Psychosis
(including
symptoms
of
delusions,
hallucinations,
and
disorganized
conduct/speech)
is
a
main
feature
schizophrenia
frequently
present
in
other
major
psychiatric
illnesses.
Studies
individuals
with
first-episode
(FEP)
early
psychosis
(EP)
have
the
potential
to
interpret
aberrant
connectivity
associated
during
period
minimal
influence
from
medication
confounds.
The
current
study
uses
data-driven
approach
examine
patterns
functional
network
(FNC)
multi-site
dataset
comprising
resting-state
magnetic
resonance
images
(rs-fMRI)
117
FEP
or
EP
130
without
disorder,
as
controls.
Accounting
for
age,
sex,
race,
head
motion,
multiple
imaging
sites,
differences
FNC
were
identified
between
control
participants
cortical
(namely
inferior
frontal
gyrus,
superior
medial
postcentral
supplementary
motor
area,
posterior
cingulate
cortex,
middle
temporal
gyri),
subcortical
(the
caudate,
thalamus,
subthalamus,
hippocampus),
cerebellar
regions.
dysconnectivity
reported
here
may
indicate
disruptions
cortical-subcortical-cerebellar
circuitry
involved
rudimentary
cognitive
functions
serve
reliable
biomarkers
psychosis.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Schizophrenia
spectrum
disorders
(SSD)
are
characterized
by
atypical
brain
maturation,
including
reduced
structural
similarity
between
regions.
However,
the
maturational
and
neurobiological
underpinnings
of
complex
interactions
abnormal
development
network
reorganization
remain
poorly
characterized.
Using
MRI
data
from
195
healthy
controls
(HC)
352
individuals
with
SSD,
we
constructed
individual
Morphometric
INverse
Divergence
(MIND)
networks.
Compared
to
HC,
SSD
exhibited
in
temporal
cingulate
lobes,
more
pronounced
reductions
exhibiting
a
‘poor’
clinical
status
(more
impaired
cognitive
functioning
severe
symptomatology).
These
alterations
MIND
networks
were
associated
cortical
hierarchy
events,
locating
higher-order
association
areas
that
predominantly
mature
later.
Finally,
mapped
46
features
onto
revealing
high
presence
neurotransmitters,
astrocytes,
microglia,
along
decreased
metabolism
microstructure,
regions
SSD.
Taken
together,
these
findings
provide
evidence
on
interplay
dysconnectivity,
underlying
neurobiology
determining
Psychosis
(including
symptoms
of
delusions,
hallucinations,
and
disorganized
conduct/speech)
is
a
main
feature
schizophrenia
frequently
present
in
other
major
psychiatric
illnesses.
Studies
individuals
with
first-episode
(FEP)
early
psychosis
(EP)
have
the
potential
to
interpret
aberrant
connectivity
associated
during
period
minimal
influence
from
medication
confounds.
The
current
study
uses
data-driven
approach
examine
patterns
functional
network
(FNC)
multi-site
dataset
comprising
resting-state
magnetic
resonance
images
(rs-fMRI)
117
FEP
or
EP
130
without
disorder,
as
controls.
Accounting
for
age,
sex,
race,
head
motion,
multiple
imaging
sites,
differences
FNC
were
identified
between
control
participants
cortical
(namely
inferior
frontal
gyrus,
superior
medial
postcentral
supplementary
motor
area,
posterior
cingulate
cortex,
middle
temporal
gyri),
subcortical
(the
caudate,
thalamus,
subthalamus,
hippocampus),
cerebellar
regions.
dysconnectivity
reported
here
may
indicate
disruptions
cortical-subcortical-cerebellar
circuitry
involved
rudimentary
cognitive
functions
serve
reliable
biomarkers
psychosis.
