Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney

Environmental Pollution, Journal Year: 2023, Volume and Issue: 333, P. 121947 - 121947

Published: June 1, 2023

Language: Английский

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Ferroptosis Induced by Pollutants: An Emerging Mechanism in Environmental Toxicology

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(5), P. 2166 - 2184

Published: Jan. 26, 2024

Environmental pollutants have been recognized for their ability to induce various adverse outcomes in both the environment and human health, including inflammation, apoptosis, necrosis, pyroptosis, autophagy. Understanding these biological mechanisms has played a crucial role risk assessment management efforts. However, recent identification of ferroptosis as form programmed cell death emerged critical mechanism underlying pollutant-induced toxicity. Numerous studies demonstrated that fine particulates, heavy metals, organic substances can trigger ferroptosis, which is closely intertwined with lipid, iron, amino acid metabolism. Given growing evidence linking severe diseases such heart failure, chronic obstructive pulmonary disease, liver injury, Parkinson's Alzheimer's cancer, it imperative investigate ferroptosis. In this review, we comprehensively analyze pathways intricate signaling molecules elucidate integration into driving braking axes. Furthermore, discuss potential hazards associated organs four representative animal models. Finally, provide an outlook on future research directions strategies aimed at preventing By enhancing our understanding novel developing effective preventive measures, mitigate effects environmental safeguard health.

Language: Английский

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From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 14

Published: Aug. 10, 2022

Coronary heart disease (CHD) is closely related to oxidative stress and inflammatory response the most common cardiovascular (CVD). Iron an essential mineral that participates in many physiological biochemical reactions human body. Meanwhile, on negative side, iron has active redox capacity, which leads accumulation of reactive oxygen species (ROS) lipid peroxidation. There growing evidence disordered metabolism involved CHD’s pathological progression. And result associated with overload-induced programmed cell death, often called ferroptosis. That features iron-dependent Ferroptosis may play a crucial role development CHD, targeting ferroptosis be promising option for treating CHD. Here, we review mechanisms cardiomyocytes (CMs) explain correlation between highlight specific roles main progression

Language: Английский

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Lycium barbarum polysaccharide-glycoprotein ameliorates ionizing radiation-induced epithelial injury by regulating oxidative stress and ferroptosis via the Nrf2 pathway

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 204, P. 84 - 94

Published: April 28, 2023

Language: Английский

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Polystyrene micro- and nanoplastics induce gastric toxicity through ROS mediated oxidative stress and P62/Keap1/Nrf2 pathway

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169228 - 169228

Published: Dec. 13, 2023

Language: Английский

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Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2961 - 2986

Published: Aug. 10, 2024

Language: Английский

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A review of disrupted biological response associated with volatile organic compound exposure: Insight into identification of biomarkers

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174924 - 174924

Published: July 22, 2024

Language: Английский

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Ferroptosis induced by environmental pollutants and its health implications

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.

Language: Английский

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Probiotics ameliorate benzene-induced systemic inflammation and hematopoietic toxicity by inhibiting Bacteroidaceae-mediated ferroptosis

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 899, P. 165678 - 165678

Published: July 19, 2023

Language: Английский

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What is the impact of ferroptosis on diabetic cardiomyopathy: a systematic review

Heart Failure Reviews, Journal Year: 2023, Volume and Issue: 29(1), P. 1 - 11

Published: Aug. 9, 2023

Language: Английский

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