Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114991 - 114991
Published: July 4, 2023
Language: Английский
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(13), P. 1085 - 1085
Published: June 25, 2024
Carbon-based nanomaterials, such as carbon quantum dots (CQDs) and 2D nanosheets (graphene, graphene oxide, graphdiyne), have shown remarkable potential in various biological applications. CQDs offer tunable photoluminescence excellent biocompatibility, making them suitable for bioimaging, drug delivery, biosensing, photodynamic therapy. Additionally, CQDs' unique properties enable bioimaging-guided therapy targeted imaging of biomolecules. On the other hand, exhibit exceptional physicochemical attributes, with excelling biosensing also delivery antimicrobial applications, graphdiyne tissue engineering. Their properties, porosity high surface area, contribute to controlled release enhanced regeneration. However, challenges, including long-term biocompatibility large-scale synthesis, necessitate further research. Potential future directions encompass theranostics, immunomodulation, neural interfaces, bioelectronic medicine, expanding bioimaging capabilities. In summary, both hold promise revolutionize biomedical sciences, offering innovative solutions improved therapies diverse contexts. Addressing current challenges will unlock their full can shape medicine biotechnology.
Language: Английский
Citations
13
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 6, 2024
Abstract Transmembrane channels play a vital role in regulating the permeation process, and have inspired recent development of biomimetic channels. Herein, we report class artificial nanochannels based on DNAzyme-functionalized glass nanopipettes to realize delicate control channel permeability, whereby surface wettability charge can be tuned by metal ions DNAzyme-substrates, allowing reversible conversion between different permeability states. We demonstrate that reversibly switched four states showing distinct various functional molecules. By embedding into plasma membrane single living cells, achieve selective transport dye molecules across cell membrane. Finally, advanced functions including gene silencing miR-21 cancer cells Ca 2+ PC-12 cells. In this work, provide versatile tool for design rectifying with on-demand functions.
Language: Английский
Citations
7
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Cancer cells possess distinct bioelectrical properties, yet therapies leveraging these characteristics remain underexplored. Herein, we introduce an innovative nanobioelectronic system combining a piezoelectric barium titanate nanoparticle core with conducting poly(3,4-ethylenedioxythiophene) shell (BTO@PEDOT NPs), designed to modulate cancer cell bioelectricity through noninvasive, wireless stimulation. Our hypothesis is that acting as nanoantennas, BTO@PEDOT NPs convert mechanical inputs provided by ultrasound (US) into electrical signals, capable of interfering the bioelectronic circuitry two human breast lines, MCF-7 and MDA-MB-231. Upon US stimulation, viability MDA-MB-231 treated 200 μg mL-1 reduced significantly 31% 24%, respectively, while healthy mammary fibroblasts (HMF) were unaffected treatment. Subsequent assays shed light on how this approach could interact cell's mechanisms, namely, increasing intracellular reactive oxygen species (ROS) calcium concentrations. Furthermore, was able polarize membranes, halting their cycle potentially harnessing tumorigenic characteristics. These findings underscore crucial role in progression highlight potential systems emerging promising strategy for intervention.
Language: Английский
Citations
0
Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 37 - 69
Published: Jan. 1, 2025
Language: Английский
Citations
0
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 170, P. 117462 - 117462
Published: Nov. 23, 2023
Language: Английский
Citations
10
Polyhedron, Journal Year: 2023, Volume and Issue: 248, P. 116759 - 116759
Published: Dec. 1, 2023
Language: Английский
Citations
10
Small Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, circulatory system stands out as particularly vulnerable, drawing additional attention its cardiac toxicity. To address cardiovascular nanotoxicity and further promote safe use of nanotechnology, a comprehensive review cardiotoxicity induced is provided. The begins identifying current research trends hotspots this field via bibliometric analysis. Subsequently, based on objectively obtained hotspots, mechanism nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, cell death, reviewed discussed. Finally, strategies for mitigation are proposed. objective assist readers understanding facilitate application human health.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Photochemical & Photobiological Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123311 - 123311
Published: April 1, 2025
Language: Английский
Citations
0