Tricolus simplicis (Coleoptera: Curculionidae: Scolytinae): a new pest of Robusta coffee (Coffea canephora) in Mexico

Journal of Economic Entomology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Tricolus simplicis Wood 1974 (Coleoptera: Curculionidae: Scolytinae) is reported to bore and reproduce on the branches of Robusta coffee (Coffea canephora) in Chiapas, Mexico. This first report T. associated with worldwide. The risk this insect poses for production discussed.

Language: Английский

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Chlorogenic acid alleviates the intestinal barrier dysfunction and intestinal microbiota disorder induced by cisplatin

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Introduction The intestinal mucosal barrier is an important line of defense for the body, protecting it from bacteria, endotoxins, and antigens. Cisplatin, a clinical chemotherapy medicine, found side effect with impairing epithelial cells’ structure function, even causes mucositis which patients immense suffering hinders process cancer treatment. Chlorogenic acid, as component only second to caffeine in coffee, has been proved contribution on cardiovascular gastrointestinal benefits. So, we investigate protective chlorogenic acid cisplatin induced function injury mice perspective gut microbiota. Methods C57BL/6J were divided into 4 groups, including control group, treatment group receiving intraperitoneal injections alongside (Cis + CGA1), last pre-treated before administration CGA2). inflammation factor IL-6, IL-1β, TNF-α colonic tissue serum detected, respectively. To explore protection barrier’s integrity, also detected fecal LPS expression occludin ZO-1 proteins colon tissue. And H&E staining was used study histopathological conditions Moreover, this article utilized16S rDNA sequencing analyze microbiota feces. Results reduced level both compared alone group. Furthermore, pretreatment notably improved integrity by enhancing tissues. 16S showed that diversity, elevating abundance Proteobacteria pro-inflammatory environment increased Firmicutes/Bacteroidetes (F/B) ratio. However, especially reversed F/B Discussion Microbiota diversity all results suggest able mitigate these disorder reduction cisplatin, effectively offer against inflammatory response destruction intestines caused cisplatin.

Language: Английский

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Fostering Coffee-Minds by Developing Customer Perspective from Simple Public Cupping: Study Case in Bumi Kopi, Malang

BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 165, P. 07002 - 07002

Published: Jan. 1, 2025

The massive growth through the trends toward coffee-lover communities has pushed new revolution of coffee waves in Indonesia, previously from second wave into third wave. In Malang area, this phenomenon at same time had brought challenges and opportunities, especially improving awareness for lovers, which a major role as coffee-shop customers. Moreover, study focused on describing customers semi-trained testers perspectives towards taste available species is provided by experiences simple public cupping. As many 31 9 have been chosen demonstration was conducted Bumi Kopi Coffee Shop, Malang. Four types samples; including Coffea arabica var typica (arabica), liberica (liberica), canephora robusta (robusta), Coffea. dewevrei (excelsa) used during test. findings based test showed that semi trained tend to enjoy fruity such found liberica, while excelsa also still enjoyed fewer Based research, its hoped if these activities could be improved, an creative business optimization part gastronomic tourism.

Language: Английский

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Coffee and cardiac arrhythmias: Up-date review of the literature and clinical studies

Cardiology Journal, Journal Year: 2022, Volume and Issue: 30(4), P. 654 - 667

Published: Aug. 1, 2022

Coffee, next to water, is the most consumed drink in world. Coffee contains over 1000 chemical compounds, popular of which are caffeine, chlorogenic acid, kahweol, cafestol and trigonelline. Numerous studies have shown beneficial effects coffee on cardiovascular system, nervous digestive system kidneys. Due high incidence cardiac arrhythmias, especially atrial fibrillation, influence consumption arrhythmogenesis remains a controversial clinically important issue. Many mechanisms by can increase decrease risk arrhythmias been described. Habitual moderate amounts seems lead less reflected results many clinical trials meta-analyzes. This review summarizes action heart muscle recent assessing impact various arrhythmias.

Language: Английский

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Potential Therapeutic Strategies in the Treatment of Metabolic-Associated Fatty Liver Disease

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1789 - 1789

Published: Oct. 8, 2023

Metabolic-associated Fatty Liver Disease is one of the outstanding challenges in gastroenterology. The increasing incidence disease undoubtedly connected with ongoing obesity pandemic. lack specific symptoms early phases and grave complications require an active approach to prompt diagnosis treatment. Therapeutic lifestyle changes should be introduced a great majority patients; but, many cases, adherence not satisfactory. There need for effective pharmacological therapy Metabolic-Associated Disease, especially before onset steatohepatitis. Currently, there are no recommendations on selection drugs treat liver steatosis prevent patients from progression toward more advanced stages (steatohepatitis, cirrhosis, cancer). Therefore, this Review, we provide data clinical efficacy therapeutic interventions that might improve course Disease. These include used treatment hyperlipidemias, as well affecting gut microbiota endocrine system, other experimental approaches, including functional foods. Finally, advice concomitant

Language: Английский

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Antihypertensive activity of different components of Veratrum alkaloids through metabonomic data analysis

Phytomedicine, Journal Year: 2023, Volume and Issue: 120, P. 155033 - 155033

Published: Aug. 17, 2023

Hypertension is a serious global public health issue. Blood pressure (BP) still not effectively controlled in about 20 - 30% of hypertensive patients. Therefore, it imperative to develop new treatments for hypertension. Veratrum alkaloids were once used the clinical treatment hypertension, mechanism which unclear. It was gradually phased out due adverse reactions.This study aimed investigate short-term and long-term hypotensive profiles different components spontaneously rats (SHRs) unveil their mechanisms action.Total alkaloid (V), component A (A), veratramine (M) quickly decreased BP within 30 min treatment, reduced renal cardiovascular damage, improved relevant biochemical indicators (nitric oxide [NO], endothelin-1 [ET-1], angiotensin II [Ang II)], noradrenaline [NE], etc) SHRs delay stroke occurrence. Thereinto, exhibited excellent protective effects disease. The metabolomic treated with V, A, M significantly from those vehicle. Thirteen metabolites identified as potential pharmacodynamic biomarkers. Through Kyoto Encyclopedia Genes Genomes analysis, M-induced hypotension mainly related alterations nicotinate nicotinamide metabolism, GABAergic synapses, linoleic acid ketone body synthesis degradation, arginine proline urea cycle, metabolism key metabolic pathway relieve hypertension.This work shows that an effective promising antihypertensive agent hypertension reduce target organ mediated through modulating RAS, NO-ET homeostasis.

Language: Английский

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Association of caffeine intake with all-cause and cardiovascular mortality in elderly patients with hypertension

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 20, 2022

Caffeine is widely consumed not only in coffee but also soft drinks and tea. However, the long-term health effects of caffeine are still controversial, especially people with high cardiovascular risk such as elderly patients hypertension.This study analyzed data from National Health Nutrition Examination Survey 2003-2018. intake was calculated by two 24-h dietary recall interviews. Complex sampling-weighted multivariable Cox proportional hazards models were used to compare hazard ratios (HRs) all-cause mortality hypertensive different (<10, 10 <100, 100 <200, 200 <300, ≥300 mg/day).This included 6,076 patients. The mean ± standard error follow-up duration 6.86 0.12 years. During this period, a total 2,200 deaths occurred, which 765 deaths. Taking < mg/day reference, moderate (200 <300 mg/day) had lower (HR, 0.70 [95% CI, 0.56-0.87]) 0.55 0.39-0.77]) mortality. benefit reducing significant female 0.65 0.50-0.85]) or well-controlled blood pressure 0.63 0.46-0.87]), male poorly controlled pressure. In addition, non-linear relationship analysis showed that lowest HRs (Non-linear p = 0.022) 0.032) present study.Moderate associated reduced

Language: Английский

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Long-term outcomes from the UK Biobank on the impact of coffee on cardiovascular disease, arrhythmias, and mortality: Does the future hold coffee prescriptions?

Global Cardiology Science and Practice, Journal Year: 2023, Volume and Issue: 2023(2)

Published: May 8, 2023

Coffee is a popular beverage and the most used psychostimulant worldwide. Habitual coffee consumption has been linked to growing list of health benefits; however, source longstanding debate. Recent observational studies have challenged misconception caffeine reported safety beneficial effects intake on range cardiovascular (CV) conditions, including coronary artery disease, arrhythmias, heart failure, stroke, leading decreased risk CVD, all-cause CVD mortality, being associated with favorable CV outcomes. However, mechanisms underlying protective remain speculative, there lack dedicated aimed at addressing impact different subtypes clinical outcomes such as arrhythmia, mortality. Study Results: The study included 449,563 UK Biobank participants, free problems enrollment (median age 58 years; 55.3% females). median follow-up time was 12.5 years. Drinking 4 5 cups/day ground (HR 0.83; 95% CI [0.76-0.91]; P < .0001) or 2 3 instant (HR, 0.88; [0.85-0.92]; (but not decaffeinated coffee) significant reduction in incident AF. up reductions CHD 0.89, [0.86-0.91], 0.0001), CCF 0.83, [0.79-0.87], ischemic stroke 0.84, [0.78-0.90], 0.0001). led mortality 0.86, [0.83-0.89], 0.0001) 0.82, [0.74-0.90], Consumption all levels significantly reduced There no difference incidence among categories across subtypes.The results from indicate that mild-to-moderate types improved lower disease death, caffeinated reducing Daily should be discouraged by physicians, even presence newly developed disease. Whether will prescribed future prevent improve depends further evaluation physiological elucidation specific consumption.

Language: Английский

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Effect of Caffeine in Hypertension

Current Problems in Cardiology, Journal Year: 2023, Volume and Issue: 48(11), P. 101892 - 101892

Published: July 1, 2023

Language: Английский

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Coffee Intake, Plasma Caffeine Levels, and Kidney Function: Two-Sample Mendelian Randomization Among East Asian and European Ancestries

Kidney International Reports, Journal Year: 2024, Volume and Issue: 9(4), P. 1083 - 1092

Published: Jan. 19, 2024

Previous Mendelian randomization (MR) studies for the coffee-kidney association have reported inconsistent relationships in European populations and never examined mediators of this association. We aimed to evaluate causal relationship using two-sample MR among both East Asian ancestries explore underlying mechanisms plasma caffeine levels.

Language: Английский

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