Journal of Cerebral Blood Flow & Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
Demyelination
is
a
common
feature
of
neuroinflammatory
and
degenerative
diseases
the
central
nervous
system
(CNS),
such
as
multiple
sclerosis
(MS).
It
often
linked
to
disruptions
in
intercellular
communication,
bioenergetics
metabolic
balance
accompanied
by
mitochondrial
dysfunction
cells
oligodendrocytes,
neurons,
astrocytes,
microglia.
Although
current
MS
treatments
focus
on
immunomodulation,
they
fail
stop
or
reverse
demyelination’s
progression.
Recent
advancements
highlight
exchange
promising
therapeutic
target,
with
potential
restore
homeostasis,
enhance
promote
myelin
repair.
With
this
review
we
will
provide
insights
into
CNS
decoupling,
focusing
role
demyelinating
conditions.
We
then
discuss
emerging
cell-free
biotherapies
exploring
transferring
mitochondria
via
biogenic
carriers
like
extracellular
vesicles
(EVs)
synthetic
liposomes,
aimed
at
enhancing
function
support
for
Lastly,
address
key
challenges
clinical
application
these
strategies
future
directions
optimize
biotherapies.
The
field
hold
promise
restoring
repair,
potentially
transforming
landscape
diseases.
Cell,
Journal Year:
2024,
Volume and Issue:
187(11), P. 2601 - 2627
Published: May 1, 2024
Mitochondria
reside
at
the
crossroads
of
catabolic
and
anabolic
metabolism—the
essence
life.
How
their
structure
function
are
dynamically
tuned
in
response
to
tissue-specific
needs
for
energy,
growth
repair,
renewal
is
being
increasingly
understood.
respond
intrinsic
extrinsic
stresses
can
alter
cell
organismal
by
inducing
metabolic
signaling
within
cells
distal
tissues.
Here,
we
review
how
centrality
mitochondrial
functions
manifests
health
a
broad
spectrum
diseases
aging.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Diabetic
foot
ulcer
(DFU)
is
a
common
and
severe
complication
of
diabetes
mellitus,
the
etiology
which
remains
insufficiently
understood,
particularly
regarding
involvement
extracellular
vesicles
(EVs).
In
this
study,
nanoflow
cytometry
to
detect
EVs
in
DFU
skin
tissues
used
found
significant
increase
Translocase
Outer
Mitochondrial
Membrane
20
(TOM20)+
mitochondrial-derived
(MDVs).
The
role
MDVs
yet
be
reported.
Using
single-cell
datasets,
it
discovered
that
may
regulated
by
Sorting
Nexin
9
(SNX9).
vitro
experiments
revealed
secreted
fibroblasts
cultured
high
glucose
medium
exhibited
similar
composition
protein
enrichment
results
those
tissues,
suggesting
their
potential
as
an
ideal
surrogate.
These
promoted
apoptosis
intracellular
oxidative
stress,
disrupted
mitochondrial
structure,
reduced
aerobic
metabolism
target
cells.
vivo
also
showed
MDV
drops
hindered
wound
healing
diabetic
mice;
however,
effect
rescued
SNX9
inhibitors,
restoring
dynamics
balance.
Under
conditions,
significantly
upregulated
stress
levels
induced
dysfunction.
This
study
proposes
targeting
therapeutic
strategy
for
DFU.
FEBS Journal,
Journal Year:
2024,
Volume and Issue:
291(21), P. 4660 - 4669
Published: Feb. 27, 2024
Mitochondria
are
dynamic,
intracellular
organelles
with
a
separate
genome
originating
from
prokaryotes.
They
perform
numerous
functions
essential
for
cellular
metabolism
and
energy
production.
Mitochondrial‐derived
vesicles
(MDVs)
single
or
double
membrane‐enclosed
vesicles,
formed
released
the
mitochondrial
sub‐compartments
into
cytosol,
in
response
to
various
triggers.
MDVs
interact
other
such
as
lysosomes
peroxisomes
may
be
incorporated
excreted
via
extracellular
(EVs).
selectively
incorporate
diverse
protein
lipid
cargoes
involved
quality
control,
immunomodulation,
complementation,
compartmentalization
transport.
This
review
aims
provide
summary
of
current
knowledge
biogenesis,
release,
cargoes,
roles.
Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
262, P. 108710 - 108710
Published: Aug. 22, 2024
In
an
aging
society,
unveiling
new
anti-aging
strategies
to
prevent
and
combat
aging-related
diseases
is
of
utmost
importance.
Mitochondria
are
the
primary
ATP
production
sites
key
regulators
programmed
cell
death.
Consequently,
these
highly
dynamic
organelles
play
a
central
role
in
maintaining
tissue
function,
mitochondrial
dysfunction
pivotal
factor
progressive
age-related
decline
cellular
homeostasis
organ
function.
The
current
review
examines
recent
advances
understanding
interplay
between
organ-specific
aging.
Thereby,
we
dissect
molecular
mechanisms
underlying
impairment
associated
with
deterioration
exploring
DNA,
reactive
oxygen
species
homeostasis,
metabolic
activity,
damage-associated
patterns,
biogenesis,
turnover,
dynamics.
We
also
highlight
emerging
therapeutic
preclinical
clinical
tests
that
supposed
rejuvenate
such
as
antioxidants,
biogenesis
stimulators,
modulators
turnover
Furthermore,
discuss
potential
benefits
challenges
use
interventions,
emphasizing
need
for
approaches
given
unique
characteristics
different
tissues.
conclusion,
this
highlights
addressing
mitigate
aging,
focusing
on
skin,
liver,
lung,
brain,
skeletal
muscle,
well
reproductive,
immune,
cardiovascular
systems.
Based
comprehensive
multifaceted
roles
mitochondria,
innovative
may
be
developed
optimized
biological
promote
healthy
across
diverse
