Colloids and Interface Science Communications,
Journal Year:
2023,
Volume and Issue:
57, P. 100752 - 100752
Published: Nov. 1, 2023
Various
skin
infections
present
a
substantial
challenge
in
both
patient
care
and
the
medical
community.
A
primary
obstacle
to
effective
wound
healing
is
colonization
of
pathogenic
bacteria,
which
would
produce
hyaluronidase
(HAase).
This
enzyme
degrades
hyaluronic
acid
(HA)
at
sites,
facilitating
bacterial
infection.
Herein,
we
developed
HAase-responsive
hydrogel,
HA-EPL-PEG,
incorporating
antimicrobial
peptide
ε-Poly-l-lysine
(EPL)
Polyethylene
glycol
diacrylate
(PEGDA),
chemically
crosslinked
via
photoinitiator.
Following,
vitro
antibacterial
antifouling
properties
this
hydrogel
were
evaluated,
along
with
its
cytotoxicity
mammalian
cells.
Subsequently,
bacteria
secreted
HAase
responsive
functionality
was
evaluated.
In
vivo
antibacterial,
anti-infectious
effects
further
investigated
rodent
model.
All
these
results
demonstrated
multifunctional
benefits
HA-EPL-PEG
showcasing
nature,
activities.
Importantly,
significantly
expedited
full-thickness
wounds,
denoting
promising
avenue
for
advancing
care.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(6), P. 1006 - 1006
Published: March 18, 2022
Nanotechnology
is
a
powerful
tool
for
engineering
functional
materials
that
has
the
potential
to
transform
textiles
into
high-performance,
value-added
products.
In
recent
years,
there
been
considerable
interest
in
development
of
using
metal
nanoparticles
(MNPs).
The
incorporation
MNPs
allows
obtention
multifunctional
properties,
such
as
ultraviolet
(UV)
protection,
self-cleaning,
and
electrical
conductivity,
well
antimicrobial,
antistatic,
antiwrinkle,
flame
retardant
without
compromising
inherent
characteristics
textile.
Environmental
sustainability
also
one
main
motivations
innovation
textile
industry.
Thus,
synthesis
ecofriendly
sources,
polysaccharides,
high
importance.
functions
polysaccharides
these
processes
are
reduction
stabilization
MNPs,
adhesion
onto
fabrics.
This
review
covers
major
research
attempts
obtain
with
different
properties
MNPs.
reported
include
chitosan,
alginate,
starch,
cyclodextrins,
cellulose,
silver,
zinc,
copper,
titanium
being
most
explored
applications
functionalized
reported,
they
healthcare
(wound
dressing,
drug
release),
protection
(antimicrobial
activity,
UV
retardant),
environmental
remediation
(catalysts).
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1364 - 1364
Published: April 28, 2023
Polysaccharides
are
naturally
occurring
complex
molecules
with
exceptional
physicochemical
properties
and
bioactivities.
They
originate
from
plant,
animal,
microbial-based
resources
processes
can
be
chemically
modified.
The
biocompatibility
biodegradability
of
polysaccharides
enable
their
increased
use
in
nanoscale
synthesis
engineering
for
drug
encapsulation
release.
This
review
focuses
on
sustained
release
studies
the
fields
nanotechnology
biomedical
sciences.
Particular
emphasis
is
placed
kinetics
relevant
mathematical
models.
An
effective
model
used
to
envision
behavior
specific
polysaccharide
matrices
reduce
impending
experimental
trial
error,
saving
time
resources.
A
robust
also
assist
translating
vitro
vivo
experiments.
main
aim
this
demonstrate
that
any
study
establishes
should
accompanied
by
a
detailed
analysis
modeling
since
not
only
involves
diffusion
degradation
but
surface
erosion,
complicated
swelling
dynamics,
crosslinking,
drug-polymer
interactions.
As
such,
first
part,
we
discuss
classification
role
various
applications
later
elaborate
pharmaceutical
ionic
gelling,
stabilization,
cross-linking,
grafting,
drugs.
We
document
several
models
applied
hydrogels,
nanofibers,
nanoparticles
conclude
that,
at
times,
more
than
one
accurately
describe
profiles,
indicating
existence
mechanisms
running
parallel.
Finally,
future
opportunities
advanced
nanoengineered
theranostic
aptitudes
clinical
applications.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 503 - 503
Published: Feb. 2, 2023
Chitosan
is
a
positively
charged
polysaccharide
obtained
through
chitin
deacetylation.
It
belongs
to
group
of
biodegradable,
bioavailable,
and
non-toxic
materials
natural
origin;
thus,
it
promising
matrix
for
creating
delivery
systems
different
active
agents.
Recently,
much
attention
has
been
paid
nanodelivery
as
carriers
enable
better
bioavailability,
thus
higher
efficiency
the
loaded
drug.
The
present
review
focused
on
progress
in
chitosan-based
nanoparticles
targeted
antitumor
drugs.
paper
discusses
literature
reports
from
last
three
years
which
chitosan
were
applied
substances
used
therapy
potential
new
drugs
with
anticancer
properties.
Special
was
treatments
increase
therapeutic
effectiveness
minimize
side
effects
specific
substance.
Chemistry - A European Journal,
Journal Year:
2022,
Volume and Issue:
28(67)
Published: Sept. 8, 2022
Polymer
alternatives
sourced
from
nature
have
attracted
increasing
attention
for
applications
in
medicine,
cosmetics,
agriculture,
food,
water
purification,
and
more.
Among
them,
chitosan
is
the
most
versatile
due
to
its
full
biodegradability,
exceptional
biocompatibility,
multipurpose
bioactivity,
low
toxicity.
Although
remarkable
progress
has
been
made
synthetic
modification
by
using
C3/C6
secondary/primary
hydroxy
(-OH)
C2
amino
(-NH2
)
active
sites,
solubility
under
physiological
conditions
remains
limited
hampered
larger-scale
adoption.
This
review
summarizes
different
methods
that
increase
chitosan's
hydrophilicity
covalent
modifications,
namely
acid
addition,
quaternary
ammonium
formation,
phosphorylation,
carboxymethylation.
We
also
several
each
type
of
substitution
fields
such
as
provide
an
outlook
perspective
future
modifications
implementations.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(19), P. 4189 - 4189
Published: Oct. 6, 2022
Polysaccharides
constitute
one
of
the
most
important
families
biopolymers.
Natural
polysaccharide-based
drug
delivery
systems
are
constant
interest
to
scientific
community
due
their
unique
properties:
biocompatibility,
non-toxicity,
biodegradability,
and
high
availability.
These
promising
biomaterials
protect
sensitive
active
agents
provide
controlled
release
in
targeted
sites.
The
application
natural
polysaccharides
as
is
also
intensively
developed
by
Polish
scientists.
present
review
focuses
on
case
studies
from
last
few
years
authored
or
co-authored
research
centers
Poland.
A
particular
emphasis
was
placed
diversity
formulations
terms
substance
carried,
route,
composition
material,
its
preparation
method.
