Hippocampus,
Journal Year:
2023,
Volume and Issue:
33(4), P. 373 - 390
Published: March 9, 2023
Abstract
Adult
hippocampal
neurogenesis
is
important
for
preserving
learning
and
memory‐related
cognitive
functions.
Physical
exercise,
especially
voluntary
running,
one
of
the
strongest
stimuli
to
promote
has
beneficial
effects
on
Voluntary
running
promotes
exit
neural
stem
cells
(NSCs)
from
quiescent
stage,
proliferation
NSCs
progenitors,
survival
newborn
cells,
morphological
development
immature
neuron,
integration
new
neurons
into
circuitry.
However,
detailed
mechanisms
driving
these
changes
remain
unclear.
In
this
review,
we
will
summarize
current
knowledge
with
respect
molecular
underlying
running‐induced
neurogenesis,
highlighting
recent
genome‐wide
gene
expression
analyses.
addition,
discuss
approaches
future
directions
dissecting
complex
cellular
change
in
adult‐born
response
physical
exercise.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(19), P. 6613 - 6613
Published: Oct. 5, 2022
Aging
is
characterized
by
an
imbalance
between
damage
inflicted
reactive
oxygen
species
(ROS)
and
the
antioxidative
defenses
of
organism.
As
a
significant
nutritional
factor,
trace
element
selenium
(Se)
may
remodel
gradual
spontaneous
physiological
changes
caused
oxidative
stress,
potentially
leading
to
disease
prevention
healthy
aging.
Se
involved
in
improving
antioxidant
defense,
immune
functions,
metabolic
homeostasis.
An
inadequate
status
reduce
human
life
expectancy
accelerating
aging
process
or
increasing
vulnerability
various
disorders,
including
immunity
dysfunction,
cancer
risk.
This
review
highlights
available
studies
on
effective
role
mechanisms
shows
potential
clinical
implications
related
its
consumption.
The
main
sources
organic
advantages
nanoformulations
were
also
discussed.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(5), P. 799 - 799
Published: May 8, 2023
Selenium
is
a
trace
mineral
that
essential
for
health.
After
being
obtained
from
food
and
taken
up
by
the
liver,
selenium
performs
various
physiological
functions
in
body
form
of
selenoproteins,
which
are
best
known
their
redox
activity
anti-inflammatory
properties.
stimulates
activation
immune
cells
important
system.
also
maintenance
brain
function.
supplements
can
regulate
lipid
metabolism,
cell
apoptosis,
autophagy,
have
displayed
significant
alleviating
effects
most
cardiovascular
diseases.
However,
effect
increased
intake
on
risk
cancer
remains
unclear.
Elevated
serum
levels
associated
with
an
type
2
diabetes,
this
relationship
complex
nonlinear.
supplementation
seems
beneficial
to
some
extent;
however,
existing
studies
not
fully
explained
influence
Further,
more
intervention
trials
needed
verify
or
harmful
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: Dec. 8, 2022
Nutrition
plays
an
essential
role
in
the
regulation
of
optimal
immunological
response,
by
providing
adequate
nutrients
sufficient
concentrations
to
immune
cells.
There
are
a
large
number
micronutrients,
such
as
minerals,
and
vitamins,
well
some
macronutrients
amino
acids,
cholesterol
fatty
acids
demonstrated
exert
very
important
specific
impact
on
appropriate
activity.
This
review
aims
summarize
at
extent
amount
data
accrued
date
related
modulation
function
certain
micro
emphasize
their
importance
maintaining
human
health.
Thus,
among
many,
relevant
case
point
examples
brought
discussed:
(1)
The
vitamin
A/all-trans-retinoic-acids
(ATRA)
acute
promyelocytic
leukemia,
being
this
utilized
efficient
therapeutic
agent
via
effective
(2)
involvement
C
fight
against
tumor
cells
increase
active
NK
(3)
stimulation
apoptosis,
suppression
cancer
cell
proliferation,
delayed
development
mediated
calcitriol/vitamin
D
means
immunity
(4)
use
selenium
cofactor
reach
more
response
COVID
vaccination
(5).
crucial
regulate
function,
which
is
be
sensitive
variations
macronutrient
concentration.
Other
reviewed
well.
Journal of Neuroinflammation,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: March 19, 2023
Abstract
Alzheimer’s
disease
(AD)
is
a
chronic
neurodegenerative
disease,
with
the
characteristics
of
neurofibrillary
tangle
(NFT)
and
senile
plaque
(SP)
formation.
Although
great
progresses
have
been
made
in
clinical
trials
based
on
relevant
hypotheses,
these
studies
are
also
accompanied
by
emergence
toxic
side
effects,
it
an
urgent
task
to
explore
underlying
mechanisms
for
benefits
prevent
treat
AD.
Herein,
animal
experiments
few
trials,
neuroinflammation
AD
characterized
long-term
activation
pro-inflammatory
microglia
NOD-,
LRR-
pyrin
domain-containing
protein
3
(NLRP3)
inflammasomes.
Damaged
signals
from
periphery
within
brain
continuously
activate
microglia,
thus
resulting
constant
source
inflammatory
responses.
The
response
exacerbates
endoplasmic
reticulum
oxidative
stress
which
triggers
microglia-dependent
immune
responses,
ultimately
leading
occurrence
deterioration
In
this
review,
we
systematically
summarized
sorted
out
that
exercise
ameliorates
directly
indirectly
regulating
central
nervous
system
promoting
hippocampal
neurogenesis
provide
new
direction
exploring
activity
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Aug. 16, 2023
Abstract
The
beneficial
effects
of
physical
activity
on
brain
ageing
are
well
recognised,
with
exerkines,
factors
that
secreted
into
the
circulation
in
response
to
exercise,
emerging
as
likely
mediators
this
response.
However,
source
and
identity
these
exerkines
remain
unclear.
Here
we
provide
evidence
an
anti-geronic
exerkine
is
by
platelets.
We
show
platelets
activated
exercise
required
for
exercise-induced
increase
hippocampal
precursor
cell
proliferation
aged
mice.
also
demonstrate
increasing
systemic
levels
platelet-derived
CXCL4/platelet
factor
4
(PF4)
ameliorates
age-related
regenerative
cognitive
impairments
a
neurogenesis-dependent
manner.
Together
findings
highlight
role
mediating
rejuvenating
during
physiological
ageing.
Neuron,
Journal Year:
2024,
Volume and Issue:
112(7), P. 1165 - 1181.e8
Published: Jan. 31, 2024
Physical
exercise
is
known
to
reduce
anxiety,
but
the
underlying
brain
mechanisms
remain
unclear.
Here,
we
explore
a
hypothalamo-cerebello-amygdalar
circuit
that
may
mediate
motor-dependent
alleviation
of
anxiety.
This
three-neuron
loop,
in
which
cerebellar
dentate
nucleus
takes
center
stage,
bridges
motor
system
with
emotional
system.
Subjecting
animals
constant
rotarod
engages
glutamatergic
neurons
drive
PKCδ+
amygdalar
elicit
an
anxiolytic
effect.
Moreover,
challenging
on
accelerated
rather
than
hypothalamic
provide
superimposed
effect
via
orexinergic
projection
activate
amygdala.
Our
findings
reveal
cerebello-limbic
pathway
contribute
motor-triggered
anxiety
and
be
optimally
exploited
during
physical
exercise.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: April 15, 2024
Abstract
Osteoclast
hyperactivation
stands
as
a
significant
pathological
factor
contributing
to
the
emergence
of
bone
disorders
driven
by
heightened
oxidative
stress
levels.
The
modulation
redox
balance
scavenge
reactive
oxygen
species
emerges
viable
approach
addressing
this
concern.
Selenoproteins,
characterized
selenocysteine
(SeCys
2
)
active
center,
are
crucial
for
selenium‐based
antioxidative
therapy
inflammatory
diseases.
This
study
reveals
that
surface‐active
elemental
selenium
(Se)
nanoparticles,
particularly
lentinan‐Se
(LNT‐Se),
exhibit
enhanced
cellular
accumulation
and
accelerated
metabolism
SeCys
,
primary
Se
form
in
biological
systems.
Consequently,
LNT‐Se
demonstrates
inhibition
osteoclastogenesis.
Furthermore,
vivo
studies
underscore
superior
therapeutic
efficacy
over
potentially
attributable
stability
safety
profile
LNT‐Se.
Specifically,
effectively
modulates
expression
selenoprotein
GPx1,
thereby
exerting
regulatory
control
osteoclastogenesis
inhibition,
prevention
osteolysis.
In
summary,
these
results
suggest
prompt
activation
selenoproteins
nanoparticles
serves
suppress
loss
upregulating
GPx1.
Moreover,
utilization
bioactive
presents
promising
avenue
managing
disorders.
