The BiteBarrier perimeter: A passive spatial device for tick control and bite prevention

Current Research in Parasitology and Vector-Borne Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 100246 - 100246

Published: Jan. 1, 2025

Language: Английский

---

Computational histology reveals that concomitant application of insect repellent with sunscreen impairs UV protection in an ex vivo human skin model

Parasites & Vectors, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 4, 2025

Histological alterations such as nuclear abnormalities are sensitive biomarkers associated with diseases, tissue injury and environmental insults. While visual inspection human interpretation of histology images useful for initial characterization, low-throughput procedures suffer from inherent limitations in terms reliability, objectivity reproducibility. Artificial intelligence digital morphometry offer unprecedented opportunities to quickly accurately assess morphotypes relation damage including skin injury. In this work, we designed NoxiScore, a pipeline providing an integrated, deep learning-based software solution fully automated quantitative analysis nucleus-related features histological sections biopsies. We used evaluate the efficacy safety three dermato-cosmetic products massively sold at time study Montpellier area (South France): sunscreen containing UV filters, mosquito repellent (with synthetic active ingredient IR3535) product combining natural insect plus sunscreen. Hematoxylin eosin or hematoxylin-eosin saffron staining was performed structure before morphometric parameter computation. report identification specific feature based on variation texture information that can be after oxidative stress exposure. Our data show application commercial sun cream provided efficient protection against effects our ex vivo model, whereas single exerted no protective toxic effect. Notably, found concurrent significantly decreased UVB effect Last, histometric biopsies multiple donors indicates sunscreen-insect combo displayed variable levels irradiation. To knowledge, is first potential toxicity real-life using samples, which most closely imitate cutaneous physiology. The NoxiScore wet-plus-dry methodology has provide about pharmaco-toxicological profile topically applied formulations may also diagnostic purposes evaluation exposome pesticide exposure, air pollution water contaminants.

Language: Английский

---

Editorial overview: Vectors and medical and veterinary entomology: an integrative view

Current Opinion in Insect Science, Journal Year: 2024, Volume and Issue: unknown, P. 101283 - 101283

Published: Oct. 1, 2024

Language: Английский

---