The innate immune response is a key player in the process of coronary artery and aortic valve calcification DOI Creative Commons

I. F. Shlyk,

М. В. Харитонова, M. N. Morgunov

et al.

Medical Herald of the South of Russia, Journal Year: 2024, Volume and Issue: 15(4), P. 90 - 98

Published: Oct. 17, 2024

The presented literature review allows us to understand and supplement the existing ideas about pathogenesis of coronary calcification aortic valve at stage formation these changes. To study in detail participation most studied immunocompetent cells innate immunity, such as macrophages, dendritic mast cells, neutrophils, natural killers arteries valve, their functional role progression this process. also presents gaps missing data present cell populations, replenishment which will contribute development targeted therapy for search sources was conducted following databases: Scopus, web Science, MedLine, Cochrane Library, RSCI, Springer, Science Direct — taking into account year publication (no more than 10 years), language (English/Russian), availability full-text publications access them.

Language: Английский

Alternative splicing of vascular calcification: Insights, opportunities, and challenges DOI
Ying Sheng,

Hewen Wei,

Shengmin Lu

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111626 - 111626

Published: Jan. 1, 2025

Language: Английский

Citations

0
Role of macrophages in vascular calcification: From the perspective of homeostasis DOI Creative Commons

Rong Dong,

Zhenjun Ji, Mi Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113635 - 113635

Published: Nov. 19, 2024

Language: Английский

Citations

2
The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification DOI Creative Commons
Zhenghong Zhang,

Defan Wang,

Renfeng Xu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1592 - 1592

Published: Dec. 12, 2024

HIF-1α plays a crucial regulatory role in vascular calcification (VC), primarily influencing the osteogenic differentiation of VSMCs through oxygen-sensing mechanisms. Under hypoxic conditions, stability increases, avoiding PHD and VHL protein-mediated degradation, which promotes its accumulation cells then activates gene expressions related to calcification. Additionally, modulates metabolic state by regulating pathways that govern switch between glycolysis oxidative phosphorylation, thereby further advancing process. The interaction other signaling pathways, such as nuclear factor-κB, Notch, Wnt/β-catenin, creates complex network serves critical driving force VC. Therefore, deeper understanding mechanism during development progression VC is great significance, it not only key molecular marker for pathological mechanisms but also represents promising target future anti-calcification therapies.

Language: Английский

Citations

1
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats DOI Creative Commons
Astrid Van den Branden, Britt Opdebeeck, Saar Adriaensen

et al.

The Journal of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Arterial media calcification is a severe cardiovascular complication commonly manifesting in patients with chronic kidney disease (CKD). Patients CKD frequently undergo intravenous iron therapy to address deficiency. Iron suggested be sequestered vascular cells, potentially leading oxidative (lipid) stress and cell death, which are recognized as key contributors arterial calcification. The objective of this study was investigate the effect administration on CKD‐induced Therefore, adenine‐induced rats were treated intravenously checked for deposition calcification, well ferritin lipid peroxidation markers. Additionally, sections from who dialysis dependent analyzed these parameters. This showed that led signature. increased upon treatment correlated accumulation elevated peroxidation, but direct correlation lacking. Taken together, potential contributor process, instead being predominant factor, thereby emphasizing complexity multifactorial disease. © 2024 Author(s). Journal Pathology published by John Wiley & Sons Ltd behalf Pathological Society Great Britain Ireland.

Language: Английский

Citations

0
The innate immune response is a key player in the process of coronary artery and aortic valve calcification DOI Creative Commons

I. F. Shlyk,

М. В. Харитонова, M. N. Morgunov

et al.

Medical Herald of the South of Russia, Journal Year: 2024, Volume and Issue: 15(4), P. 90 - 98

Published: Oct. 17, 2024

The presented literature review allows us to understand and supplement the existing ideas about pathogenesis of coronary calcification aortic valve at stage formation these changes. To study in detail participation most studied immunocompetent cells innate immunity, such as macrophages, dendritic mast cells, neutrophils, natural killers arteries valve, their functional role progression this process. also presents gaps missing data present cell populations, replenishment which will contribute development targeted therapy for search sources was conducted following databases: Scopus, web Science, MedLine, Cochrane Library, RSCI, Springer, Science Direct — taking into account year publication (no more than 10 years), language (English/Russian), availability full-text publications access them.

Language: Английский

Citations

0