Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 10206 - 10217

Published: May 15, 2023

Cuproptosis shows good application prospects in tumor therapy. However, the copper efflux mechanism and highly expressed intracellular reducing substances can inhibit cuproptosis effects. In this study, a platelet vesicle (PV) coated cuprous oxide nanoparticle (Cu2O)/TBP-2 sensitization system (PTC) was constructed for multiple induction of cuproptosis. PTC prepared by physical extrusion AIE photosensitizer (TBP-2), Cu2O, PV. After biomimetic modification, enhance its long-term blood circulation targeting ability. Subsequently, rapidly degraded to release ions under acid conditions hydrogen peroxides cells. Then, light irradiation, TBP-2 quickly enters cell membrane generates hydroxyl radicals consume glutathione efflux. Accumulated cause lipoylated protein aggregation iron–sulfur loss, which result proteotoxic stress ultimately treatment target induce cells vitro vivo, significantly lung metastasis breast cancer, increase number central memory T peripheral blood, prevent rechallenge. It provides an idea design nanomedicine based on

Language: Английский

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Dual-targeting nanozyme combined with aPD-L1-based immunotherapy for combating cancer recurrence and metastasis

Materials Today, Journal Year: 2024, Volume and Issue: 73, P. 79 - 95

Published: Feb. 12, 2024

Language: Английский

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Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 204 - 215

Published: May 31, 2024

Language: Английский

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Advanced drug delivery platforms target cancer stem cells

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101036 - 101036

Published: Feb. 1, 2025

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

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Photothermal‐Triggered Sulfur Oxide Gas Therapy Augments Type I Photodynamic Therapy for Potentiating Cancer Stem Cell Ablation and Inhibiting Radioresistant Tumor Recurrence

Advanced Science, Journal Year: 2023, Volume and Issue: 10(29)

Published: Aug. 9, 2023

Despite advances in cancer therapy, the existence of self-renewing stem cells (CSC) can lead to tumor recurrence and radiation resistance, resulting treatment failure high mortality patients. To address this issue, a near-infrared (NIR) laser-induced synergistic therapeutic platform has been developed by incorporating aggregation-induced emission (AIE)-active phototheranostic agents sulfur dioxide (SO2 ) prodrug into biocompatible hydrogel, namely TBH, suppress malignant CSC growth. Outstanding hydroxyl radical (·OH) generation photothermal effect AIE agent actualizes Type I photodynamic therapy (PDT) through 660 nm NIR laser irradiation. Meanwhile, large amount SO2 is released from thermo-sensitive TBH gel, which depletes upregulated glutathione consequentially promotes ·OH for PDT enhancement. Thus, hydrogel diminish under irradiation finally restrain after radiotherapy (RT). In comparison, mice that were only treated with RT relapsed rapidly. These findings reveal double-boosting protocol, combination AIE-mediated gas provides novel strategy inhibiting growth RT, presents great potential clinical treatment.

Language: Английский

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Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146276 - 146276

Published: Oct. 11, 2023

Language: Английский

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Near‐infrared laser‐activated aggregation‐induced emission nanoparticles boost tumor carbonyl stress and immunotherapy of breast cancer

Aggregate, Journal Year: 2023, Volume and Issue: 5(2)

Published: Oct. 3, 2023

Abstract The induction of tumor carbonyl stress is reported to efficiently revert immune suppression in the microenvironment and enhance cancer immunotherapy. However, low oxygen concentration due inherent hypoxia limits its catalytic effect. Herein, an injectable thermosensitive hydrogel system (named APH) developed for co‐loading near‐infrared (NIR) aggregation‐induced emission (AIE) nanoparticles plasma amine oxidase (PAO) boosting enhancing antitumor immunity. Upon 808 nm NIR laser irradiation, AIE trigger a mild‐temperature (around 45°C) photothermal effect site, which significantly relieves promotes released PAO inhibit growth Myeloid‐derived suppressor cells. Remarkably, synergistic therapeutic APH verified through significant inhibitory on distant tumor, enhanced memory, effective postoperative recurrence, rechallenge, metastasis. Overall, combined AIE‐mediated therapy by upon irradiation can activate immunotherapy, making it promising treatment approach treatment.

Language: Английский

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Biomimetic Nano‐Cancer Stem Cell Scavenger for Inhibition of Breast Cancer Recurrence and Metastasis after FLASH‐Radiotherapy

Small, Journal Year: 2024, Volume and Issue: 20(29)

Published: Feb. 17, 2024

Abstract Compared to conventional radiotherapy (RT), FLASH‐RT delivers ultra‐high dose radiation, significantly reducing damage normal tissue while guaranteeing the effect of cancer treatment. However, recurrence and metastasis frequently occur after all RT due existence intractable stem cells (CSCs). To address this, a biomimetic nanoplatform (named TAFL) tumor‐derived exosome fusion liposomes is designed by co‐loading aggregation‐induced emission photothermal agents, TPE‐BBT, anti‐cancer drugs, aspirin, aiming clear CSCs for inhibiting therapy . Aspirin released in TAFL system triggered laser irradiation can induce apoptosis DNA 4T1 CSCs, comprehensively downregulate their stemness phenotype, inhibit sphericity. Furthermore, TPE‐BBT mediated mild‐photothermal alleviate hypoxic tumor microenvironment, repair which further amplifies aspirin against therefore reduces effective making more biologically safe. In vivo experimental results demonstrated that decreased population treatment inhibited therapy. summary, this provides new idea future clinical application

Language: Английский

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Cold exposure therapy combined with bionic type I aggregation-induced emission photosensitizer for enhanced immunotherapy of breast cancer

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101217 - 101217

Published: Aug. 24, 2024

Cold exposure therapy (CE), as an inexpensive method, has shown great potential in cancer therapy. Exploring the combined anti-tumor mechanism of CE and traditional therapies (such photodynamic (PDT)) is exciting promising. Here, a bionic aggregation-induced emission photosensitizer system (named THL) designed for to enhance immunotherapy. THL inherits homologous targeting ability tumor derived exosomes, promoting enrichment at site. Under external illumination, generates hydroxyl radicals superoxide anions through type I PDT. In addition, mice are pretreated with cold exposure, which promotes mediated PDT reactive oxygen species (ROS) generation by reducing production ATP GSH tissue. This combination increases ROS within tumor, inhibits growth distant tumors, recurrent rechallenged tumors number cytotoxic CD8+T cells memory T cells. Compared alone, shows greater advantages The strategy provides new ideas

Language: Английский

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