BMC Endocrine Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 17, 2025
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
morbidity
and
mortality
among
individuals
with
type
2
diabetes
mellitus
(T2DM).
Inflammation,
marked
by
elevated
high-sensitivity
C-reactive
protein
(hs-CRP)
levels,
dyslipidaemia,
are
critical
contributors
to
atherosclerosis
cardiovascular
risk.
In
Nigeria,
where
T2DM
prevalence
rising,
there
need
for
more
comprehensive
risk
prediction
tools,
incorporating
both
traditional
newer
biomarkers
such
as
hs-CRP.
This
study
aimed
investigate
the
association
between
hs-CRP
levels
dyslipidaemia
in
Nigerian
patients
explore
potential
implications
prediction.
A
hospital-based
cross-sectional
was
conducted
150
age-matched
controls.
Data
on
socio-demographics,
medical
history,
clinical
characteristics,
laboratory
parameters,
including
lipid
profiles
were
collected.
The
relationship
parameters
assessed
using
Pearson's
correlation
coefficient
independent
t-tests.
exhibited
significantly
higher
(2.2
±
1.8
mg/L
vs.
1.2
1.0
mg/L,
p
<
0.001),
(p
blood
pressure
(SPB-
127.6
12.4
mmHg,
DBP-
77.6
6.6
mmHg
SBP-
119.6
10.8
72.1
8.0
mmHg;
=
0.001)
compared
However,
no
significant
found
parameters.
Although
direct
remains
an
important
marker
possibly
through
non-lipid
pathways,
inflammation-driven
endothelial
dysfunction.
Further
research
needed
evaluate
its
role
refining
assessment
population.
Not
applicable.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 14, 2025
Perinatal
growth
and
nutrition
have
been
shown
to
be
determinants
in
the
programming
of
different
tissues,
such
as
adipose
tissue,
predisposing
individuals
metabolic
alterations
later
life.
Previous
studies
documented
an
increased
risk
disturbances
low-grade
inflammation
prepubertal
children
with
a
history
extrauterine
restriction
(EUGR).
The
aim
this
study
was
evaluate
possible
resulting
from
impaired
during
early
childhood
their
impact
on
young
adult
health.
This
is
longitudinal,
descriptive
analytical
cohort
EUGR
recruited
at
age
followed
up
for
10
years
until
end
puberty.
Anthropometric
measurements,
blood
pressure,
biochemical
parameters
related
lipid
carbohydrate
metabolism
plasma
adipokines
cytokines
were
analyzed.
Compared
children,
adults
presented
abdominal
circumference
percentiles.
Moreover,
insulin
levels
homeostatic
model
assessment
resistance
(HOMA-IR)
index
higher
adults,
considerable
proportion
participants
(22%)
becoming
insulin-resistant
after
pubertal
development.
In
contrast,
arterial
hypertension
observed
36%
compared
18%
postpubertal
adults.
Lipid
values
within
normal
ranges
without
differences.
Adiponectin
leptin
remained
similar
adulthood,
decrease
resistin.
Individuals
which
emphasizes
importance
clinical
follow-up
prevent
development
further
future
associated
diseases.
Cardiovascular Diabetology,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: April 16, 2025
Abstract
Background
Insulin
resistance
(IR),
as
quantified
by
the
triglyceride
glucose
(TyG)
index,
and
visceral
obesity,
assessed
body
roundness
index
(BRI),
have
been
identified
pivotal
risk
factors
for
stroke.
However,
combined
impact
of
these
two
indicators
on
stroke
has
not
thoroughly
investigated.
This
study
aims
to
investigate
both
separate
associations,
well
potential
interactions,
between
TyG
and/or
BRI
with
respect
incidence.
Methods
cohort
encompassed
6621
respondents
who
were
free
at
baseline
from
China
Health
Retirement
Longitudinal
Study
(CHARLS).
Participants
categorized
based
median
values
or/and
BRI.
Cox
proportional
hazards
regression
models
employed
examine
associations
alone,
their
effects
Both
additive
multiplicative
interaction
further
estimated.
Results
Among
participants
aged
45
years
or
older,
mean
(SD)
age
was
58.06
(8.57)
years,
2951
(44.6%)
being
male.
During
a
follow-up
period
up
9
743
individuals
experienced
events.
Compared
low
BRI,
adjusted
hazard
ratios
(HRs)
follows:
1.36
(95%
confidence
interval
[CI]
1.05–1.75)
high
1.61
CI
1.27–2.05)
1.78
1.40–2.26)
Neither
nor
interactions
incident
statistically
significant.
The
combination
enhanced
predictive
capability
compared
either
biomarker
alone.
Conclusion
We
discovered
that
are
strongly
associated
joint
assessment
enhances
stroke,
underscoring
critical
role
IR
adiposity
in
identification
screening
risk.
Graphical
abstract
BMC Endocrine Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 17, 2025
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
morbidity
and
mortality
among
individuals
with
type
2
diabetes
mellitus
(T2DM).
Inflammation,
marked
by
elevated
high-sensitivity
C-reactive
protein
(hs-CRP)
levels,
dyslipidaemia,
are
critical
contributors
to
atherosclerosis
cardiovascular
risk.
In
Nigeria,
where
T2DM
prevalence
rising,
there
need
for
more
comprehensive
risk
prediction
tools,
incorporating
both
traditional
newer
biomarkers
such
as
hs-CRP.
This
study
aimed
investigate
the
association
between
hs-CRP
levels
dyslipidaemia
in
Nigerian
patients
explore
potential
implications
prediction.
A
hospital-based
cross-sectional
was
conducted
150
age-matched
controls.
Data
on
socio-demographics,
medical
history,
clinical
characteristics,
laboratory
parameters,
including
lipid
profiles
were
collected.
The
relationship
parameters
assessed
using
Pearson's
correlation
coefficient
independent
t-tests.
exhibited
significantly
higher
(2.2
±
1.8
mg/L
vs.
1.2
1.0
mg/L,
p
<
0.001),
(p
blood
pressure
(SPB-
127.6
12.4
mmHg,
DBP-
77.6
6.6
mmHg
SBP-
119.6
10.8
72.1
8.0
mmHg;
=
0.001)
compared
However,
no
significant
found
parameters.
Although
direct
remains
an
important
marker
possibly
through
non-lipid
pathways,
inflammation-driven
endothelial
dysfunction.
Further
research
needed
evaluate
its
role
refining
assessment
population.
Not
applicable.
