Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 20, 2024

Several studies suggest that topographical patterns influence nerve cell fate. Efforts have been made to improve functionality through this approach, focusing on therapeutic strategies enhance function and support structures. However, inadequate orientation can impede long-term efficiency, affecting tissue repair. Therefore, enhancing neurites/axons directional growth is crucial for better outcomes, reducing coiling, ensuring accurate fiber connections. Conflicting results exist regarding the effects of micro- or nano-patterns migration, growth, immunogenic response, angiogenesis, complicating their clinical use. Nevertheless, advances in lithography, electrospinning, casting, molding techniques intentionally control fate neuronal cells are being explored rapidly sustainably efficiency. It appears be accomplished by combining with nanomaterials, biological gradients, electrical stimulation. Despite promising unclear mechanism action, presence cones various directions, restriction outcomes morphological functional markers presented challenges utilizing method. This review seeks clarify how affect morphology function, highlighting potential benefits orientation, especially combined approaches.

Language: Английский

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Focal adhesion and actin orientation regulated by cellular geometry determine stem cell differentiation via mechanotransduction

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 182, P. 81 - 92

Published: May 9, 2024

Language: Английский

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Mechanically Flexible Polymeric Nanoneedle Arrays for Promoting Differentiation and Functional Activity of Neural Progenitor Cells

BioChip Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Biosensors serve as indispensable analytical tools in biomedical diagnostics, environmental monitoring, and personalized healthcare, offering operation simplicity, cost-effectiveness, high sensitivity, portability. Nanostructure integration has overcome traditional sensing platform limitations, particularly sensitivity response dynamics. These nanoscale materials-including nanoparticles, nanowires, nanosheets, nanotubes-leverage unique physicochemical properties such surface-to-volume ratio, quantum confinement effects, plasmonic interactions to enhance biosensor performance significantly. This review systematically analyzes recent advances nanostructure-based biosensing technologies, examining how nanomaterial engineering improves sensor selectivity, multifunctionality. Fundamental mechanisms are explored by which nanostructures electrochemical, optical, electrical performance, emphasizing low-abundance biomarkers complex biological matrices. Beyond technological innovations, practical applications evaluated across healthcare monitoring. Finally, current challenges outline future research directions, highlighting these technologies' potential addressed transform diagnostic capabilities outcomes.

Language: Английский

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Chronic Probing of Deep Brain Neuronal Activity Using Nanofibrous Smart Conducting Hydrogel‐Based Brain–Machine Interface Probes

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

The mechanical mismatch between microelectrode of brain–machine interfaces (BMIs) and soft brain tissue during electrophysiological investigations leads to inflammation, glial scarring, compromising performance. Herein, a nanostructured, stimuli‐responsive, conductive, semi‐interpenetrating polymer network hydrogel‐based coated BMIs probe is introduced. system interface composed cross‐linkable poly( N ‐isopropylacrylamide)‐based copolymer regioregular poly[3‐(6‐methoxyhexyl)thiophene] fabricated via electrospinning integrated into neural probe. coating's nanofibrous architecture offers rapid swelling response faster shape recovery compared bulk hydrogels. Moreover, the smart coating becomes more conductive at physiological temperatures, which improves signal transmission efficiency enhances its stability chronic use. Indeed, detecting acute neuronal deep signals in mouse model demonstrates that developed can record high‐quality action potentials, favorably modulating impedance capacitance. Evaluation vivo activity biocompatibility configuration shows successful recording lack substantial inflammatory long‐term. development conducting fibrous hydrogel bio‐interface potential overcome limitations current probes, highlighting promising properties as candidate for long‐term, detection activities applications such BMIs.

Language: Английский

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Energy Transfer from the Liquid Crystal Bulk to the Surface Enables Dynamic Topographies via Anisotropic Plasticized Networks

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Surfaces with dynamic topographies play a pivotal role in modern technology by providing adaptable surface properties functional coatings. Here, method for creating high deformation amplitude using plasticized liquid crystal polymeric networks is proposed. Low molecular weight 5CB selected as the plasticizer, which then integrated into polymer (LCNs) and oligomer longer main chains (LCONs). Upon actuation, LCN coating reaches an of 30%, 14% larger than that pure system. While LCON exhibits significant close to 70%, over 37% greater LCONs. The LCONs exhibit more pronounced deformations LCNs due their flexibility. A physical model explaining underlying mechanism further developed. applications these surfaces optical devices, facilitating transitions between specular reflections diffuse reflections, or diffraction are demonstrated.

Language: Английский

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Neuroscience-Driven Solutions for Speech Impairment

Advances in medical education, research, and ethics (AMERE) book series, Journal Year: 2025, Volume and Issue: unknown, P. 119 - 146

Published: Jan. 10, 2025

Speech impairment presents a significant challenge for aged and chronically ill individuals. Emerging assistive technologies offer promising solutions to improve their communication abilities. This discussion explores established options like Augmentative Alternative Communication (AAC) devices cutting-edge approaches Brain-Computer Interfaces (BCIs). Neuroprosthetics, field merging neuroscience biomedical engineering, aims replace or modulate damaged parts of the nervous system. We delved into potential optogenetics, neuroengineering devices, biosensors, highlighting contributions future advancements in speech assistance. The dialogue emphasized importance comprehensive approach, combining with ongoing research on areas synthetic biology. multi-faceted approach holds key empowering speech-impaired individuals fostering improved communication.

Language: Английский

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An Implantable Nanoelectrode for Simultaneous in-Situ Self-Referencing, Drug Delivery, and Reliable Fixed-Point Recording Within a Single Neuron

Published: Jan. 19, 2025

Language: Английский

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Extracellular Matrix Stiffness: Mechanotransduction and Mechanobiological Response-Driven Strategies for Biomedical Applications Targeting Fibroblast Inflammation

Polymers, Journal Year: 2025, Volume and Issue: 17(6), P. 822 - 822

Published: March 20, 2025

The extracellular matrix (ECM) is a dynamic network providing mechanical and biochemical cues that regulate cellular behavior. ECM stiffness critically influences fibroblasts, the primary producers, particularly in inflammation fibrosis. This review explores role of fibroblast-driven tissue remodeling, focusing on physicochemical biological mechanisms involved. Engineered materials, hydrogels, polydimethylsiloxane (PDMS) are highlighted for replicating tissue-specific stiffness, enabling precise control over cell–matrix interactions. surface functionalization substrate including collagen, polydopamine, fibronectin, enhances bioactivity fibroblast adhesion. Key mechanotransduction pathways, such as integrin signaling YAP/TAZ activation, related to regulating behaviors inflammatory responses. fibroblasts driving chronic diseases emphasizes their therapeutic potentials. Advances ECM-modifying strategies, tunable biomaterials hydrogel-based therapies, explored applications engineering, drug delivery, anti-inflammatory treatments, diagnostic tools accurate diagnosis prognosis stiffness-related diseases. integrates mechanobiology with biomedical innovations, comprehensive responses outlining future directions targeted therapies.

Language: Английский

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Electrodeposited coatings for neural electrodes: A review

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 282, P. 117492 - 117492

Published: April 17, 2025

Language: Английский

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