Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4710 - 4710

Published: April 26, 2024

Sepsis-induced cardiomyopathy (SICM) is one of the leading indicators for poor prognosis associated with sepsis. Despite its reversibility, varies widely among patients. Mitochondria play a key role in cellular energy production by generating adenosine triphosphate (ATP), which vital myocardial metabolism. Over recent years, mounting evidence suggests that severe sepsis not only triggers mitochondrial structural abnormalities such as apoptosis, incomplete autophagy, and mitophagy cardiomyocytes but also compromises their function, to ATP depletion. This metabolic disruption recognized significant contributor SICM, yet effective treatment options remain elusive. Sepsis cannot be effectively treated inotropic drugs failing myocardium due excessive inflammatory factors blunt β-adrenergic receptors. review will share knowledge on cell death molecular mechanisms, focusing mitochondria an important regulator discuss potential developing therapies sepsis-induced injury.

Language: Английский

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FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(7), P. 167307 - 167307

Published: June 17, 2024

Language: Английский

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Vaccarin alleviates septic cardiomyopathy by potentiating NLRP3 palmitoylation and inactivation

Phytomedicine, Journal Year: 2024, Volume and Issue: 131, P. 155771 - 155771

Published: May 31, 2024

Language: Английский

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Ablation of Mitophagy Receptor FUNDC1 Accentuates Septic Cardiomyopathy through ACSL4-Dependent Regulation of Ferroptosis and Mitochondrial Integrity

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 75 - 86

Published: Sept. 24, 2024

Language: Английский

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Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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ZC3H13 may participate in the ferroptosis process of sepsis-induced cardiomyopathy by regulating the expression of Pnn and Rbm25

Gene, Journal Year: 2024, Volume and Issue: unknown, P. 148944 - 148944

Published: Sept. 1, 2024

Language: Английский

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KLF2 Inhibits Ferroptosis and Improves Mitochondrial Dysfunction in Chondrocyte Through SIRT1/GPX4 Signaling to Improve Osteoarthritis

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(7)

Published: Nov. 1, 2024

Osteoarthritis (OA), a disease of articular joints, is the leading cause disability in elderly. Repressing ferroptosis and improving mitochondrial function can delay progression OA. Kruppel-like factor 2 (KLF2) exerts protective effect on However, whether KLF2 affects during OA remains unknown. The vivo vitro models were constructed this work. structural damage knee joint mice was evaluated through Micro-CT scanning. H&E, SOFG, TB, TUNEL staining applied for pathological examination cartilage tissues. ELISA employed to examine contents inflammatory factors. Additionally, iron deposition tissues measured by Prussian blue staining, levels proteins related assessed immunoblotting. Besides, morphology estimated using transmission electron microscope JC-1 staining. In interleukin (IL)-1β-treated C28/I2 cells, factors, intracellular ROS, lipid Fe

Language: Английский

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COX-2 optimizes cardiac mitochondrial biogenesis and exerts a cardioprotective effect during sepsis

Cytokine, Journal Year: 2024, Volume and Issue: 182, P. 156733 - 156733

Published: Aug. 10, 2024

Language: Английский

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