Cardiovascular Complications of COVID-19 among Pregnant Women and Their Fetuses: A Systematic Review

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(20), P. 6194 - 6194

Published: Oct. 20, 2022

COVID-19 is a viral infectious disease leading to spectrum of clinical complications, especially cardiovascular. Evidence shows that this infection can potentially accompany worse outcome in pregnant women. Cardiovascular complications mothers and their fetuses are reported by previous studies. In systematic review, we aim investigate the cardiovascular during pregnancy fetus, according published literature. We systematically searched online databases PubMed, Scopus, Web Science, Google Scholar, using relevant keywords up April 2022. included all observational studies reporting among COVID-19-affected women fetuses. 74 containing 47582 cases. Pre-eclampsia, hypertensive disorders, cardiomyopathy, heart failure, myocardial infarction, thrombosis formation, alterations maternal-fetal Doppler patterns, maternal fetal arrhythmia were as complications. The highest incidences pre-eclampsia/eclampsia cases, studies, 69% 62%, lowest 0.5% 3%. bradycardia 20% 3%, regarding tachycardia, 5.4% 1%, respectively. SARS-CoV-2 be associated with mother, particularly pre-eclampsia failure. Moreover, cause arrhythmia.

Language: Английский

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An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection

Biotechnology and Genetic Engineering Reviews, Journal Year: 2022, Volume and Issue: 40(4), P. 3326 - 3345

Published: Sept. 12, 2022

Coronavirus disease 2019 (Covid-19) is a recent and current infectious pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Covid-19 may lead to the development of lung injury (ALI), distress (ARDS), extrapulmonary manifestations in cases. Down-regulation angiotensin-converting enzyme (ACE2) SARS-CoV-2 increases production angiotensin II (AngII), which release pro-inflammatory cytokines placental growth factor (PlGF). PlGF critical molecule involved vasculogenesis angiogenesis. stimulated AngII different inflammatory diseases through variety signaling pathways. are interacted infection resulting complications. Both progression disorders; therefore, we aimed this review highlight potential role PlGF/AngII axis Covid-19.

Language: Английский

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SARS Cov2 Infection and Preeclampsia. How an Infection Can Help Us To Know More About an Obstetric Condition

Published: May 2, 2023

In this review, we aimed to understand the relationship between SARS-CoV-2 infection and preeclampsia severity in infected pregnant women. Pregnant women with SARS- CoV-2 have been shown a significantly increased risk of maternal death, ICU admission, preterm delivery, stillbirth compared those without infection. The also increases SARS-CoV-2, particularly severe symptoms. We emphasize im-portance specialized clinical management prevent poor pregnancy outcomes situation. association COVID-19 (PE) is likely due multiple mechanisms, including direct effects virus on trophoblast function arterial wall, acute atherosis, local inflammation leading pla-cental ischemia, exaggerated inflammatory responses women, SARS-CoV-2-related myocardial injury, cytokine storm, thrombotic microan-giopathy. Emphasis has placed potential impact specifically relation complications, placental dysfunction, cardiovascular dysfunction. Undoubtedly, one diagnostic tools differentiate COVID-19-induced preeclampsia-like syndrome true use biomarkers, such as sFlt-1/PlGF ratio. wish highlight for injury associated in-crease mortality rate. Vaccination against general population particular, drastically reduced disease. There an urgent need continue follow-up these their children detect appearance sequelae disease or peristent COVID 19

Language: Английский

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COVID-19 and Hypertensive Disorders of Pregnancy (HDP): A Portuguese Multicentric Retrospective Cohort Study of HDP in SARS-CoV-2 Infected Patients

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: March 21, 2023

An increased incidence of hypertensive disorders pregnancy (HDP) has been reported among pregnant women infected by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), pathogen behind coronavirus disease-19 (COVID-19). Although it is primarily a infection, extra-pulmonary manifestations COVID-19 mimic those found in preeclampsia (PE). Moreover, two conditions share common risk factors and pathological mechanisms, hindering ability to understand interaction between them. Current literature on this topic controversial as there an overlap clinical laboratory findings, HDP can be overreported outcome with COVID-19. The aim our study assess whether association maternal SARS-CoV-2 infection HDP.We designed multicenter retrospective cohort data collected from five maternity hospitals Almada, Porto, Lisboa, Penafiel Coimbra, Portugal, March 2020 2021. We obtained sample 789 who were followed up or delivered their babies one participating centers. Each woman tested positive for real-time polymerase chain reaction test -- exposure group (n= 263), was paired negative (1:2), received same antenatal care had similar gestational age parity control (n=526). Data characteristics, medical history, obstetric outcomes, delivery. Outcomes: primary not SARS-CoV-2. secondary outcomes are across all severity subgroups modified odds set developing HDP. Results: There slightly increased, but statistically significant, PE (relative risk, RR, 1.33; 95% confidence interval, CI 0.68-2.57) group. no significant having PE/eclampsia/ hemolysis, elevated liver enzymes, low platelets, HELLP [X2(1) = 0.732; p 0.392] well hypertension (GH) 0.039; 1]. [X2(2) 0.402; 0.875), 1.529; 0.435] did modify each factor causing Conclusion: Our demonstrate observe significantly As current topic, clinicians should aware that possible complication further research studies urge better

Language: Английский

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Impact of COVID-19 pandemic on maternal and neonatal outcomes: A narrative review and evidence from the PregCovid registry

Journal of Reproductive Healthcare and Medicine, Journal Year: 2023, Volume and Issue: 4, P. 2 - 2

Published: Jan. 23, 2023

More than 533 million Coronavirus Disease 2019 (COVID-19) cases and associated 6 fatalities were reported globally whereas 43 0.5 deaths in India till June 2022. Maharashtra state alone about one-third of the total COVID-19 early period pandemic. The lack epidemiological, demographic, impact data on pregnant women newborns, advocated need for recording documenting population specific clinical management policy decisions India. PregCovid registry was launched April 2020 by Indian Council Medical Research-National Institute Research Reproductive Child Health, Mumbai, collaboration with Education Drugs Department, Government Maharashtra, Topiwala National College Bai Yamunabai Laxman Nair Charitable Hospital to gain insights into socio-epidemiological characteristics lab confirmed assess its maternal neonatal outcomes. has collected 8428 postpartum from 19 participating centers across a near real-time manner. first that delta variant (B.1.617.2) dominant second wave more lethal (case fatality rate 5.7%) alpha (0.7%) There also higher incidence moderate severe cases, intensive care admissions complications including pre-eclampsia, low birth weight preterm deliveries during wave. omicron third pandemic exhibited transmission compared previous two waves, causing surge but minimally impacting adverse further analyzed comorbidities, coinfections, twin pregnancies, outcomes, while providing crucial inputs improve newborn health model can be replicated at tertiary hospitals understand various maternal-neonatal evidence generated useful improved contributed decision vaccination envisions similar regional, national international registries form an consortium sharing reporting promote global level interventions advocates sustainable collective response coverage.

Language: Английский

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Hypertensive disorders of pregnancy and severe acute respiratory syndrome coronavirus-2 infection

Journal of Perinatal Medicine, Journal Year: 2023, Volume and Issue: 51(5), P. 623 - 627

Published: Feb. 1, 2023

We aimed to determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with an increased risk of hypertensive disorders (HDP).A multicenter retrospective cohort study all pregnant patients who had SARS-CoV-2 testing and delivered a large health system between March 2020 2021. Cases were stratified into two groups: tested positive for during vs. negative. The primary outcome HDP, defined as composite gestational hypertension, preeclampsia, hemolysis, elevated liver enzymes, low platelet count (HELLP Syndrome), eclampsia by standard criteria, was compared the groups. Statistical analysis included multivariable logistic regression adjust potential confounders such maternal demographics comorbidities. Patient ZIP codes linked neighborhood-level data from US Census Bureau's American Community Survey.Of 22,438 included, 1,653 (7.4%) infection. Baseline age, body mass index, race, ethnicity, insurance type, neighborhood-built environmental socioeconomic status, nulliparity, pregestational diabetes differed significantly SARS-CoV- not HDP those without (14.9 14.8%; aOR 1.06 95% CI 0.90-1.24).In this that universally-tested population several indicators, HDP.

Language: Английский

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COVID‐19 and preeclampsia: The unique and the mutually nonexclusive clinical manifestations

American Journal of Reproductive Immunology, Journal Year: 2023, Volume and Issue: 89(5)

Published: March 30, 2023

Abstract Preeclampsia (PE) is a serious, unpredictable hypertensive disorder of pregnancy present in around 8–10% all pregnancies resulting high rate maternal and fetal morbidity mortality. With the pathophysiology partially known, delivery only cure for PE. The disease sets due to multiple pathologic processes involving endothelial cell activation, inflammation, multiorgan damage syncytiotrophoblast stress. Though primary target organ lungs COVID‐19, other systemic manifestations which include dysfunction, dysregulated angiogenesis, thrombosis, liver injury, thrombocytopenia, hypertension kidney overlap with COVID‐19 patients show higher incidence PE as compared their noninfected counterparts vice versa. Similar clinical features make differential diagnosis challenging. For effective specific management, it important differentiate actual from like features. There are contradictory reports about accuracy diagnostic tools distinguishing severe available data, can be stated that common adverse event, may exacerbated by, or exacerbate, COVID‐19. Future research should focus on cohesive understanding manifestations, preventive strategies during pregnancy.

Language: Английский

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Association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy: prospective, population based cohort study

BMJ Medicine, Journal Year: 2023, Volume and Issue: 2(1), P. e000465 - e000465

Published: May 1, 2023

To study the association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy.Prospective, population based cohort study.All singleton pregnancies after 22 completed gestational weeks registered in Swedish Pregnancy Register Medical Birth Registry of Norway, from 1 March 2020 to 24 May 2022.312 456 individuals available for analysis (201 770 Sweden 110 686 Norway), with that reached 42 by end follow-up pregnancy registries, excluding before those a diagnosis pre-existing or onset 20 weeks.Newly was defined as composite outcome hypertension, pre-eclampsia, HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome, eclampsia, week one delivery. The investigated stratified Cox proportional hazard model, adjusting maternal age, body mass index, parity, smoking, region birth, education, income, coexisting medical conditions, previous pregnancy, number healthcare visits past year, vaccination against SARS-CoV-2. Pre-eclampsia also analysed separate outcome.Of 312 analysis, 8% (n=24 566) had any time 6% (n=18 051) 3% (9899) pre-eclampsia. not associated an increased risk (adjusted ratio 0.99, 95% confidence interval 0.93 1.04) pre-eclampsia (0.98, 0.87 1.10). results were similar all trimesters different periods corresponded dominance variants virus.This did find evidence

Language: Английский

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Impact of preeclampsia on the outcome of COVID-19 infection

Bali Medical Journal, Journal Year: 2023, Volume and Issue: 12(2), P. 1342 - 1346

Published: April 27, 2023

Link of Video Abstract: https://youtu.be/Pp9SqvVDzlw Backgrounds: The COVID-19 outbreaks began at 2020 and spreading fast throughout the world. Infection in pregnancy is associated with increasing number mortality morbidity reports as well preeclampsia (PE) cases complicating cases. This study aimed to analyze impact on outcome patients during determine effect these variables maternal neonatal mortality. Methods: A retrospective was performed 711 admitted Dr. Soetomo Hospital - 2021. Demographic, clinical, laboratory, complication, patient outcomes data were collected. Patients then classified without preeclampsia. Data collected from hospital medical records, statistical analysis carried out variables. Results: We reported pregnant COVID-19, which 510 (72%) had no 201 (28%) There statistically significant differences age, referral status, gestational age admission, comorbidities, complications, symptoms COVID-19. PE higher comorbidities severe performance than : > 50% preterm pregnancy, oxygen saturation < 90% admission 5.9% cases, 35.8% symptoms, 20.4 % suffered severity/ critical condition, 24.4% need ventilation support. However, there difference death between PE. Risk shows an increased risk infection: pulmonary edema, ICU Ventilation needed OR 18.9, 12.5, 5.1, 2.7, respectively. Conclusion: Preeclampsia increases patients.

Language: Английский

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COVID-19 associated liver injury: A general review with special consideration of pregnancy and obstetric outcomes

World Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 28(42), P. 6017 - 6033

Published: Nov. 9, 2022

Liver injury is an increasingly recognized extra-pulmonary manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Coronavirus disease 2019 (COVID-19) associated liver (COVALI) a clinical encompassing all patients with biochemical identified in the setting SARS-CoV-2 Despite profound implications, its pathophysiology poorly understood. Unfortunately, most information on COVALI derived from general population and may not be applicable to individuals under-represented research, including pregnant individuals. This manuscript reviews: Clinical features COVALI, leading theories existing literature during pregnancy, topic widely explored literature. Ultimately, we synthesized data perinatal populations that demonstrates hepatocellular transaminitis likely induced by systemic inflammation strongly severity poorer outcome, offered perspective approaching potentially COVID-19 positive patient obstetric setting.

Language: Английский

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