Liver Transplantation 2023: Status Report, Current and Future Challenges

Clinical Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 21(8), P. 2150 - 2166

Published: April 20, 2023

Liver transplantation offers live-saving therapy for patients with complications of cirrhosis and stage T2 hepatocellular carcinoma. The demand organs far outstrips the supply, innovations aimed at increasing number usable deceased donors as well alternative donor sources are a major focus. etiologies shifting over time, more need among alcohol-associated liver disease nonalcoholic/metabolic fatty less viral hepatitis, although hepatitis B remains an important indication transplant in countries high endemicity. rise has brought attention to how selected strategies needed prevent recurrent disease. In this review, we present status report on most pressing topics future challenges.

Language: Английский

---

International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates—2024

The Journal of Heart and Lung Transplantation, Journal Year: 2024, Volume and Issue: 43(10), P. 1529 - 1628.e54

Published: Aug. 8, 2024

Language: Английский

---

EASL Clinical Practice Guidelines on liver transplantation

Journal of Hepatology, Journal Year: 2024, Volume and Issue: 81(6), P. 1040 - 1086

Published: Oct. 31, 2024

Language: Английский

---

Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(11), P. 724 - 737

Published: Aug. 24, 2022

Language: Английский

---

Heart transplantation: advances in expanding the donor pool and xenotransplantation

Nature Reviews Cardiology, Journal Year: 2023, Volume and Issue: 21(1), P. 25 - 36

Published: July 14, 2023

Language: Английский

---

COVID-19 and hepatic injury: Diversity and risk assessment

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(3), P. 425 - 449

Published: Jan. 12, 2023

The coronavirus disease 2019 (COVID-19) represents a global health and economic challenge. Hepatic injuries have been approved to be associated with severe acute respiratory syndrome (SARS-CoV-2) infection. viral tropism pattern of SARS-CoV-2 can induce hepatic either by itself or worsening the conditions patients diseases. Besides, other factors reported play crucial role in pathological forms induced SARS-CoV-2, including cytokine storm, hypoxia, endothelial cells, even some treatments for COVID-19. On hand, several groups people could at risk COVID-19 complications, such as pregnant women neonates. present review outlines discusses interplay between infection injury, illness comorbidity, factors. it is focused on vaccination process developed vaccines preventing due

Language: Английский

---

Perspectives and Tools in Liver Graft Assessment: A Transformative Era in Liver Transplantation

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 494 - 494

Published: Feb. 17, 2025

Liver transplantation is a critical and evolving field in modern medicine, offering life-saving treatment for patients with end-stage liver disease other hepatic conditions. Despite its transformative potential, faces persistent challenges, including global organ shortage, increasing prevalence, significant waitlist mortality rates. Current donor evaluation practices often discard potentially viable livers, underscoring the need refined graft assessment tools. This review explores advancements utilization aimed at expanding pool optimizing outcomes. Emerging technologies, such as imaging techniques, dynamic functional tests, biomarkers, are increasingly assessment, especially marginal grafts. Machine learning artificial intelligence, exemplified by tools like LiverColor, promise to revolutionize donor-recipient matching viability predictions, while bioengineered grafts offer future solution shortage. Advances perfusion techniques improving preservation function, particularly donation after circulatory death (DCD) While challenges remain-such rejection, ischemia-reperfusion injury, recurrence of disease-technological procedural driving improvements allocation, preservation, post-transplant highlights potential integrating technologies multidisciplinary approaches expand improve equity survival rates transplantation.

Language: Английский

---

Transplantation of organs from SARS‐CoV‐2‐positive donors: Preliminary experience from Spain

Transplant Infectious Disease, Journal Year: 2023, Volume and Issue: 25(1)

Published: Jan. 19, 2023

The utilization of non-lung organs from deceased donors with a positive polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the time donation can be lifesaving, although safety this policy must assessed.This is nationwide, prospective study, reporting experience on SARS-CoV-2-positive between December 15, 2020 and May 31, 2022 in Spain.A total 69 patients received solid organ transplant (41 kidney, 18 liver, 8 heart, combined liver-kidney) obtained 32 SARS-CoV-2 PCR (four them cycle threshold value <30). All recipients tested negative were free disease 2019 (COVID-19) symptoms prior to transplantation. Nasopharyngeal swab turned 4 (5.8%) 3, 8, 11, 20 days after transplantation, though evidence did not support donor-derived COVID-19. Four kidney lost their grafts two died: one heart recipient due cardiogenic shock liver-kidney lung hypertension right failure. Graft losses patient deaths deemed unrelated donor status by treating teams. No other adverse reactions reported.This preliminary supports use than lungs PCR-positive donors, alignment previous series. However, impact infection upon quality should established future research.

Language: Английский

---

Is Transplantation With Coronavirus Disease 2019–Positive Donor Lungs Safe? A US Nationwide Analysis

The Annals of Thoracic Surgery, Journal Year: 2023, Volume and Issue: 116(5), P. 1046 - 1054

Published: July 27, 2023

Language: Английский

---

Severe community-acquired pneumonia in the post COVID-19 era

Current Opinion in Critical Care, Journal Year: 2023, Volume and Issue: 29(5), P. 400 - 406

Published: July 31, 2023

Purpose of review The aim was to examine and summarize the most recent published literature in last years stating advances for treatment options adjunctive therapies patients hospitalized with severe community-acquired pneumonia (sCAP). Search performed PubMed, including observational studies, randomized controlled trials, systematic reviews meta-analyses, international guidelines. Recent findings Regardless a large number CAP guidelines, their recommendations are based on low-level evidence. Viruses have an increasing role as sCAP etiology impact mortality. Accordingly, it is imperative strengthen demand vaccines newer antivirals. Considering early monitoring immune response Influenza, may help evaluate personalized immunomodulatory strategy. Despite growing evidence, use corticosteroids therapy bacterial continues be controversial. Summary Mortality due still remains undesirably high. This fact strengthens need more high-quality research increase It also highlights clinicians aware level evidence stated recommendations, taking this into consideration before decision making.

Language: Английский

---