Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 767 - 780
Published: Dec. 5, 2024
Language: Английский
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(13), P. 8991 - 9003
Published: March 21, 2024
Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λem = 1105 nm), as first example Ru(II) supramolecular ICD inducer. synergistically potentiates immunomodulatory and reduces adverse through multiple regulated approaches, including NIR-light excitation, increased reactive oxygen species (ROS) generation, selective targeting tumor cells, precision organelle localization, improved penetration/retention capabilities. Specifically, demonstrates excellent depth-activated ROS production (∼1 cm), resistance to diffusion, anti-ROS quenching. Moreover, exhibits promising results cellular uptake generation cancer cells multicellular spheroids. Importantly, induces more efficient an ultralow dose (10 μM) compared conventional agent, oxaliplatin (300 μM). In vivo experiments further confirm Ru1105's potency inducer, eliciting CD8+ T depleting Foxp3+ effects. Our research lays foundation for design secure exceptionally potent metal-based agents immunotherapy.
Language: Английский
Citations
47
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)
Published: May 22, 2024
Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8
Language: Английский
Citations
14
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 22, 2024
Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses promising strategy for therapy. However, excessive may trigger development inflammatory diseases due to immoderate continuous reactions. Nanomaterials nanobiotechnology, renowned their unique advantages diverse structures, have garnered increasing attention owing potential induce such as cancer. A nano-delivery system drug-induced overcome limitations small molecules. Furthermore, nanomedicines directly manipulate pyroptosis. This review summarizes discusses latest advancements nanoparticle-based treatments with among cancer, focusing on functions mechanisms providing valuable insights into selecting nanodrugs clinical application these strategies still faces challenges limited understanding nanobiological interactions. Finally, future perspectives emerging field pyroptotic nanomaterials are presented.
Language: Английский
Citations
7
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(10)
Published: Oct. 8, 2024
The immune system and cancer cells interact intricately during the growth of tumors, dynamic interplay between activation suppression greatly influences outcome. Natural killer (NK), cytotoxic T lymphocytes (CTLs) Dendritic (DC), employ diverse mechanisms, to combat cancer. However, challenges posed by factors such as chronic inflammation immunosuppressive tumor microenvironment (TME) often hinder cells' ability detect eliminate tumors accurately. Immunotherapy offers a promising approach, reprogramming target eliminating while minimizing side effects, enhancing memory, lowering risk metastasis relapse compared traditional treatments like radiation surgery. Nanotechnology presents potential solution enabling safer, more efficient drug delivery through nanoparticles. These nanoengineered drugs can be tailored for controlled release. Improving TME characters holds personalized immunotherapy addressing cell availability issues within sites, particularly when combined with existing therapies. This review discusses TMEs strategies overcome immunosuppression in TME, various cell-based improve antitumor response. It also focuses on constructing responsive nanoplatforms based upon present at higher levels acidic pH, hypoxia facilitated poor oxygen supply, expression certain enzymes, other light, ultrasound magnetic field. Combination therapies include photodynamic therapy, photothermal chemotherapy, gene therapy radiotherapy, revealing high level anticancer activity comparison single immunogenicity, promoting therapeutic efficacy, metastasis. In conclusion, is technique boost system, hindering their recurrence. order prevent cancer, it helps selectively strengthens its long-term memory. Clinical trials are extending application identifying tumor-fighting capabilities. has enormous promise gives hope successful treatment.
Language: Английский
Citations
5
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(51), P. 6476 - 6487
Published: Jan. 1, 2024
This manuscript summarized the recent progress of MOF-based pyroptosis inducers in immunotherapy.
Language: Английский
Citations
4
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 15, 2025
Cancer immunotherapy aims to harness the body's own immune system for effective and long-lasting elimination of malignant neoplastic tissues. Owing advance in understanding cancer pathology immunology, many novel strategies enhancing immunological responses against various cancers have been successfully developed, some translated into excellent clinical outcomes. As one promising strategy next generation immunotherapies, activating multi-cellular network (MCN) within tumor microenvironment (TME) deploy multiple mechanisms action (MOAs) has attracted significant attention. To achieve this effectively safely, delivering or pleiotropic therapeutic cargoes targeted sites cancerous tissues, cells, intracellular organelles is critical, which numerous nanocarriers developed leveraged. In review, we first introduce payloads categorized according their predicted functions physicochemical structures forms. Then, nanocarriers, along with unique characteristics, properties, advantages, limitations, are introduced notable recent applications immunotherapy. Following discussions on targeting strategies, a summary each nanocarrier matching suitable provided comprehensive background information designing regimens.
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 129 - 144
Published: Sept. 23, 2024
Language: Английский
Citations
3
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Activating specific immunity through intelligent delivery of chemotherapeutic drugs shows great potential for effective tumor therapy. However, conventional microenvironment‐responsive nanomedicines are often difficult to achieve both specificity and sensitivity, leading severe adverse effects or limited drug release efficiency. Furthermore, the immunosuppressive microenvironment will also seriously restrict treatment efficacy. In this work, a cascade‐responsive multi‐polyprodrug nanoregulator is developed. Under with high hydrogen peroxide level, nanoregulators can simultaneously (doxorubicin), indoleamine 2,3‐dioxygenase 1 inhibitor (1‐methyl‐tryptophan) cinnamaldehyde in self‐accelerating manner. The combination reactive oxygen species‐induced ferroptosis doxorubicin‐induced apoptosis synergistically enhance immunogenic cell death activate immune response. released1‐methyl‐tryptophan promote cytotoxic T lymphocyte activation reduce escape by inhibiting tryptophan conversion. Meanwhile, it enhances species scavenging cystine/glutamate antiporter expression, achieving positive feedback ferroptosis‐immunotherapy. This work provides self‐accelerated strategy cooperation mode synergistic immunotherapy based on ferroptosis‐apoptosis.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 247, P. 125849 - 125849
Published: July 17, 2023
Language: Английский
Citations
9
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
Ventricular arrhythmias (VAs) triggered by myocardial infarction (MI) are the leading cause of sudden cardiac mortality worldwide. Current therapeutic strategies for managing MI-induced VAs, such as left stellate ganglion resection and ablation, suboptimal, highlighting need to explore safer more effective intervention strategies. Herein, we rationally designed two supramolecular sonosensitizers RuA RuB, engineered through acceptor modification generate moderate reactive oxygen species (ROS) modulate VAs. Both RuB demonstrated high ultrasound (US)-activated ROS production efficiency, with singlet (
Language: Английский
Citations
3