
avenues
pharmaceutical
research.
This
review
aims
explore
approaches
challenges
associated
with
harnessing
potential
means
enhancing
By
understanding
function
tissue
transferosomes,
researchers
can
develop
effective
formulation
methods
characterization
techniques
optimize
delivery.
Furthermore,
strategic
success
stories
transferosome
highlighted,
showcasing
inspiring
examples
demonstrate
revolutionize
Bulletin of the National Research Centre/Bulletin of the National Research Center,
Journal Year:
2024,
Volume and Issue:
48(1)
Published: Jan. 22, 2024
Abstract
Background
Tobacco
smoking
remains
a
major
preventable
cause
of
disease
and
death
worldwide.
Combustible
cigarettes
release
thousands
chemicals
that
can
initiate
inflammatory
pathways
leading
to
smoking-related
illness.
This
review
aims
synthesize
current
scientific
knowledge
on
mechanisms
smoking-induced
disease,
epidemiological
trends,
clinical
strategies
from
recent
literature.
Main
body
the
abstract
At
cellular
level,
cigarette
smoke
triggers
oxidative
stress
through
reactive
oxygen
species
(ROS),
causing
DNA
damage.
provokes
signaling
cascades
mediated
by
damage-associated
molecular
patterns
(DAMPs),
receptors
like
RAGE
TLRs,
downstream
cytokines.
Smoking
also
disrupts
apoptosis
autophagy.
In
lungs,
inflammation
play
central
roles
in
COPD
pathogenesis.
Smoking-induced
damage,
chronic
inflammation,
impaired
immunity
combine
promote
lung
carcinogenesis.
For
cardiovascular
endothelial
dysfunction,
platelet
activation,
atherogenesis
oxidized
LDL
effects
nitric
oxide
adhesion
molecules.
Short
conclusion
Given
unequivocal
evidence
health
risks,
cessation
is
critical
reducing
disability.
Both
counseling
pharmacotherapy
have
proven
efficacy
for
quitting,
but
limited
long-term.
Emerging
nicotine
products
e-cigarettes
unknown
impacts
population
health.
Comprehensive
efforts
encompassing
prevention,
screening,
treatment
innovation,
harm
reduction,
policy
reform
focused
curbing
smoking-attributable
morbidity
mortality
are
warranted.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
201, P. 107085 - 107085
Published: Feb. 2, 2024
There
is
an
urgent
need
for
novel
fast-acting
antidepressants
adolescent
treatment-resistant
depression
and/or
suicidal
risk,
since
the
selective
serotonin
reuptake
inhibitors
that
are
clinically
approved
age
(i.e.,
fluoxetine
or
escitalopram)
take
weeks
to
work.
In
this
context,
one
of
main
research
lines
our
group
characterize
at
preclinical
level
approaches
rapid-acting
adolescence.
The
present
review
summarizes
potential
use
in
adolescence
non-pharmacological
options,
such
as
neuromodulators
(electroconvulsive
therapy
and
other
innovative
types
brain
stimulation),
well
pharmacological
including
consciousness-altering
drugs
(mainly
ketamine
but
also
classical
psychedelics)
cannabinoids
cannabidiol),
with
promising
responses.
Following
a
brief
analytical
explanation
depression,
we
general
introduction
each
therapeutical
approach
together
clinical
evidence
supporting
its
beneficial
extrapolated
from
prior
successful
examples
adults),
then
report
recent
ongoing
studies
will
aid
improving
inclusion
these
therapies
clinic,
by
considering
sex-,
age-,
dose-related
differences,
factors
might
affect
efficacy
long-term
safety.
Finally,
conclude
providing
future
avenues
maximize
treatment
response,
more
importance
designing
testing
options
safe
depression.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(5), P. 4379 - 4402
Published: May 6, 2024
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
and
the
most
common
form
of
dementia
globally.
Although
direct
cause
AD
remains
under
debate,
neuroinflammation
oxidative
stress
are
critical
components
in
its
pathogenesis
progression.
As
result,
compounds
like
cannabidiol
(CBD)
being
increasingly
investigated
for
their
ability
to
provide
antioxidant
anti-inflammatory
neuroprotection.
CBD
primary
non-psychotropic
phytocannabinoid
derived
from
Cannabis
sativa.
It
has
been
found
beneficial
outcomes
variety
medical
conditions
gaining
increasing
attention
potential
therapeutic
application
AD.
not
psychoactive
lipophilic
nature
allows
rapid
distribution
throughout
body,
including
across
blood–brain
barrier
(BBB).
also
possesses
anti-inflammatory,
antioxidant,
neuroprotective
properties,
making
it
viable
candidate
treatment.
This
review
outlines
CBD’s
mechanism
action,
role
AD,
effectiveness
limitations
preclinical
models
Trends in Pharmacological Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Cannabidiol
(CBD),
the
primary
non-intoxicating
compound
in
cannabis,
is
currently
approved
for
treating
rare,
treatment-resistant
seizures.
Recent
preclinical
research
suggests
that
CBD's
multifaceted
mechanisms
of
action
brain,
which
involve
multiple
molecular
targets,
underlie
its
neuroprotective,
anti-inflammatory,
anxiolytic,
and
antipsychotic
effects.
Clinical
trials
are
also
exploring
therapeutic
potential
beyond
current
uses.
This
review
focuses
on
polypharmacological
profile
discusses
latest
clinical
findings
regarding
efficacy
neuropsychiatric
disorders.
Existing
evidence
ability
to
modulate
signaling
pathways
may
benefit
disorders,
we
propose
further
areas
clarify
mechanisms,
address
data
gaps,
refine
indications.
Behavioural Neurology,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 17
Published: Oct. 12, 2023
Cannabidiol
(CBD),
derived
from
Cannabis
sativa,
has
gained
remarkable
attention
for
its
potential
therapeutic
applications.
This
thorough
analysis
explores
the
increasing
significance
of
CBD
in
treating
neurological
conditions
including
epilepsy,
multiple
sclerosis,
Parkinson's
disease,
and
Alzheimer's
which
present
major
healthcare
concerns
on
a
worldwide
scale.
Despite
lack
available
therapies,
been
shown
to
possess
variety
pharmacological
effects
preclinical
clinical
studies,
making
it
an
intriguing
competitor.
review
brings
together
most
recent
findings
endocannabinoid
neurotransmitter
systems,
as
well
anti-inflammatory
pathways,
that
underlie
CBD's
modes
action.
Synthesized
efficacy
safety
assessments
range
illnesses
are
included,
covering
human
trials,
vitro
animal
models.
The
investigation
includes
how
could
protect
neurons,
control
neuroinflammation,
fend
off
oxidative
stress,
manage
neuronal
excitability.
study
emphasizes
existing
studies
future
possibilities
research,
addressing
research
issues
such
regulatory
complications
contradicting
results,
advocates
further
ideal
dose
methodologies.
By
emphasizing
improve
patient
well-being,
this
presents
revised
viewpoint
suitability
intervention
illnesses.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
659, P. 124235 - 124235
Published: May 17, 2024
Pulmonary
delivery
is
an
efficient
route
of
administration
to
deliver
cannabidiol
(CBD)
due
the
high
bioavailability
and
fast
onset
action.
The
major
formulation
challenge
poor
aqueous
solubility
CBD.
This
study
aimed
produce
inhalable
CBD
powders
with
enhanced
characterise
their
solid-state
properties.
was
spray
freeze
dried
mannitol
or
trehalose
dihydrate
without
dipalmitoylphosphatidylcholine
(DPPC).
All
four
had
acceptable
yields
at
>
70
%
porous
spherical
particles.
two
crystalline
contained
less
residual
solvent
than
both
amorphous
ones.
addition
DPPC
did
not
affect
crystallinity
level
powders.
Instead,
made
particles
more
porous,
decreased
particle
size
from
19-23
µm
11-13
µm,
increased
0.36
µg/mL
over
2
µg/mL.
were
dispersed
a
low
resistance
RS01
inhaler,
showing
aerosol
performance
emitted
fractions
91-93
fine
<
5
34-43
%.
These
formulations
can
be
used
as
platform
other
cannabinoids
by
inhalation.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116271 - 116271
Published: May 24, 2024
Cannabidiol
(CBD),
one
of
the
most
important
active
ingredients
in
cannabis,
has
been
reported
to
have
some
pharmacological
effects
such
as
antibacterial
and
analgesic
effects,
therapeutic
potential
treatment
oral
diseases
cancer,
gingivitis
periodontal
diseases.
However,
there
is
a
lack
relevant
systematic
research
reviews.
Therefore,
based
on
etiology
clinical
symptoms
several
common
diseases,
this
paper
focuses
CBD
pulp
mucosal
cancer
temporomandibular
joint
The
distribution
function
its
receptors
cavity
are
also
summarized.
In
order
provide
reference
for
future
further
application
CBD,
we
summarize
possible
routes
administration
corresponding
characteristics.
Finally,
challenges
faced
while
applying
clinically
solutions
discussed,
look
future.
