Porous, Oxygen Vacancy Enhanced CeO2–x Microspheres with Efficient Enzyme-Mimetic and Photothermal Properties DOI Creative Commons

Çağıl Zeynep Süngü Akdoğan,

Burcu Gökçal,

Mustafa Polat

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2022, Volume and Issue: 10(29), P. 9492 - 9505

Published: June 15, 2022

Porous, defective, gray cerium oxide (g-CeO2–x) microspheres 4.8 μm in size were synthesized as a multifunctional nanozyme with catalase-, peroxidase-, and oxidase-like activities by the reduction of monodisperse-porous (CeO2) microspheres. Higher Ce(III) atomic fraction, more oxygen vacancy, lower content on surface g-CeO2–x shown Raman X-ray photoelectron spectroscopy. Band gap energies plain CeO2 determined 3.0 2.4 eV, respectively. Reactive species (ROS) related to enzyme-mimetic activity singlet (1O2•) superoxide anion (•O2–) ESR Michaelis–Menten plots sketched for provided superior maximum substrate consumption rates Oxidase- peroxidase-like used developing colorimetric fluorometric protocols detection nitrite common pollutant, also exhibited photothermal response explained enhanced light adsorption originated from vacancies. A temperature elevation up 19 °C was obtained under near infrared laser irradiation at 808 nm. Photothermal accompanying makes porous promising synergistic therapy agent capable overcoming hypoxia generating additional ROS tumor microenvironment.

Language: Английский

A Rational Design of Metal–Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns DOI Creative Commons
Yonghua Tang, Yi Han,

Jiachen Zhao

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 30, 2023

Metal-organic frameworks (MOFs) have attracted significant research interest in biomimetic catalysis. However, the modulation of activity MOFs by precisely tuning coordination metal nodes is still a challenge. Inspired metalloenzymes with well-defined structures, series containing halogen-coordinated copper (Cu-X MOFs, X = Cl, Br, I) are employed to elucidate their structure-activity relationship. Intriguingly, experimental and theoretical results strongly support that halogen atoms directly regulates enzyme-like activities Cu-X influencing spatial configuration electronic structure Cu active center. The optimal Cu-Cl MOF exhibits excellent superoxide dismutase-like specific one order magnitude higher than reported Cu-based nanozymes. More importantly, performing enzyme-mimicking catalysis, nanozyme can significantly scavenge reactive oxygen species alleviate oxidative stress, thus effectively relieving ocular chemical burns. Mechanistically, antioxidant antiapoptotic properties achieved regulating NRF2 JNK or P38 MAPK pathways. Our work provides novel way refine nanozymes engineering microenvironment and, more significantly, demonstrating potential therapeutic effect ophthalmic disease.

Language: Английский

Citations

59
Self‐Driven Electricity Modulates d‐Band Electrons of Copper Single‐Atom Nanozyme for Boosting Cancer Therapy DOI

Songjing Zhong,

Cheng Xiong, Yunchao Zhao

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(48)

Published: July 21, 2023

Abstract Single‐atom nanozymes (SAzymes) are considered as the most promising candidates for natural enzymes due to their atomically dispersed active sites that closely resemble metal centers of counterparts. However, a significant challenge still exists improving catalytic activities, retarding practical applications. Herein, this article presents through application human self‐driven triboelectric device impose electrical stimulus, multiple enzyme‐like activities single‐atom copper nanozyme (Cu‐NC) remarkably improved, thereby boosting cancer cell oxidative damage and death realizing improved therapy. Under an stimulus with 20 V voltage, peroxidase, catalase, oxidase, glutathione oxidase like Cu‐NC all boost generation free radicals. Through calculation, work analyzes how modulates activity via decreasing adsorption energy H 2 O on Cu sites, increasing d xy orbital near Fermi level, shifting d‐band center Cu, facilitating reactions. This opens new perspectives nanoenzymes

Language: Английский

Citations

51
Biomedical potential of nanozymes: Harnessing redox enzyme mimicry for theranostic applications DOI
Somaye Shahraki,

Esmaeil Vaziri,

Ali Akbar Saboury

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215937 - 215937

Published: June 15, 2024

Language: Английский

Citations

30
Stabilizer-free MnO2 nanozyme with singlet-oxygen conducted high oxidase-like activity and fast catalysis capability for improving alkaline phosphatase assay DOI

Yang Gao,

Xiangcheng Gao, Haiwei Hou

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 404, P. 135280 - 135280

Published: Jan. 13, 2024

Language: Английский

Citations

22
Engineering metal-organic frameworks-based nanozymes for enhanced biomimetic catalytic sensing DOI
Zhong Wei Jiang, Xue Gong, Yi Wang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 178, P. 117862 - 117862

Published: July 10, 2024

Language: Английский

Citations

19
Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges DOI Creative Commons

Qingzhen Tian,

Shu Li, Zheng Tang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.

Language: Английский

Citations

18
Recent advancement in the detection of potential cancer biomarkers using the nanomaterial integrated electrochemical sensing technique: a detailed review DOI Creative Commons
Hema Bhardwaj,

ARCHANA ARCHANA,

Ashab Noumani

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 5(2), P. 475 - 503

Published: Jan. 1, 2024

Graphical representation of the overview lung and oral cancer from detection to medical treatment.

Language: Английский

Citations

17
Single-Atom-Based Nanoenzyme in Tissue Repair DOI

Ziliang Fu,

Kexin Fan,

Xingjian He

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

Citations

17
Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment DOI Creative Commons
Liyin Wang, Min Gu, Xiaoli Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates poor patient prognosis. The heterogeneity complex biology of GBM, coupled with the protective nature blood–brain barrier (BBB), significantly limit efficacy traditional therapies. rapid development nanoenzyme technology presents promising therapeutic paradigm for rational targeted treatment GBM. In this review, underlying mechanisms GBM pathogenesis are comprehensively discussed, emphasizing impact BBB on strategies. Recent advances in nanoenzyme‐based approaches therapy explored, highlighting how these nanoenzymes enhance various modalities through their multifunctional capabilities potential precise drug delivery. Finally, challenges prospects translating laboratory research to clinical application, including issues stability, targeting efficiency, safety, regulatory hurdles critically analyzed. By providing thorough understanding both opportunities obstacles associated therapies, future directions aimed be informed contribute more effective treatments

Language: Английский

Citations

4
Nanozyme-based wearable biosensors for application in healthcare DOI Creative Commons
Yingcong Zhang, Yiran Yang,

Zhixin Yin

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111763 - 111763

Published: Jan. 7, 2025

Recent years have witnessed tremendous advances in wearable sensors, which play an essential role personalized healthcare for their ability real-time sensing and detection of human health information. Nanozymes, capable mimicking the functions natural enzymes addressing limitations, possess unique advantages such as structural stability, low cost, ease mass production, making them particularly beneficial constructing recognition units biosensors. In this review, we aim to delineate latest advancements nanozymes development biosensors, focusing on key developments nanozyme immobilization strategies, technologies, biomedical applications. The review also highlights current challenges future perspectives. Ultimately, it aims provide insights research endeavors rapidly evolving area.

Language: Английский

Citations

3