Lipid mediators in neutrophil biology: inflammation, resolution and beyond DOI

Anita Ghodsi,

Andrés Hidalgo, Stephania Libreros

et al.

Current Opinion in Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Purpose of review Acute inflammation is the body's first defense in response to pathogens or injury. Failure efficiently resolve inflammatory insult can severely affect tissue homeostasis, leading chronic inflammation. Neutrophils play a pivotal role eradicating infectious pathogens, orchestrating initiation and resolution acute inflammation, maintaining physiological functions. The highly orchestrated biochemical process, partially modulated by novel class endogenous lipid mediators known as specialized pro-resolving (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR). Recent findings This focuses on recent advances understanding multifaceted functions SPMs, detailing roles expediting neutrophil apoptosis, promoting clearance macrophages, regulating excessive infiltration at sites, bone marrow deployment, also enhances phagocytosis repair mechanisms under both pathological conditions. We focus functions, differentiation, highlight open questions about SPMs’ heterogeneity. Summary mitigating hyperactivity within milieus, notably conditions such sepsis, cardiovascular disease, ischemic events, cancer. significant function highlights promising therapeutic agents management disorders.

Language: Английский

Regulation of CD8+ T cells by lipid metabolism in cancer progression DOI Creative Commons
Yong Tang, Ziqing Chen, Qianying Zuo

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(11), P. 1215 - 1230

Published: Oct. 14, 2024

Dysregulation of lipid metabolism is a key characteristic the tumor microenvironment, where cells utilize lipids for proliferation, survival, metastasis, and evasion immune surveillance. Lipid has become critical regulator CD8+ T-cell-mediated antitumor immunity, with excess in microenvironment impeding T-cell activities. Considering limited efficacy immunotherapy many solid tumors, targeting to enhance effector functions could significantly improve outcomes. In this review, we examine recent findings on how metabolic processes, including uptake, synthesis, oxidation, regulate T within tumors. We also assessed impact different particular focus affects mitochondrial function tumor-infiltrating cells. Furthermore, as cancer systemic disease, examined factors linking function. Finally, summarize current therapeutic approaches that target increase immunity immunotherapy. Understanding molecular functional interplay between offers promising opportunities treatment.

Language: Английский

Citations

7
The roles of arginases and arginine in immunity DOI
Stefania Canè, Roger Geiger, Vincenzo Bronte

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Language: Английский

Citations

7
Circadian rhythms and breast cancer: unraveling the biological clock’s role in tumor microenvironment and ageing DOI Creative Commons

Yalan Yan,

Lanqian Su,

Shanshan Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved pathogenesis breast cancer. In this paper, we reviewed molecular mechanisms by which dysregulation circadian genes impacts development BC, focusing on critical clock genes, brain muscle ARNT-like protein 1 (BMAL1) locomotor output cycles kaput (CLOCK). We discussed how rhythm disruption (CRD) changes tumor microenvironment (TME), immune responses, inflammation, angiogenesis. The CRD compromises surveillance features activities effectors, including CD8+ T cells tumor-associated macrophages, that are important an effective anti-tumor response. Meanwhile, review, discuss bidirectional interactions: age rhythms, aging further increases risk through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, ability to repair damaged DNA, weakened immunity. These complex interplays open new avenues toward targeted therapies combination drugs with chronotherapy potentiate response while reducing progression for better outcomes. This review tries cover broad area emerging knowledge tumor-immune nexus affected

Language: Английский

Citations

6
Chronic stress influences the macrophage M1-M2 polarization balance through β-adrenergic signaling in hepatoma mice DOI
Juanjuan Yang, Wei Wei,

Shuqun Zhang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112568 - 112568

Published: June 26, 2024

Language: Английский

Citations

5
Nervous system in colorectal cancer DOI
Chunjie Xu, Chunhui Jiang, Yuan Tian

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217431 - 217431

Published: Dec. 1, 2024

Language: Английский

Citations

4
Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity” DOI Creative Commons
Ariana Sattler, Tetiana Korzun, Kasmira Gupta

et al.

Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 20, 2025

Nerve signaling within the tumor microenvironment (TME) plays a critical role in initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior activation upon injury cancer onset, this review specifically focuses on how sympathetic nerves rewire TME. Within tumors, closely interact with various TME components, combined often shifts tumor-intrinsic physiology toward tumor-supportive phenotypes. In turn, such as myeloid cells, lymphoid extracellular matrix (ECM), endothelial associated fibroblasts (CAFs), Schwann secrete neurotrophic axon guidance factors that influence both outgrowth cell behavior, further exacerbating progression metastasis. Here, we current evidence multidirectional impacts immune non-immune nature these communication processes, exploring interactions may inform future therapeutics impair

Language: Английский

Citations

0
The success of the tumor immunotherapy: neutrophils from bench to beside DOI Creative Commons
Meng Zhu, Ru Jia, Xiaojie Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

The present immune therapy was focused on the checkpoint blockade or Chimeric Antigen Receptor T-Cell Immunotherapy (CART) transfer, but how to activate innate system antitumor still lags out. Neutrophils are most abundant circulating leukocytes in human, and heterogeneous neutrophils have been increasingly recognized as important players tumor progression. They play double “edge-sward” by either supporting suppressing growth, including driving angiogenesis, extracellular matrix remodeling promote participating adaptive immunity, killing cells directly inhibit growth. complex role of various tumors depends microenvironment (TME) they located, emerging evidence has suggested that may determine success immunotherapy context blockade, training, drug-loaded microvesicles therapy, which makes them become an exciting target for immunotherapy, with challenges. Here, we summarize latest insights immunity discuss advances neutrophil-targeted strategies.

Language: Английский

Citations

0
α5-nAChR/NETO2 contributed to chronic stress-promoted lung adenocarcinoma progression DOI Creative Commons

Jingting Wang,

Jiaying Cai,

Z. Wang

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 25, 2025

α5-nicotinic acetylcholine receptor (α5‐nAChR) participates in chronic stress-promoted lung adenocarcinoma (LUAD) progression. Neuropilin and tolloid-like 2 (NETO2) contributes to fear expression extinction, which is related tumorigenesis. CHRNA5 (encoding α5‐nAChR) gene profiling revealed a reduction NETO2 following knockdown. Nevertheless, the connection between α5-nAChR LUAD progression induced by stress remains unclear. RNA-Seq bioinformatics database were used for analyzing as well correlation of α5-nAChR, together with LUAD. detected using immunohistochemistry tissue microarrays, restraint (CRS) unpredictable (CUMS) mice tissues. In A549 H1299 cells, NETO2, p-CAMKII, p-STAT3 vimentin acetylcholine/nicotine was examined western blot. The interaction cells Co-immunoprecipitation assay modeled molecular docking. EdU colony formation conducted evaluate cell proliferation, while wound healing transwell assessed migration invasion cells. expression, low survival rate, staging smoking status dataset microarrays. validated nude xenograft correlated CRS CUMS vitro, mediated via α5-nAChR. interacted CAMKII α5-nAChR/NETO2 signaling contributed invasion. above results uncover new pathway: axis

Language: Английский

Citations

0
Glycogen drives tumour initiation and progression in lung adenocarcinoma DOI

Harrison A. Clarke,

Tara R. Hawkinson, Cameron J. Shedlock

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

0
Construction of a Nomogram Model for Predicting Pathologic Complete Response in Breast Cancer Neoadjuvant Chemotherapy Based on the Pan-Immune Inflammation Value DOI Creative Commons

Zhuowan Tian,

Yiqing Xi,

Mengting Chen

et al.

Current Oncology, Journal Year: 2025, Volume and Issue: 32(4), P. 194 - 194

Published: March 27, 2025

The pan-immune inflammation value (PIV) has unclear predictive utility for pathologic complete response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). This study aimed to evaluate the PIV's and develop a nomogram integrating PIV individualized pCR prediction. In retrospective multicenter of 507 NAC-treated (training cohort: 357; validation 150), independent predictors were identified through univariate multivariate logistic regression. A was constructed validated using receiver operating characteristic (ROC) curves, calibration decision curve analysis (DCA). Net reclassification improvement (NRI) integrated discrimination (IDI) evaluated performance after incorporating indicator. high (cutoff: 316.533) had significantly lower rates than low (p < 0.001). PIV, estrogen receptor (ER), human epidermal growth factor receptor-2 (Her2), tumor diameter, clinical node stage, regimen showed excellent cohort area under (AUC): 0.861, 95% confidence interval (CI): 0.821-0.901; AUC: 0.815, CI: 0.748-0.882). curves demonstrate prediction accuracy (Hosmer-Lemeshow test: p > 0.05), while DCA, NRI (0.341, 0.181-0.500), IDI (0.017, 0.004-0.029) confirm utility. is an predictor pCR, PIV-based provides reliable tool optimizing NAC cancer.

Language: Английский

Citations

0