Experiment-based Abraham model solute descriptors for 2‑[4-(dibutylamino)-2-hydroxybenzoyl]benzoic acid DOI

Audrey Chen,

Jocelyn Chen,

Sri Kowtha

et al.

Physics and Chemistry of Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Nov. 15, 2024

Abraham model solute descriptors for 2‑[4-(dibutylamino)-2-hydroxybenzoyl]benzoic acid were determined from the compound's published solubility data in 10 organic solvents of varying polarity and hydrogen-bonding character. The calculated hydrogen-bond donor descriptor value, A = 0.548, suggests that intramolecular bond formation occurs between hydrogen atom on -OH functional group one two lone pairs electrons oxygen ketone group, >C=O, which would result a six-membered hydrogen-bonded ring structure. much larger A-solute be expected if atoms both -COOH groups free to engage intermolecular H-bond with surrounding solvent molecules.

Language: Английский

Catalytic conversion of cellulose to 5-Hydroxymethylfurfural using montmorillonite-supported transition metal catalysts DOI Creative Commons
Siyao Chen,

He Jiajie,

Ying Liu

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 225, P. 120428 - 120428

Published: Jan. 15, 2025

Language: Английский

Citations

1
Enhanced Butyl Levulinate Synthesis from Cellulose under High-Gravity Conditions: Catalyst and Solvent Optimization DOI Creative Commons
Flóra Viktória Csendes,

Shakila PERERA,

Christine Devouge-Boyer

et al.

Renewable Energy, Journal Year: 2025, Volume and Issue: unknown, P. 123298 - 123298

Published: April 1, 2025

Language: Английский

Citations

0
Investigation on Hansen Solubility Parameter of Caffeine Dissolved in Different Pure Solvents DOI Open Access
María de los Ángeles Peña,

Angeliki. Kaproulia,

Daniel Ricardo Delgado

et al.

Journal of Pharmaceutical Research International, Journal Year: 2024, Volume and Issue: 36(6), P. 167 - 181

Published: May 18, 2024

Aims: Solubility is a molecular property decisive in the entire process from drug development and design to final formulation production, main objective of this paper explain effect variance properties intermolecular interaction on dissolution by Hansen Parameter (HSP) KAT-LSER model. Study Design: Place Duration Study: Department Biomedical Sciences, Faculty Pharmacy. Between April 2023-April 2024. Methodology: The solubility was measured pure mono solvents several chemical classes keys formulation, purification, crystal formation drugs. HSP tested determine partial parameters caffeine. logarithm mole fraction experimental ln X2 as dependent variable used. model used show that solute-solvent interactions are principally attributed dipolarity/polarizability hydrogen bonding basicity. Differential scanning calorimetry (DSC) Fourier transform infrared spectroscopy (FT‐IR) were performed for original powder solid phase after equilibration with solvents. Results: Good results obtained three- four-partial solubility. Since dispersion parameter does not greatly vary one another, variation among largely due dipolar parameters, fact consistently found other drugs small weight. DSC FT-IR allow detection possible changes thermal verify anhydrous nature starting material. Conclusion: showed caffeine mostly affected polarity and/or bonding.

Language: Английский

Citations

1
Experiment-based Abraham model solute descriptors for 2‑[4-(dibutylamino)-2-hydroxybenzoyl]benzoic acid DOI

Audrey Chen,

Jocelyn Chen,

Sri Kowtha

et al.

Physics and Chemistry of Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Nov. 15, 2024

Abraham model solute descriptors for 2‑[4-(dibutylamino)-2-hydroxybenzoyl]benzoic acid were determined from the compound's published solubility data in 10 organic solvents of varying polarity and hydrogen-bonding character. The calculated hydrogen-bond donor descriptor value, A = 0.548, suggests that intramolecular bond formation occurs between hydrogen atom on -OH functional group one two lone pairs electrons oxygen ketone group, >C=O, which would result a six-membered hydrogen-bonded ring structure. much larger A-solute be expected if atoms both -COOH groups free to engage intermolecular H-bond with surrounding solvent molecules.

Language: Английский

Citations

0