Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis DOI Creative Commons
Noam Savion‐Gaiger,

Dorin Bar‐Ziv,

Harriet M. Kluger

et al.

Molecular Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

The brain is a common site of metastatic dissemination in advanced melanoma. Due to limited access samples from human metastases, our understanding the tumor microenvironment lags behind that other sites, and murine studies are therefore highly informative. Rodriguez‐Baena et al. conducted elegant myeloid cells within melanoma demonstrating their plasticity changes before after colonization by cells. immune‐inhibitory microglial may be reversed or mitigated inhibition RelA/NF‐κB.

Language: Английский

Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis DOI
Martina Molgora, Marco Colonna

Cancer Cell, Journal Year: 2025, Volume and Issue: 43(3), P. 328 - 329

Published: March 1, 2025

Language: Английский

Citations

0
Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis DOI Creative Commons
Noam Savion‐Gaiger,

Dorin Bar‐Ziv,

Harriet M. Kluger

et al.

Molecular Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

The brain is a common site of metastatic dissemination in advanced melanoma. Due to limited access samples from human metastases, our understanding the tumor microenvironment lags behind that other sites, and murine studies are therefore highly informative. Rodriguez‐Baena et al. conducted elegant myeloid cells within melanoma demonstrating their plasticity changes before after colonization by cells. immune‐inhibitory microglial may be reversed or mitigated inhibition RelA/NF‐κB.

Language: Английский

Citations

0