Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Language: Английский
Citations
8Radiolabeled multi-layered coated gold nanoparticles as potential biocompatible PET/SPECT tracers
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(15), P. 3659 - 3675
Published: Jan. 1, 2024
The demand for tailored, disease-adapted, and easily accessible radiopharmaceuticals is one of the most persistent challenges in nuclear imaging precision medicine. In this study, two radiotracers were developed to bind SPECT PET radionuclides.
Language: Английский
Citations
6Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal release tailored to high ROS levels within tumors. Despite the challenges posed by distribution heterogeneity and endogenous supply constraints, this review highlights strategic alliance ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective leveraging PDT-induced enhanced therapeutic efficacy. This delves into biological importance progression treatment. We elucidate detail operational mechanisms linkers, including thioether, thioketal, selenide, diselencide, telluride aryl boronic acids/esters, as well latest developments nanomedicines that integrate PDT strategies. These insights are intended inspire design innovative nanocarriers PDT.
Language: Английский
Citations
6Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxides NanoAlum reengineered from first-line drugs
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4665 - 4682
Published: Sept. 14, 2024
Aluminum adjuvants (Alum), approved by the US Food and Drug Administration, have been extensively used in vaccines containing recombinant antigens, subunits of pathogens, or toxins for almost a century. While Alums typically elicit strong humoral immune responses, their ability to induce cellular mucosal immunity is limited. As an alternative, layered double hydroxide (LDH), widely antacid, has emerged as novel class potent nano-aluminum (NanoAlum), demonstrating advantageous physicochemical properties, biocompatibility adjuvanticity both responses. In this review, we summarize compare advantages disadvantages Alum NanoAlum these properties performance adjuvants. Moreover, propose key features ideal demonstrate that LDH promising candidate summarizing its current progress immunotherapeutic cancer treatments. Finally, conclude review offering our integrated perspectives about remaining challenges future directions NanoAlum's application preclinical/clinical settings.
Language: Английский
Citations
4A comprehensive review on advances in nanoparticle-mediated cancer therapeutics: Current research and future perspectives
Cancer Pathogenesis and Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
4An Evaluation of the Potential Radiosensitization Effect of Spherical Gold Nanoparticles to Induce Cellular Damage Using Different Radiation Qualities
Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1038 - 1038
Published: Feb. 24, 2025
Global disparities in cancer prevention, detection, and treatment demand a unified international effort to reduce the disease's burden improve outcomes. Despite advances chemotherapy radiotherapy, many tumors remain resistant these treatments. Gold nanoparticles (AuNPs) have shown promise as radiosensitizers, enhancing effectiveness of low-energy X-rays by emitting Auger electrons that cause localized cellular damage. In this study, spherical AuNPs 5 nm 10 were characterized tested on various cell lines, including malignant breast cells (MCF-7), non-malignant (CHO-K1 MCF-10A), human lymphocytes. Cells treated with irradiated attenuated 6 megavoltage (MV) or p(66)/Be neutron radiation assess DNA double-strand break (DSB) damage, viability, cycle progression. The combination induced higher levels γ-H2AX foci micronucleus formation compared treatments X-ray alone. alone reduced kinetics increased accumulation G2/M phase, suggesting block For proliferation, significant effects only observed at concentration 50 μg/mL AuNPs, while lower concentrations had no inhibitory effect. Further research is needed quantify internalized correlate their unravel biological mechanisms radioenhancement.
Language: Английский
Citations
0Cell Death Mechanisms Produced by Carbon‐Based Nanoparticles
Journal of Nanotechnology, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Using carbon‐based nanoparticles, such as diamond, graphite, fullerene, and nanotubes, has increased their research possible strategies for drug delivery to control diseases, especially cancer. However, because these materials, when interacting with the living environment, release substances that are capable of inducing cell death by themselves, it is vital importance analyze type particle can induce. Although there different efforts describe kind nanoparticles used treat diseases cancer, no paper explains mechanisms induced nanoparticle systems. Therefore, this attempts gain cutting‐edge information on using nanopolymorphisms mechanism particles produce. In conclusion, carbon interact directly membranes, causing physical damage disturbing integrity membrane. This alteration mainly lead necrosis or apoptosis. The definition a predominant each depends dose‐dependent manner. Primarily, concentrations cytotoxicity were 100–500 μg/mL. several studies analyzed, was only find nanodiamonds proved not be cytotoxic.
Language: Английский
Citations
0LRG1-Targeted Camptothecin Nanomicelles with Simultaneous Delivery of Olaparib for Enhanced Colorectal Cancer Chemotherapy
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 13, 2025
Camptothecin (CPT), an effective topoisomerase I inhibitor used in colorectal cancer chemotherapy, often faces limitations due to severe toxicities. Addressing this, we developed OCENM, a nanomedicine featuring the CPT–ET conjugate─comprising cathepsin B-sensitive linker and CPT linked ET peptide targeting leucine-rich alpha-2-glycoprotein 1 (LRG1) encapsulating Olaparib, potent poly ADP-ribose polymerase (PARP) inhibitor. OCENM aims for precise delivery sites overexpressing LRG1, while Olaparib disrupts compromised DNA repair pathways, enhancing damage promoting increased tumor cell apoptosis. Our results show accumulates preferentially models through LRG1 triggers synergistic apoptosis dual action of enhanced inhibited mechanisms. This study not only highlights potential as strategic target but also underscores therapeutic promise combining with treatment.
Language: Английский
Citations
0Carbohydrate polymer-functionalized metal nanoparticles in cancer therapy: A review
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141235 - 141235
Published: Feb. 21, 2025
Language: Английский
Citations
0Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine
Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 178 - 178
Published: Feb. 28, 2025
Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.
Language: Английский
Citations
0