MedMat.,
Journal Year:
2024,
Volume and Issue:
1(2), P. 74 - 94
Published: Dec. 1, 2024
Cuproptosis,
a
newly
discovered
copper-dependent
mode
of
cell
death,
has
received
extensive
attention
in
the
field
cancer
therapy
due
to
its
specific
activation
pathway.
Rapid
accumulation
large
amounts
copper
ions
within
cells
achieve
overload
is
key
activating
cuproptosis.
Advanced
nanotechnology
offers
considerable
promise
for
delivering
cells,
which
copper-based
nanomaterials
have
been
proposed
evoke
cuproptosis-mediated
therapy.
However,
it
still
great
challenge
induce
specifically
tumors
and
efficiently
activate
subsequent
cuproptosis-related
molecular
pathways.
Therefore,
necessary
summarize
strategies
used
effectively
or
amplify
cuproptosis
based
on
currently
developed
nanomaterials,
providing
ideas
design
future.
In
this
review,
that
can
be
are
systematically
classified
selection.
Subsequently,
sensitization
using
provided
therapeutic
efficiency.
Meanwhile,
combination
therapies
maximizing
treatment
efficacy
delineated.
Ultimately,
remaining
challenges
feasible
future
directions
use
tumor
also
discussed.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(22), P. 6767 - 6777
Published: May 21, 2024
Efforts
to
prolong
the
blood
circulation
time
and
bypass
immune
clearance
play
vital
roles
in
improving
therapeutic
efficacy
of
nanoparticles
(NPs).
Herein,
a
multifunctional
nanoplatform
(BPP@RTL)
that
precisely
targets
tumor
cells
is
fabricated
by
encapsulating
ultrasmall
phototherapeutic
agent
black
phosphorus
quantum
dot
(BPQD),
chemotherapeutic
drug
paclitaxel
(PTX),
immunomodulator
PolyMetformin
(PM)
hybrid
membrane-camouflaged
liposomes.
Specifically,
cell
membrane
coating
derived
from
fusion
cancer
red
displays
excellent
targeting
efficiency
long
property
due
innate
features
both
membranes.
After
collaboration
with
aPD-L1-based
checkpoint
blockade
therapy,
boosted
immunotherapeutic
effect
obtained
elevated
dendritic
maturation
T
activation.
Significantly,
laser-irradiated
BPP@RTL
combined
aPD-L1
effectively
eliminates
primary
tumors
inhibits
lung
metastasis
4T1
breast
model,
offering
promising
treatment
plan
develop
personalized
antitumor
strategy.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Copper-based
nanoparticles
have
garnered
significant
interest
in
cancer
therapy
due
to
their
ability
induce
oxidative
stress
and
cuproptosis
cells.
However,
antitumor
effectiveness
is
constrained
by
the
dynamic
redox
balance
metabolic
shift
between
phosphorylation
glycolysis.
Here,
a
polydopamine-coated
copper-α-ketoglutaric
acid
(α-KG)
coordination
polymer
nanoparticle
(CKPP)
designed
for
combined
pyroptosis-cuproptosis
immunotherapy
amplifying
reactive
oxygen
species
(ROS)
production
regulating
cellular
metabolism.
The
intracellular
imbalance
achieved
through
synergistic
effects
of
α-KG-induced
mitochondrial
reprogramming,
photothermally
enhanced
superoxide
dismutase-like
activity
polydopamine,
glutathione
depletion
copper
ions.
multifaceted
modulation
results
substantial
increase
ROS
levels,
triggering
subsequent
pyroptosis
Furthermore,
α-KG
shifts
metabolism
from
glycolysis
phosphorylation,
thereby
enhancing
induced
combination
dyshomeostasis
inhibition
potent
enhancement
pyroptosis-cuproptosis-mediated
therapy.
In
murine
model
colorectal
cancer,
CKPP
exhibited
remarkable
anticancer
effect,
achieving
tumor
rate
96.3%
complete
eradication
two
out
five
cases.
Overall,
this
bio-engineered
metal-organic
nanocomposite
demonstrates
potential
treating
immunotherapy.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Abstract
Cuproptosis,
a
newly
identified
copper
(Cu)-dependent
form
of
cell
death,
stands
out
due
to
its
distinct
mechanism
that
sets
it
apart
from
other
known
death
pathways.
The
molecular
underpinnings
cuproptosis
involve
the
binding
Cu
lipoylated
enzymes
in
tricarboxylic
acid
cycle.
This
interaction
triggers
enzyme
aggregation
and
proteotoxic
stress,
culminating
death.
specific
has
yet
be
fully
elucidated.
recognized
sparked
numerous
investigations
into
role
tumorigenesis
cancer
therapy.
In
this
review,
we
summarized
current
knowledge
on
metabolism
link
cancer.
Furthermore,
delineated
mechanisms
roles
cuproptosis-related
genes
Finally,
offered
comprehensive
discussion
most
recent
advancements
ionophores
nanoparticle
delivery
systems
utilize
as
cutting-edge
strategy
for
treatment.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Studies
show
that
intracellular
accumulation
of
copper
ions
causes
cuproptosis,
potentially
enhancing
anticancer
immunity.
However,
the
induction
cuproptosis
inevitably
faces
challenges
due
to
low
deliver
efficiency
and
collateral
damage
normal
tissues.
This
paper
presents
a
self-amplified
nanoplatform
(CEL
NP)
composed
Cu2-
XS
hollow
nanospheres
(HNSs),
elesclomol
(ES),
phase-change
material
lauric
acid
(LA).
Under
NIR-II
laser
irradiation,
photothermal
energy
generated
by
HNSs
melts
LA,
facilitating
precise
release
ES
within
tumor
microenvironment.
Notably,
can
traverse
cell
membrane
form
ES-Cu(II)
complexes,
thereby
delivery
cells.
Excess
Cu(II)
also
reacts
with
endogenous
glutathione,
reducing
its
inhibitory
effect
on
cuproptosis.
Ultimately,
this
amplified
activate
immunogenic
death,
eliciting
robust
immune
response
promoting
suppression.
The
CEL
NP-mediated
offers
novel
approach
for
therapy
through
induction.
