Wound Healing: From Passive to Smart Dressings

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(16)

Published: June 26, 2021

Abstract The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on healthcare systems. Although, application traditional wound dressings contributes to an effective healing outcome, yet, complexity process remains major health challenge. Recent advances materials fabrication technologies have led that provide proper conditions for healing. 3D‐printed dressings, biomolecule‐loaded as well smart flexible bandages are among recent alternatives been developed accelerate Additionally, new generation contains variety microelectronic sensors real‐time monitoring environment is able apply required actions support progress. Moreover, manufacturing enable development next dressing substrates, known electronic skin, whole physiochemical markers single platform. current study reviews importance emerging strategy care management highlights different types promoting process.

Language: Английский

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Immunomodulatory bioactive glasses for tissue regeneration

Acta Biomaterialia, Journal Year: 2021, Volume and Issue: 133, P. 168 - 186

Published: Aug. 18, 2021

The regulatory functions of the immune response in tissue healing, repair, and regeneration have been evidenced last decade. Immune cells play central roles responses toward inducing favorable regenerative processes. Modulating controlling cell (particularly macrophages) is an emerging approach to enhance regeneration. Bioactive glasses (BGs) are multifunctional materials exhibiting osteogenic, angiogenic, antibacterial properties, being increasingly investigated for various scenarios, including bone wound healing. On other hand, immunomodulatory effects BGs relation regenerating tissues started be understood, key knowledge emerging. This first review article summarizing repair firstly introduced, discussing potential mechanisms regarding immunomodulation induced by BGs. Moreover, interactions between involved process (dissolution products) summarized detail. Particularly, a well-regulated timely switch macrophage phenotype from pro-inflammatory anti-inflammatory crucial constructive through modulating osteogenesis, osteoclastogenesis, angiogenesis. influence BG characteristics on discussed. We highlight strategies employed harness enhanced regeneration, incorporation active ions, surface functionalization, controlled release molecules. Finally, we conclude with our perspectives future research challenges directions field Immunomodulatory bioactive healing understood. summarize those studies which focused introduce Interactions processes (and their dissolution products, biologically ions) elaborated. modulate enhancing agents. outlining anticipate that increasing efforts will start emerge area

Language: Английский

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A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury

Bioactive Materials, Journal Year: 2022, Volume and Issue: 19, P. 550 - 568

Published: May 9, 2022

Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by complicated inflammation-related pathological processes, such as excessive reactive oxygen species (ROS) produced the infiltrated inflammatory immune cells released to extracellular microenvironment, leading widespread apoptosis of neuron cells, glial oligodendroctyes. In this study, a thioketal-containing ROS-scavenging hydrogel was prepared for encapsulation bone marrow derived mesenchymal stem (BMSCs), which promoted neurogenesis axon regeneration scavenging overproduced ROS re-building regenerative microenvironment. The could effectively encapsulate BMSCs, played remarkable neuroprotective role in vivo reducing production endogenous ROS, attenuating ROS-mediated oxidative damage downregulating cytokines interleukin-1 beta (IL-1β), interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α), resulting reduced cell spinal tissue. BMSCs-encapsulated also scar formation, improved tissue, thus distinctly enhanced motor functional recovery SCI rats. Our work provides combinational strategy against stress, with potential applications not only SCI, but other central nervous system diseases similar conditions.

Language: Английский

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Mussel-inspired collagen-hyaluronic acid composite scaffold with excellent antioxidant properties and sustained release of a growth factor for enhancing diabetic wound healing

Materials Today Bio, Journal Year: 2022, Volume and Issue: 15, P. 100320 - 100320

Published: June 1, 2022

Long-term non-healing diabetic wounds are always a serious challenge and global healthcare burden that needs to be resolved urgently in the clinic. Prolonged inflammation impaired angiogenesis main direct causes of wounds. With development polymer biomaterials, various wound dressings have been created, but few them applied clinical management Here, we developed mussel-inspired bioactive scaffold consisting mainly collagen hyaluronic acid, which natural biopolymer materials contained human tissues. First, fabricated different polydopamine modified lyophilized acid scaffolds under concentrations dopamine alkaline solutions, 0.5, 1, 2 ​mg/mL, so named CHS-PDA-0.5, CHS-PDA-1, CHS-PDA-2. After testing their physical chemical properties, antioxidant effect, regulation, as well drug loading release capabilities, obtained endothelial growth factor (EGF)-loaded dressing, [email protected], can resist reactive oxygen species (ROS) promote regeneration chronic rats by reducing inflammation. In addition, showed excellent swelling ability, certain coagulation effect reasonable degradation. Therefore, has great potential used treatment low-cost easily available dressing accelerate healing.

Language: Английский

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Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: Feb. 24, 2023

Osteoarthritis (OA) is a degenerative disease that often causes cartilage lesions and even osteochondral damage. Osteochondral defects induced by OA are accompanied an inflammatory arthrosis microenvironment with overproduced reactive oxygen species (ROS), resulting in the exacerbation of difficulty regenerating tissues. Therefore, it urgently needed to develop scaffolds can not only promote integrated regeneration subchondral bone, but also possess ROS-scavenging ability protect tissues from oxidative stress. Herein, zinc-cobalt bimetallic organic framework (Zn/Co-MOF) functionalized bioceramic designed for repairing under environment. By functionalizing Zn/Co-MOF on 3D-printed beta-tricalcium phosphate (β-TCP) scaffolds, β-TCP (MOF-TCP) broad-spectrum successfully developed. Benefiting its catalytic active sites degradation products, endows excellent antioxidative anti-inflammatory properties cells ROS invasion, as well dual-bioactivities simultaneously inducing osteogenic chondrogenic differentiation vitro. Furthermore, vivo results confirm MOF-TCP accelerate bone severe defects. This study offers promising strategy treating other diseases.

Language: Английский

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Reactive oxygen species-responsive polymer drug delivery systems

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 2, 2023

Applying reactive polymer materials sensitive to biological stimuli has recently attracted extensive research interest. The special physiological effects of oxygen species (ROS) on tumors or inflammation and the application ROS-responsive polymers as drug-delivery systems in organisms have much attention. ROS is a vital disease signal molecule, unique accumulation pathological sites may enable deliver payload (such drugs, prodrugs, gene therapy fragments) targeted fashion. In this paper, progress their recent years were summarized analyzed. was reviewed from perspective nanoparticle drug delivery systems, multi-responsive hydrogels. It expected that our work will help understand future development trends field.

Language: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

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Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 27, 2024

Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected more effectively, aerogel-hydrogel biphase gels based on dextran are developed. The gel introduced this study exhibits antibacterial anti-inflammatory properties the process of wound therapy, contributing to accelerated healing. aerogel phase exceptional water-absorption capabilities, rapidly soaking up from wound, thereby fostering clean hygienic healing microenvironment. Concurrently, is enriched with hydrogen sulfide donors. Following water absorption formation hydrogel phase, it enables sustained release around sites. experiments confirm that sulfide, by promoting M2 macrophage differentiation reducing levels inflammatory factors, effectively diminishes local inflammation at site. Furthermore, sodium copper chlorophyllin component within demonstrates effective through photodynamic antimicrobial providing viable solution infection challenges.

Language: Английский

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Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone

Bioactive Materials, Journal Year: 2021, Volume and Issue: 10, P. 306 - 322

Published: Aug. 26, 2021

This essay analyzes the scientific evidence that forms basis of bioactive materials, covering fundamental understanding bioactivity phenomena and correlation with mechanisms biocompatibility biomaterials. is a detailed assessment performance in areas such as bone-induction, cell adhesion, immunomodulation, thrombogenicity antimicrobial behavior. Bioactivity modulation biological activity by characteristics interfacial region incorporates material surface immediate local host tissue. Although term 'bioactive material' widely used has well understood general meaning, it would be useful now to concentrate on this region, considered 'the zone'. are either due topographical/micromechanical characteristics, or biologically active species presented zone. Examples effects osteoblast - osteoclast balance, nanotopographical regulation bactericidal nanostructures. Regulation include their influence, especially metal ions, signaling pathways bone formation, role adhesion molecules peptides attachment, macrophage polarization immunoregulatory peptides. While much experimental data exists demonstrate potential phenomena, there considerable barriers effective clinical translation. shows solid existence associated some types biomaterials, when modified manner designed specifically induce activity.

Language: Английский

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Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing

Journal of Magnesium and Alloys, Journal Year: 2022, Volume and Issue: 10(12), P. 3327 - 3353

Published: Dec. 1, 2022

Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated researches composition design, preparation processing, surface modification, degradation modes Mg alloys. Nevertheless, mechanisms by which promote bone healing remain elusive. This review gives an account specific promoting from four aspects, immunomodulatory, angiogenesis, osteogenesis regulation osteoclast function. We highlight functional status interactions numerous cells that involved healing, including immune cells, osteogenic-related osteoclasts, endothelial (ECs), nerve etc., summarize signaling pathways involved, with aim provide basis support future investigation driving regeneration. More importantly, it provides rationale general new application fields.

Language: Английский

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