Strategies and Research Progress of Surface Antithrombotic Polymer Coating Under Inflammatory Conditions DOI

Zehong Xiang,

Honghong Chen, Feng Wu

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Cardiovascular diseases (CVD) is the leading causes of mortality globally. Various blood-contact medical devices, by applying anticoagulant coatings on material surface. Utilizing various anticoagulants and enhancing lubricity device surfaces can effectively reduce short-term thrombotic risks. However, thrombosis in long-term or medium-to-long-term implanted devices remains a significant challenge. Current evidence suggests that during prolonged implantation, immune rejection its matrix, along with chronic inflammation induced disease, are key contributors to late-stage thrombosis. Therefore, modulating under pathological conditions considered crucial for achieving antithrombotic objectives. This review summarizes several representative strategies based anti-inflammatory introduces some research contributions this area.

Language: Английский

Functionalization of Implantable Systems for Controlled Drug Delivery and Beyond DOI Creative Commons
Ana Blanco, José Crecente‐Campo, Marı́a José Alonso

et al.

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

Citations

0
Strategies and Research Progress of Surface Antithrombotic Polymer Coating Under Inflammatory Conditions DOI

Zehong Xiang,

Honghong Chen, Feng Wu

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Cardiovascular diseases (CVD) is the leading causes of mortality globally. Various blood-contact medical devices, by applying anticoagulant coatings on material surface. Utilizing various anticoagulants and enhancing lubricity device surfaces can effectively reduce short-term thrombotic risks. However, thrombosis in long-term or medium-to-long-term implanted devices remains a significant challenge. Current evidence suggests that during prolonged implantation, immune rejection its matrix, along with chronic inflammation induced disease, are key contributors to late-stage thrombosis. Therefore, modulating under pathological conditions considered crucial for achieving antithrombotic objectives. This review summarizes several representative strategies based anti-inflammatory introduces some research contributions this area.

Language: Английский

Citations

0